A minimal domain responsible for Munc13 activity (original) (raw)

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Acknowledgements

We thank T. Südhof for fruitful discussions, H. Deng and R. Nehring for technical support and N. Brose (Max Planck Institute for Experimental Medicine, Gottingen, Germany) for providing the Munc13-1 and Munc13-2 double-knockout mice and the pSFV1-Munc13-1WT-EGFP vector. This work was supported by a grant from the Muscular Dystrophy Association and by US National Institutes of Health grants NS37200 to J.R. and NS51262 to C.R.

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Author notes

  1. Jayeeta Basu and Nan Shen: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, 77030, Texas, USA
    Jayeeta Basu & Christian Rosenmund
  2. Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, 77030, Texas, USA
    Jayeeta Basu & Christian Rosenmund
  3. Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390, Texas, USA
    Nan Shen, Irina Dulubova, Jun Lu, Rong Guan, Oleg Guryev, Nick V Grishin & Josep Rizo
  4. Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390, Texas, USA
    Nan Shen, Irina Dulubova, Jun Lu, Rong Guan, Oleg Guryev & Josep Rizo
  5. Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390, Texas, USA
    Nick V Grishin

Authors

  1. Jayeeta Basu
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  2. Nan Shen
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  3. Irina Dulubova
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  4. Jun Lu
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  5. Rong Guan
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  6. Oleg Guryev
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  7. Nick V Grishin
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  8. Christian Rosenmund
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  9. Josep Rizo
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Corresponding author

Correspondence toJosep Rizo.

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The authors declare no competing financial interests.

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Basu, J., Shen, N., Dulubova, I. et al. A minimal domain responsible for Munc13 activity.Nat Struct Mol Biol 12, 1017–1018 (2005). https://doi.org/10.1038/nsmb1001

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