Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway (original) (raw)

• Kern SE, Shi C, Hruban RH . The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting. J Pathol 2011; 223: 295–306.
  Article CAS PubMed Google Scholar
• Falasca M, Selvaggi F, Buus R, Sulpizio S, Edling CE . Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signaling to clinical trials. Anticancer Agents Med Chem 2011; 11: 455–463.
  Article CAS PubMed Google Scholar
• Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H et al. Activation of Akt and eIF4E survival pathways by rapamycin mediated mammalian target of rapamycin inhibition. Cancer Res 2005; 65: 7052–7058.
  Article CAS PubMed Google Scholar
• Wang X, Yue P, Chan C, Ye K, Ueda T, Watanabe-Fukunaga R et al. Inhibition of Mammalian Target of Rapamycin Induces Phosphatidylinositol 3-Kinase Dependent and Mnk-Mediated Eukaryotic Translation Initiation Factor 4E Phosphorylation. Mol Cell Biol 2007; 27: 7405–7413.
  Article CAS PubMed PubMed Central Google Scholar
• Zoncu R, Efeyan A, Sabatini DM . mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21–35.
  Article CAS PubMed Google Scholar
• Culjkovic B, Topisirovic I, Skrabanek L, Ruiz-Gutierrez M, Borden KL . eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′ UTR. J Cell Biol 2005; 169: 245–256.
  Article CAS PubMed PubMed Central Google Scholar
• Mamane Y, Petroulakis E, Rong L, Yoshida K, Ler LW, Sonenberg N . eIF4E – from translation to transformation. Oncogene 2004; 23: 3172–3179.
  Article CAS PubMed Google Scholar
• Ueda T, Watanabe-Fukunaga R, Fukuyama H, Fukuyama H, Nagata S, Fukunaga R . Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol 2004; 24: 6539–6654.
  Article CAS PubMed PubMed Central Google Scholar
• Buxade M, Parra-Palau JL, Proud CG . The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). Front Biosci 2008; 13: 5359–5373.
  Article CAS PubMed Google Scholar
• Zhang Y, Li Y, Yang D . Phosphorylation of eIF-4E positively regulates formation of the eIF-4F translation initiation complex following DNA damage. Biochem Biophys Res Commun 2008; 367: 54–59.
  Article CAS PubMed Google Scholar
• Bianchini A, Loiarro M, Bielli P, Busà R, Paronetto MP, Loreni F et al. Phosphorylation of eIF4E supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells. Carcinogenesis 2008; 29: 2279–2288.
  Article CAS PubMed Google Scholar
• Konicek BW, Stephens JR, McNulty AM, Robichaud N, Peery RB, Dumstorf CA et al. Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Res 2011; 71: 1849–1857.
  Article CAS PubMed Google Scholar
• Altman JK, Glaser H, Sassano A, Joshi S, Ueda T, Watanabe-Fukunaga R et al. Negative Regulatory Effects of Mnk Kinases in the Generation of Chemotherapy-Induced Antileukemic Responses. Mol Pharmacol 2010; 78: 778–784.
  Article CAS PubMed PubMed Central Google Scholar
• Wendel HG, Silva RL, Malina A, Mills JR, Zhu H, Ueda T et al. Dissecting eIF4E action in tumorigenesis. Genes Dev 2007; 21: 3232–3237.
  Article CAS PubMed PubMed Central Google Scholar
• Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A et al. eIF4E phopshorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci USA 2010; 107: 14134–14139.
  Article CAS PubMed PubMed Central Google Scholar
• Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R et al. Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc Natl Acad Sci USA 2010; 107: 13984–13990.
  Article CAS PubMed PubMed Central Google Scholar
• Graff JR, Konicek BW, Lynch RL, Dumstorf CA, Dowless MS, McNulty AM et al. eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival. Cancer Res 2009; 69: 3866–3873.
  Article CAS PubMed Google Scholar
• Yoshizawa A, Fukuoka J, Shimizu S, Shilo K, Franks TJ, Hewitt SM et al. Overexpression of phopsho-eIF4E is associated with survival through AKT pathway in non-small-cell lung cancer. Clin Cancer Res 2010; 16: 240–248.
  Article CAS PubMed Google Scholar
• Chrestensen CA, Eschenroeder A, Ross WG, Ueda T, Watanabe-Fukunaga R, Fukunaga R et al. Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis. Genes Cells 2007; 12: 1133–1140.
  Article CAS PubMed Google Scholar
• Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG et al. The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization. Mol Cell Biol 2003; 23: 5692–5705.
  Article CAS PubMed PubMed Central Google Scholar
• Karni R, De Stanchina E, Lowe SW, Sinha R, Mu D, Krainer AR . The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol 2007; 14: 185–193.
  Article CAS PubMed PubMed Central Google Scholar
• David CJ, Chen M, Assanah M, Canoll P, Manley JL . HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 2010; 463: 364–368.
  Article CAS PubMed Google Scholar
• Bielli P, Busà R, Paronetto MP, Sette C . The RNA-binding protein Sam68 is a multifunctional player in human cancer. Endocr Relat Cancer 2011; 18: 91–102.
  Article Google Scholar
• Assouline S, Culjkovic B, Cocolakis E, Rousseau C, Beslu N, Amri A et al. Molecular targeting of the oncogene eIF4E in AML: a proof-of principle clinical trial with ribavirin. Blood 2009; 114: 257–260.
  Article CAS PubMed Google Scholar
• Wolpin BM, Hezel AF, Abrams T, Blaszkowsky LS, Meyerhardt JA, Chan JA et al. Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer. J Clin Oncol 2008; 27: 193–198.
  Article PubMed Google Scholar
• Gonçalves V, Theisen P, Antunes O, Medeira A, Ramos JS, Jordan P et al. A missense mutation in the APC tumor suppressor gene disrupts an ASF/SF2 splicing enhancer motif and causes pathogenic skipping of exon 14. Mutat Res 2009; 662: 33–36.
  Article PubMed Google Scholar
• Sanz DJ, Acedo A, Infante M, Durán M, Pérez-Cabornero L, Esteban-Cardeñosa E et al. A high proportion of DNA variants of BRCA1 and BRCA2 is associated with aberrant splicing in breast/ovarian cancer patients. Clin Cancer Res 2010; 16: 1957–1967.
  Article CAS PubMed Google Scholar
• Hayes GM, Carrigan PE, Miller LJ . Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas. Cancer Res 2007; 67: 2072–2080.
  Article CAS PubMed Google Scholar
• Hayes GM, Carrigan PE, Beck AM, Miller LJ . Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma. Cancer Res 2006; 66: 3819–3827.
  Article CAS PubMed Google Scholar
• Busà R, Paronetto MP, Farini D, Pierantozzi E, Botti F, Angelini DF et al. The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells. Oncogene 2007; 26: 4372–4382.
  Article PubMed Google Scholar
• Pedrotti S, Bielli P, Paronetto MP, Ciccosanti F, Fimia GM, Stamm S et al. The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J 2010; 29: 1235–1247.
  Article CAS PubMed PubMed Central Google Scholar
• O’Loghlen A, Gonzalez VM, Pineiro D, Pérez-Morgado MI, Salinas M, Martín ME . Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1. Experimental Cell Res 2004; 299: 343–355.
  Article Google Scholar