Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation (original) (raw)

• Arden KC . (2008). FOXO animal models reveal a variety of diverse roles for FOXO transcription factors. Oncogene 27: 2345–2350.
  Article CAS PubMed Google Scholar
• Biggs III WH, Meisenhelder J, Hunter T, Cavenee WK, Arden KC . (1999). Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 96: 7421–7426.
  Article CAS PubMed PubMed Central Google Scholar
• Borra MT, O'Neill FJ, Jackson MD, Marshall B, Verdin E, Foltz KR et al. (2002). Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. J Biol Chem 277: 12632–12641.
  Article CAS PubMed Google Scholar
• Brummelkamp TR, Bernards R, Agami R . (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550–553.
  Article CAS PubMed Google Scholar
• Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS et al. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857–868.
  Article CAS PubMed Google Scholar
• Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y et al. (2004). Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011–2015.
  Article CAS PubMed Google Scholar
• Chan CH, Lee SW, Wang J, Lin HK . (2010). Regulation of Skp2 expression and activity and its role in cancer progression. ScientificWorldJournal 10: 1001–1015.
  Article CAS PubMed PubMed Central Google Scholar
• Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P et al. (2003). Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci USA 100: 10794–10799.
  Article CAS PubMed PubMed Central Google Scholar
• Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B et al. (2004). Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390–392.
  Article CAS PubMed Google Scholar
• Daitoku H, Hatta M, Matsuzaki H, Aratani S, Ohshima T, Miyagishi M et al. (2004). Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci USA 101: 10042–10047.
  Article CAS PubMed PubMed Central Google Scholar
• Dansen TB, Burgering BM . (2008). Unravelling the tumor-suppressive functions of FOXO proteins. Trends Cell Biol 18: 421–429.
  Article CAS PubMed Google Scholar
• Deng CX . (2009). SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci 5: 147–152.
  Article CAS PubMed PubMed Central Google Scholar
• Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL et al. (2004). FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 23: 4802–4812.
  Article CAS PubMed PubMed Central Google Scholar
• Finnin MS, Donigian JR, Pavletich NP . (2001). Structure of the histone deacetylase SIRT2. Nat Struct Biol 8: 621–625.
  Article CAS PubMed Google Scholar
• Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S et al. (2009). MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem 284: 13987–14000.
  Article CAS PubMed PubMed Central Google Scholar
• Fu Z, Tindall DJ . (2008). FOXOs, cancer and regulation of apoptosis. Oncogene 27: 2312–2319.
  Article CAS PubMed PubMed Central Google Scholar
• Fukuoka M, Daitoku H, Hatta M, Matsuzaki H, Umemura S, Fukamizu A . (2003). Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation. Int J Mol Med 12: 503–508.
  CAS PubMed Google Scholar
• Gross DN, van den Heuvel AP, Birnbaum MJ . (2008). The role of FoxO in the regulation of metabolism. Oncogene 27: 2320–2336.
  Article CAS PubMed Google Scholar
• Haigis MC, Guarente LP . (2006). Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev 20: 2913–2921.
  Article CAS PubMed Google Scholar
• Hiratsuka M, Inoue T, Toda T, Kimura N, Shirayoshi Y, Kamitani H et al. (2003). Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem Biophys Res Commun 309: 558–566.
  Article CAS PubMed Google Scholar
• Ho KK, Myatt SS, Lam EW . (2008). Many forks in the path: cycling with FoxO. Oncogene 27: 2300–2311.
  Article CAS PubMed Google Scholar
• Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY et al. (2004). IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117: 225–237.
  Article CAS PubMed Google Scholar
• Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen JM et al. (2005). Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci USA 102: 1649–1654.
  Article CAS PubMed PubMed Central Google Scholar
• Jing E, Gesta S, Kahn CR . (2007). SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab 6: 105–114.
  Article CAS PubMed PubMed Central Google Scholar
• Jordan M, Schallhorn A, Wurm FM . (1996). Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res 24: 596–601.
  Article CAS PubMed PubMed Central Google Scholar
• Kabra N, Li Z, Chen L, Li B, Zhang X, Wang C et al. (2009). SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem 284: 18210–18217.
  Article CAS PubMed PubMed Central Google Scholar
• Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, Dang N et al. (2005). Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 1: e69.
  Article PubMed PubMed Central Google Scholar
• Kaeberlein M, Kirkland KT, Fields S, Kennedy BK. . (2004). Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2: E296.
  Article PubMed PubMed Central Google Scholar
• Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, Gu W et al. (2005). FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab 2: 153–163.
  Article CAS PubMed Google Scholar
• Kojima K, Ohhashi R, Fujita Y, Hamada N, Akao Y, Nozawa Y et al. (2008). A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells. Biochem Biophys Res Commun 373: 423–428.
  Article CAS PubMed Google Scholar
• Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM. . (1999). Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398: 630–634.
  Article CAS PubMed Google Scholar
• Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C et al. (2005). HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 309: 1861–1864.
  Article CAS PubMed Google Scholar
• Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, Becker EB et al. (2006). A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125: 987–1001.
  Article CAS PubMed Google Scholar
• Libina N, Berman JR, Kenyon C . (2003). Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115: 489–502.
