The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival (original) (raw)

• Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H et al. (2004). Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 6: 17–32.
  Article CAS PubMed Google Scholar
• Baserga R . (2005). The insulin-like growth factor-I receptor as a target for cancer therapy. Expert Opin Ther Targets 9: 753–768.
  Article CAS PubMed Google Scholar
• Boyum A . (1964). Separation of white blood cells. Nature 204: 793–794.
  Article CAS PubMed Google Scholar
• Burtrum D, Zhu Z, Lu D, Anderson DM, Prewett M, Pereira DS et al. (2003). A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res 63: 8912–8921.
  CAS PubMed Google Scholar
• Byron SA, Horwitz KB, Richer JK, Lange CA, Zhang X, Yee D . (2006). Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells. Br J Cancer 95: 1220–1228.
  Article CAS PubMed PubMed Central Google Scholar
• Chambers AF, Groom AC, MacDonald IC . (2002). Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2: 563–572.
  Article CAS PubMed Google Scholar
• Cohen BD, Baker DA, Soderstrom C, Tkalcevic G, Rossi AM, Miller PE et al. (2005). Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751 871. Clin Cancer Res 11: 2063–2073.
  Article CAS PubMed Google Scholar
• Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X et al. (2006). Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2. Mol Cell Biol 26: 9302–9314.
  Article CAS PubMed PubMed Central Google Scholar
• Dunn SE, Ehrlich M, Sharp NJ, Reiss K, Solomon G, Hawkins R et al. (1998). A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer. Cancer Res 58: 3353–3361.
  CAS PubMed Google Scholar
• Garcia-Echeverria C, Pearson MA, Marti A, Meyer T, Mestan J, Zimmermann J et al. (2004). in vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell 5: 231–239.
  Article CAS PubMed Google Scholar
• Gibson SL, Ma Z, Shaw LM . (2007). Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis. Cell Cycle 6: 631–637.
  Article CAS PubMed Google Scholar
• Gupta GP, Massague J . (2006). Cancer metastasis: building a framework. Cell 127: 679–695.
  Article CAS PubMed Google Scholar
• Gupta GP, Minn AJ, Kang Y, Siegel PM, Serganova I, Cordon-Cardo C et al. (2005). Identifying site-specific metastasis genes and functions. Cold Spring Harb Symp Quant Biol 70: 149–158.
  Article CAS PubMed Google Scholar
• Haluska P, Carboni JM, Loegering DA, Lee FY, Wittman M, Saulnier MG et al. (2006). in vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417. Cancer Res 66: 362–371.
  Article CAS PubMed Google Scholar
• Haluska P, Shaw HM, Batzel GN, Yin D, Molina JR, Molife LR et al. (2007). Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751 871 in patients with refractory solid tumors. Clin Cancer Res 13: 5834–5840.
  Article CAS PubMed Google Scholar
• Higano CS, Yu EY, Whiting SH, Gordon MS, LoRusso P, Fox F et al. (2007). A phase I, first in human study of weekly IMC-A12, a human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors. J Clin Oncology 25 (No 18S): 3505.
  Google Scholar
• Jackson JG, White MF, Yee D . (1998). Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells. J Biol Chem 273: 9994–10003.
  Article CAS PubMed Google Scholar
• Jackson JG, Zhang X, Yoneda T, Yee D . (2001). Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines. Oncogene 20: 7318–7325.
  Article CAS PubMed Google Scholar
• Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordon-Cardo C et al. (2003). A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3: 537–549.
  Article CAS PubMed Google Scholar
• Karp DD, Paz-Ares LG, Blakely LJ, Kreisman H, Cohen RB, Langer CJ et al. (2007). Efficacy of the anti-insulin like growth factor I receptor (IGF-IR) antibody CP 751 871 in combination with paclitaxel and carboplatin as first-line treatment for advanced non-small cell lung cancer (NSCLC). J Clin Oncology 25 (No 18S): 7506.
  Google Scholar
• Laemmli UK . (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680–685.
  Article CAS PubMed Google Scholar
• Leonessa F, Green D, Licht T, Wright A, Wingatelegette K, Lippman J et al. (1996). MDA435/LCC6 and MDA435/LCC6(MDR1): ascites models of human breast cancer. Br J Cancer 73: 154–161.
  Article CAS PubMed PubMed Central Google Scholar
• Li SL, Liang SJ, Guo N, Wu AM, Fujita-Yamaguchi Y . (2000). Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth. Cancer Immunol Immunother 49: 243–252.
  Article CAS PubMed Google Scholar
• Lopez T, Hanahan D . (2002). Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 1: 339–353.
  Article CAS PubMed Google Scholar
• Maloney EK, McLaughlin JL, Dagdigian NE, Garrett LM, Connors KM, Zhou XM et al. (2003). An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Res 63: 5073–5083.
  CAS PubMed Google Scholar
• Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD et al. (2005a). Genes that mediate breast cancer metastasis to lung. Nature 436: 518–524.
  Article CAS PubMed PubMed Central Google Scholar
• Minn AJ, Kang Y, Serganova I, Gupta GP, Giri DD, Doubrovin M et al. (2005b). Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest 115: 44–55.
  Article CAS PubMed PubMed Central Google Scholar
• Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME et al. (2001). Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50–56.
