Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency (original) (raw)
Eckardt, K.U. & Kurtz, A. Regulation of erythropoietin production. Eur. J. Clin. Invest.35 Suppl. 3, 13–19 (2005). ArticleCAS Google Scholar
Leung, P.S., Srai, S.K., Mascarenhas, M., Churchill, L.J. & Debnam, E.S. Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression. Gut54, 1391–1395 (2005). ArticleCAS Google Scholar
Wang, G.L., Jiang, B.H., Rue, E.A. & Semenza, G.L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA92, 5510–5514 (1995). ArticleCAS Google Scholar
Ema, M. et al. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. USA94, 4273–4278 (1997). ArticleCAS Google Scholar
Flamme, I. et al. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels. Mech. Dev.63, 51–60 (1997). ArticleCAS Google Scholar
Hogenesch, J.B. et al. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. Biol. Chem.272, 8581–8593 (1997). ArticleCAS Google Scholar
Tian, H., McKnight, S.L. & Russell, D.W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev.11, 72–82 (1997). ArticleCAS Google Scholar
Wenger, R.H. & Gassmann, M. Oxygen(es) and the hypoxia-inducible factor-1. Biol. Chem.378, 609–616 (1997). CASPubMed Google Scholar
Schofield, C.J. & Ratcliffe, P.J. Oxygen sensing by HIF hydroxylases. Nat. Rev. Mol. Cell Biol.5, 343–354 (2004). ArticleCAS Google Scholar
Kallio, P.J., Wilson, W.J., O'Brien, S., Makino, Y. & Poellinger, L. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J. Biol. Chem.274, 6519–6525 (1999). ArticleCAS Google Scholar
Lando, D., Peet, D.J., Whelan, D.A., Gorman, J.J. & Whitelaw, M.L. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science295, 858–861 (2002). ArticleCAS Google Scholar
Semenza, G.L. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol. Med.7, 345–350 (2001). ArticleCAS Google Scholar
Hu, C.J., Wang, L.Y., Chodosh, L.A., Keith, B. & Simon, M.C. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell. Biol.23, 9361–9374 (2003). ArticleCAS Google Scholar
Warnecke, C. et al. Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J.18, 1462–1464 (2004). ArticleCAS Google Scholar
Smith, K. et al. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL−/− renal cancer. Cancer Res.65, 5221–5230 (2005). ArticleCAS Google Scholar
Hentze, M.W., Muckenthaler, M.U. & Andrews, N.C. Balancing acts: molecular control of mammalian iron metabolism. Cell117, 285–297 (2004). ArticleCAS Google Scholar
Wallander, M.L., Leibold, E.A. & Eisenstein, R.S. Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochim. Biophys. Acta1763, 668–689 (2006). ArticleCAS Google Scholar
Sanchez, M. et al. Iron regulation and the cell cycle: identification of an iron-responsive element in the 3′-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. J. Biol. Chem.281, 22865–22874 (2006). ArticleCAS Google Scholar
Muckenthaler, M., Gray, N.K. & Hentze, M.W. IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F. Mol. Cell2, 383–388 (1998). ArticleCAS Google Scholar
Gray, N.K., Pantopoulos, K., Dandekar, T., Ackrell, B.A. & Hentze, M.W. Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Proc. Natl. Acad. Sci. USA93, 4925–4930 (1996). ArticleCAS Google Scholar
Liu, X.B., Hill, P. & Haile, D.J. Role of the ferroportin iron-responsive element in iron and nitric oxide dependent gene regulation. Blood Cells Mol. Dis.29, 315–326 (2002). ArticleCAS Google Scholar
Binder, R. et al. Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening. EMBO J.13, 1969–1980 (1994). ArticleCAS Google Scholar
Smith, S.R., Ghosh, M.C., Ollivierre-Wilson, H., Hang Tong, W. & Rouault, T.A. Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development. Blood Cells Mol. Dis.36, 283–287 (2006). ArticleCAS Google Scholar
Galy, B., Ferring, D. & Hentze, M.W. Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes. Genesis43, 181–188 (2005). ArticleCAS Google Scholar
Hentze, M.W. et al. A model for the structure and functions of iron-responsive elements. Gene72, 201–208 (1988). ArticleCAS Google Scholar