  Article CAS PubMed Google Scholar
• Liu T, Liu PY, Marshall GM . (2009). The critical role of the class III histone deacetylase SIRT1 in cancer. Cancer Res 69: 1702–1705.
  Article CAS PubMed Google Scholar
• Makarova O, Kamberov E, Margolis B . (2000). Generation of deletion and point mutations with one primer in a single cloning step. Biotechniques 29: 970–972.
  Article CAS PubMed Google Scholar
• Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, Fukamizu A . (2005). Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci USA 102: 11278–11283.
  Article CAS PubMed PubMed Central Google Scholar
• Matsuzaki H, Daitoku H, Hatta M, Tanaka K, Fukamizu A . (2003). Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci USA 100: 11285–11290.
  Article CAS PubMed PubMed Central Google Scholar
• Modur V, Nagarajan R, Evers BM, Milbrandt J . (2002). FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J Biol Chem 277: 47928–47937.
  Article CAS PubMed Google Scholar
• Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W et al. (2004). Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551–563.
  Article CAS PubMed Google Scholar
• Obsil T, Obsilova V . (2008). Structure/function relationships underlying regulation of FOXO transcription factors. Oncogene 27: 2263–2275.
  Article CAS PubMed Google Scholar
• Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA . (2005). JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci USA 102: 4494–4499.
  Article CAS PubMed PubMed Central Google Scholar
• Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z et al. (2007). FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128: 309–323.
  Article CAS PubMed PubMed Central Google Scholar
• Perrot V, Rechler MM . (2005). The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription. Mol Endocrinol 19: 2283–2298.
  Article CAS PubMed Google Scholar
• Pickart CM . (2001). Mechanisms underlying ubiquitination. Annu Rev Biochem 70: 503–533.
  Article CAS PubMed Google Scholar
• Plas DR, Thompson CB . (2003). Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J Biol Chem 278: 12361–12366.
  Article CAS PubMed Google Scholar
• Ravid T, Hochstrasser M . (2007). Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Nat Cell Biol 9: 422–427.
  Article CAS PubMed Google Scholar
• Rena G, Guo S, Cichy SC, Unterman TG, Cohen P . (1999). Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem 274: 17179–17183.
  Article CAS PubMed Google Scholar
• Schwer B, Verdin E . (2008). Conserved metabolic regulatory functions of sirtuins. Cell Metab 7: 104–112.
  Article CAS PubMed Google Scholar
• Sedding DG . (2008). FoxO transcription factors in oxidative stress response and ageing—a new fork on the way to longevity? Biol Chem 389: 279–283.
  Article CAS PubMed Google Scholar
• Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed SI . (2001). Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413: 316–322.
  Article CAS PubMed Google Scholar
• Sun Y . (2006). E3 ubiquitin ligases as cancer targets and biomarkers. Neoplasia 8: 645–654.
  Article CAS PubMed PubMed Central Google Scholar
• Sung JY, Kim R, Kim JE, Lee J . (2010). Balance between SIRT1 and DBC1 expression is lost in breast cancer. Cancer Sci 101: 1738–1744.
  Article CAS PubMed Google Scholar
• Takaishi H, Konishi H, Matsuzaki H, Ono Y, Shirai Y, Saito N et al. (1999). Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. Proc Natl Acad Sci USA 96: 11836–11841.
  Article CAS PubMed PubMed Central Google Scholar
• Tedesco D, Lukas J, Reed SI . (2002). The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). Genes Dev 16: 2946–2957.
  Article CAS PubMed PubMed Central Google Scholar
• Tissenbaum HA, Guarente L . (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227–230.
  Article CAS PubMed Google Scholar
• van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F et al. (2006). FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat Cell Biol 8: 1064–1073.
  Article CAS PubMed Google Scholar
• van der Horst A, Tertoolen LG, de Vries-Smits LM, Frye RA, Medema RH, Burgering BM . (2004). FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem 279: 28873–28879.
  Article CAS PubMed Google Scholar
• Verdin E . (2007). AROuSing SIRT1: identification of a novel endogenous SIRT1 activator. Mol Cell 28: 354–356.
  Article CAS PubMed Google Scholar
• Wang F, Nguyen M, Qin FX, Tong Q . (2007). SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6: 505–514.
  Article CAS PubMed Google Scholar
• Wang F, Tong Q . (2009). SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell 20: 801–808.
  Article CAS PubMed PubMed Central Google Scholar
• Wang J, Chen J . (2010). SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem 285: 11458–11464.
  Article CAS PubMed PubMed Central Google Scholar
• Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X et al. (2008). ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol 10: 138–148.
  Article CAS PubMed PubMed Central Google Scholar
• Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B et al. (2009). The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325: 1134–1138.
  Article CAS PubMed PubMed Central Google Scholar
• Yang Y, Hou H, Haller EM, Nicosia SV, Bai W . (2005). Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J 24: 1021–1032.
  Article CAS PubMed PubMed Central Google Scholar
• Zou Y, Tsai WB, Cheng CJ, Hsu C, Chung YM, Li PC et al. (2008). Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis. Breast Cancer Res 10: R21.
  Article PubMed PubMed Central Google Scholar