Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A (original) (raw)

• Altomare DA, Testa JR . (2005). Perturbations of the AKT signaling pathway in human cancer. Oncogene 24: 7455–7464.
  Article CAS PubMed Google Scholar
• Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B . (2007). Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proc Natl Acad Sci USA 104: 19011–19016.
  Article CAS PubMed PubMed Central Google Scholar
• Arthur JS, Elce JS, Hegadorn C, Williams K, Greer PA . (2000). Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Mol Cell Biol 20: 4474–4481.
  Article CAS PubMed PubMed Central Google Scholar
• Barreyro FJ, Kobayashi S, Bronk SF, Werneburg NW, Malhi H, Gores GJ . (2007). Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. J Biol Chem 282: 27141–27154.
  Article CAS PubMed Google Scholar
• Biggs III WH, Meisenhelder J, Hunter T, Cavenee WK, Arden KC . (1999). Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 96: 7421–7426.
  Article CAS PubMed PubMed Central Google Scholar
• Brummelkamp TR, Bernards R, Agami R . (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550–553.
  Article CAS PubMed Google Scholar
• Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS et al. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857–868.
  Article CAS PubMed Google Scholar
• Carragher NO, Fonseca BD, Frame MC . (2004). Calpain activity is generally elevated during transformation but has oncogene-specific biological functions. Neoplasia 6: 53–73.
  Article CAS PubMed PubMed Central Google Scholar
• Darnell GA, Schroder WA, Antalis TM, Lambley E, Major L, Gardner J et al. (2007). Human papillomavirus E7 requires the protease calpain to degrade the retinoblastoma protein. J Biol Chem 282: 37492–37500.
  Article CAS PubMed Google Scholar
• Demarchi F, Bertoli C, Copetti T, Eskelinen EL, Schneider C . (2007). Calpain as a novel regulator of autophagosome formation. Autophagy 3: 235–237.
  Article CAS PubMed Google Scholar
• Demarchi F, Bertoli C, Copetti T, Tanida I, Brancolini C, Eskelinen EL et al. (2006). Calpain is required for macroautophagy in mammalian cells. J Cell Biol 175: 595–605.
  Article CAS PubMed PubMed Central Google Scholar
• Demarchi F, Bertoli C, Greer PA, Schneider C . (2005). Ceramide triggers an NF-kappaB-dependent survival pathway through calpain. Cell Death Differ 12: 512–522.
  Article CAS PubMed Google Scholar
• Dijkers PF, Birkenkamp KU, Lam EW, Thomas NS, Lammers JW, Koenderman L et al. (2002). FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol 156: 531–542.
  Article CAS PubMed PubMed Central Google Scholar
• Dourdin N, Bhatt AK, Dutt P, Greer PA, Arthur JS, Elce JS et al. (2001). Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts. J Biol Chem 276: 48382–48388.
  Article CAS PubMed Google Scholar
• Essafi A, Fernandez de Mattos S, Hassen YA, Soeiro I, Mufti GJ, Thomas NS et al. (2005). Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. Oncogene 24: 2317–2329.
  Article CAS PubMed Google Scholar
• Gao T, Furnari F, Newton AC . (2005). PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18: 13–24.
  Article CAS PubMed Google Scholar
• Goll DE, Thompson VF, Li H, Wei W, Cong J . (2003). The calpain system. Physiol Rev 83: 731–801.
  Article CAS PubMed Google Scholar
• Greer EL, Brunet A . (2005). FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24: 7410–7425.
  Article CAS PubMed Google Scholar
• Guan N, Korukonda R, Hurh E, Schmittgen TD, Donkor IO, Dalton JT . (2006). Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines. Int J Oncol 29: 655–663.
  CAS PubMed Google Scholar
• Harriman JF, Liu XL, Aleo MD, Machaca K, Schnellmann RG . (2002). Endoplasmic reticulum Ca(2+) signaling and calpains mediate renal cell death. Cell Death Differ 9: 734–741.
  Article CAS PubMed Google Scholar
• Janssens V, Goris J . (2001). Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 353: 417–439.
  Article CAS PubMed PubMed Central Google Scholar
• Kops GJ, Burgering BM . (1999). Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling. J Mol Med 77: 656–665.
  Article CAS PubMed Google Scholar
• Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI et al. (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943–1947.
  Article CAS PubMed Google Scholar
• Libertini SJ, Robinson BS, Dhillon NK, Glick D, George M, Dandekar S et al. (2005). Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype. Cancer Res 65: 10700–10708.