Gunshin, H. et al. Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett.509, 309–316 (2001). ArticleCAS Google Scholar
Goossen, B. & Hentze, M.W. Position is the critical determinant for function of iron-responsive elements as translational regulators. Mol. Cell. Biol.12, 1959–1966 (1992). ArticleCAS Google Scholar
Paraskeva, E., Gray, N.K., Schlager, B., Wehr, K. & Hentze, M.W. Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements. Mol. Cell. Biol.19, 807–816 (1999). ArticleCAS Google Scholar
Hentze, M.W. et al. Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. Science238, 1570–1573 (1987). ArticleCAS Google Scholar
Maxwell, P.H. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature399, 271–275 (1999). ArticleCAS Google Scholar
Bernardi, R. et al. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature442, 779–785 (2006). ArticleCAS Google Scholar
Lang, K.J., Kappel, A. & Goodall, G.J. Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol. Biol. Cell13, 1792–1801 (2002). ArticleCAS Google Scholar
Kallio, P.J. et al. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J.17, 6573–6586 (1998). ArticleCAS Google Scholar
Semenza, G.L. et al. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem.271, 32529–32537 (1996). ArticleCAS Google Scholar
Wiesener, M.S. et al. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J.17, 271–273 (2003). ArticleCAS Google Scholar
Ryan, H.E., Lo, J. & Johnson, R.S. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J.17, 3005–3015 (1998). ArticleCAS Google Scholar
Peng, J., Zhang, L., Drysdale, L. & Fong, G.H. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc. Natl. Acad. Sci. USA97, 8386–8391 (2000). ArticleCAS Google Scholar
Tian, H., Hammer, R.E., Matsumoto, A.M., Russell, D.W. & McKnight, S.L. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev.12, 3320–3324 (1998). ArticleCAS Google Scholar
Compernolle, V. et al. Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat. Med.8, 702–710 (2002). ArticleCAS Google Scholar
Scortegagna, M., Morris, M.A., Oktay, Y., Bennett, M. & Garcia, J.A. The HIF family member EPAS1/HIF-2alpha is required for normal hematopoiesis in mice. Blood102, 1634–1640 (2003). ArticleCAS Google Scholar
Scortegagna, M. et al. HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood105, 3133–3140 (2005). ArticleCAS Google Scholar
Morita, M. et al. HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J.22, 1134–1146 (2003). ArticleCAS Google Scholar
Ding, K., Scortegagna, M., Seaman, R., Birch, D.G. & Garcia, J.A. Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha. Invest. Ophthalmol. Vis. Sci.46, 1010–1016 (2005). Article Google Scholar
Rosenberger, C. et al. Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J. Am. Soc. Nephrol.13, 1721–1732 (2002). ArticleCAS Google Scholar
Gray, N.K. et al. Recombinant iron-regulatory factor functions as an iron-responsive-element-binding protein, a translational repressor and an aconitase. A functional assay for translational repression and direct demonstration of the iron switch. Eur. J. Biochem.218, 657–667 (1993). ArticleCAS Google Scholar
Korner, C.G. et al. The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes. EMBO J.17, 5427–5437 (1998). ArticleCAS Google Scholar
Benes, V. & Muckenthaler, M. Standardization of protocols in cDNA microarray analysis. Trends Biochem. Sci.28, 244–249 (2003). ArticleCAS Google Scholar
Hanson, E.S., Foot, L.M. & Leibold, E.A. Hypoxia post-translationally activates iron-regulatory protein 2. J. Biol. Chem.274, 5047–5052 (1999). ArticleCAS Google Scholar
Toth, I., Yuan, L., Rogers, J.T., Boyce, H. & Bridges, K.R. Hypoxia alters iron-regulatory protein-1 binding capacity and modulates cellular iron homeostasis in human hepatoma and erythroleukemia cells. J. Biol. Chem.274, 4467–4473 (1999). ArticleCAS Google Scholar
Christova, T. & Templeton, D.M. Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins. Mol. Cell. Biochem., published online 3 January 2007.