  Article CAS PubMed Google Scholar
• Nagle JA, Ma Z, Byrne MA, White MF, Shaw LM . (2004). Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Mol Cell Biol 24: 9726–9735.
  Article CAS PubMed PubMed Central Google Scholar
• Norton L, Massague J . (2006). Is cancer a disease of self-seeding? Nat Med 12: 875–878.
  Article CAS PubMed Google Scholar
• Plymate SR, Bae VL, Maddison L, Quinn LS, Ware JL . (1997). Reexpression of the type 1 insulin-like growth factor receptor inhibits the malignant phenotype of simian virus 40 T antigen immortalized human prostate epithelial cells. Endocrinology 138: 1728–1735.
  Article CAS PubMed Google Scholar
• Plymate SR, Tennant MK, Culp SH, Woodke L, Marcelli M, Colman I et al. (2004). Androgen receptor (AR) expression in AR-negative prostate cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic tumors. Prostate 61: 276–290.
  Article CAS PubMed Google Scholar
• Radisky ES, Radisky DC . (2007). Stromal induction of breast cancer: inflammation and invasion. Rev Endocr Metab Disord 8: 279–287.
  Article PubMed Google Scholar
• Rae JM, Creighton CJ, Meck JM, Haddad BR, Johnson MD . (2007). MDA-MB-435 cells are derived from M14 melanoma cells—a loss for breast cancer, but a boon for melanoma research. Breast Cancer Res Treat 104: 13–19.
  Article PubMed Google Scholar
• Ravid D, Maor S, Werner H, Liscovitch M . (2005). Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. Oncogene 24: 1338–1347.
  Article CAS PubMed Google Scholar
• Reinmuth N, Fan F, Liu W, Parikh AA, Stoeltzing O, Jung YD et al. (2002). Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer. Lab Invest 82: 1377–1389.
  Article CAS PubMed Google Scholar
• Rowinsky EK, Youssoufian H, Tonra JR, Solomon P, Burtrum D, Ludwig DL . (2007). IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor. Clin Cancer Res 13: 5549s–5555s.
  Article CAS PubMed Google Scholar
• Sachdev D, Hartell JS, Lee AV, Zhang X, Yee D . (2004). A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells. J Biol Chem 279: 5017–5024.
  Article CAS PubMed Google Scholar
• Sachdev D, Li SL, Hartell JS, Fujita-Yamaguchi Y, Miller JS, Yee D . (2003). A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I. Cancer Res 63: 627–635.
  CAS PubMed Google Scholar
• Sachdev D, Singh R, Fujita-Yamaguchi Y, Yee D . (2006). Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer. Cancer Res 66: 2391–2402.
  Article CAS PubMed Google Scholar
• Sachdev D, Yee D . (2007). Disrupting insulin-like growth factor signaling as a potential cancer therapy. Mol Cancer Ther 6: 1–12.
  Article CAS PubMed Google Scholar
• Tolcher AW, Patnaik A, Till E, Takimoto CH, Papadopoulos KP, Massard C et al. (2008). A phase I study of AVE1642, a humanized monoclonal antibody IGF-1R (insulin like growth factor1 receptor) antagonist, in patients(pts) with advanced solid tumor(ST). J Clin Oncology 26 (No 15S): 3582.
  Article Google Scholar
• Townson JL, Naumov GN, Chambers AF . (2003). The role of apoptosis in tumor progression and metastasis. Curr Mol Med 3: 631–642.
  Article CAS PubMed Google Scholar
• Twentyman PR, Luscombe M . (1987). A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity. Br J Cancer 56: 279–285.
  Article CAS PubMed PubMed Central Google Scholar
• Valentinis B, Morrione A, Peruzzi F, Prisco M, Reiss K, Baserga R . (1999). Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion. Oncogene 18: 1827–1836.
  Article CAS PubMed Google Scholar
• van Golen CM, Schwab TS, Kim B, Soules ME, Su Oh S, Fung K et al. (2006). Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to bone. Cancer Res 66: 6570–6578.
  Article CAS PubMed Google Scholar
• Wu JD, Haugk K, Coleman I, Woodke L, Vessella R, Nelson P et al. (2006). Combined in vivo effect of A12, a type 1 insulin-like growth factor receptor antibody, and docetaxel against prostate cancer tumors. Clin Cancer Res 12: 6153–6160.
  Article CAS PubMed Google Scholar
• Wu Y, Cui K, Miyoshi K, Hennighausen L, Green JE, Setser J et al. (2003). Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res 63: 4384–4388.
  CAS PubMed Google Scholar
• Wu Y, Yakar S, Zhao L, Hennighausen L, LeRoith D . (2002). Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res 62: 1030–1035.
  CAS PubMed Google Scholar
• Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B et al. (1999). Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA 96: 7324–7329.
  Article CAS PubMed PubMed Central Google Scholar
• Yoneda T, Williams PJ, Hiraga T, Niewolna M, Nishimura R . (2001). A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro. J Bone Miner Res 16: 1486–1495.
  Article CAS PubMed Google Scholar
• Zhang X, Yee D . (2002). Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility. Cancer Res 62: 4369–4375.
  CAS PubMed Google Scholar