  Article CAS PubMed Google Scholar
• Manning BD, Cantley LC . (2007). AKT/PKB signaling: navigating downstream. Cell 129: 1261–1274.
  Article CAS PubMed PubMed Central Google Scholar
• Millward TA, Zolnierowicz S, Hemmings BA . (1999). Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci 24: 186–191.
  Article CAS PubMed Google Scholar
• Mumby M . (2007). PP2A: unveiling a reluctant tumor suppressor. Cell 130: 21–24.
  Article CAS PubMed Google Scholar
• Nakamura N, Ramaswamy S, Vazquez F, Signoretti S, Loda M, Sellers WR . (2000). Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol 20: 8969–8982.
  Article CAS PubMed PubMed Central Google Scholar
• Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z et al. (2007). FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128: 309–323.
  Article CAS PubMed PubMed Central Google Scholar
• Reagan-Shaw S, Ahmad N . (2006). RNA interference-mediated depletion of phosphoinositide 3-kinase activates forkhead box class O transcription factors and induces cell cycle arrest and apoptosis in breast carcinoma cells. Cancer Res 66: 1062–1069.
  Article CAS PubMed Google Scholar
• Resjo S, Goransson O, Harndahl L, Zolnierowicz S, Manganiello V, Degerman E . (2002). Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Cell Signal 14: 231–238.
  Article CAS PubMed Google Scholar
• Rocher G, Letourneux C, Lenormand P, Porteu F . (2007). Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity. J Biol Chem 282: 5468–5477.
  Article CAS PubMed Google Scholar
• Sablina AA, Chen W, Arroyo JD, Corral L, Hector M, Bulmer SE et al. (2007). The tumor suppressor PP2A Abeta regulates the RalA GTPase. Cell 129: 969–982.
  Article CAS PubMed PubMed Central Google Scholar
• Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A et al. (2004). Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117: 399–412.
  Article CAS PubMed PubMed Central Google Scholar
• Sato S, Fujita N, Tsuruo T . (2000). Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci USA 97: 10832–10837.
  Article CAS PubMed PubMed Central Google Scholar
• Seeling JM, Miller JR, Gil R, Moon RT, White R, Virshup DM . (1999). Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science 283: 2089–2091.
  Article CAS PubMed Google Scholar
• Sunters A, Fernandez de Mattos S, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA et al. (2003). FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem 278: 49795–49805.
  Article CAS PubMed Google Scholar
• Tan Y, Wu C, De Veyra T, Greer PA . (2006). Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli. J Biol Chem 281: 17689–17698.
  Article CAS PubMed Google Scholar
• Tang ED, Nunez G, Barr FG, Guan KL . (1999). Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem 274: 16741–16746.
  Article CAS PubMed Google Scholar
• Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP . (2006). Identification of a tumour suppressor network opposing nuclear Akt function. Nature 441: 523–527.
  Article CAS PubMed PubMed Central Google Scholar
• Trotman LC, Niki M, Dotan ZA, Koutcher JA, Di Cristofano A, Xiao A et al. (2003). Pten dose dictates cancer progression in the prostate. PLoS Biol 1: E59.
  Article PubMed PubMed Central Google Scholar
• van der Horst A, Burgering BM . (2007). Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 8: 440–450.
  Article CAS PubMed Google Scholar
• Van Kanegan MJ, Adams DG, Wadzinski BE, Strack S . (2005). Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. J Biol Chem 280: 36029–36036.
  Article CAS PubMed Google Scholar
• Xu L, Deng X . (2006). Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of mu- and m-calpains. J Biol Chem 281: 35567–35575.
  Article CAS PubMed Google Scholar
• Yan L, Lavin VA, Moser LR, Cui Q, Kanies C, Yang E . (2008). PP2A regulates the pro-apoptotic activity of FOXO1. J Biol Chem 283: 7411–7420.
  Article CAS PubMed PubMed Central Google Scholar
• Yin KJ, Hsu CY, Hu XY, Chen H, Chen SW, Xu J et al. (2006). Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death. J Neurosci 26: 2290–2299.
  Article CAS PubMed PubMed Central Google Scholar
• You H, Pellegrini M, Tsuchihara K, Yamamoto K, Hacker G, Erlacher M et al. (2006). FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med 203: 1657–1663.
  Article CAS PubMed PubMed Central Google Scholar
• Zatz M, Starling A . (2005). Calpains and disease. N Engl J Med 352: 2413–2423.
  Article CAS PubMed Google Scholar
• Zhang X, Gan L, Pan H, Guo S, He X, Olson ST et al. (2002). Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J Biol Chem 277: 45276–45284.
  Article CAS PubMed Google Scholar