Endothelial CXCR7 regulates breast cancer metastasis (original) (raw)

• Balkwill F . Cancer and the chemokine network. Nat Rev Cancer 2004; 4: 540–550.
  Article CAS PubMed Google Scholar
• Ali S, Lazennec G . Chemokines: novel targets for breast cancer metastasis. Cancer Metastasis Rev 2007; 26: 401–420.
  Article CAS PubMed PubMed Central Google Scholar
• Teicher B, Fricker S . CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 2010; 16: 2927–2931.
  Article CAS PubMed Google Scholar
• Orimo A, Gupta P, Sgroi D, Arenzana-Seisdedos F, Delaunay T, Naeem R et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005; 121: 335–348.
  CAS PubMed Google Scholar
• Zhang X, Jin X, Malladi S, Zou Y, Wen Y, Brogi E et al. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell 2013; 154: 1060–1073.
  Article CAS PubMed PubMed Central Google Scholar
• Muller A, Homey B, Soto H, Ge N, Catron D, Buchanon M et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001; 410: 50–56.
  Article CAS PubMed Google Scholar
• Singh S, Srivastava S, Bhardwaj A, Owen L, Singh A . CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy. Br J Cancer 2010; 103: 1671–1679.
  Article CAS PubMed PubMed Central Google Scholar
• Hoellenriegel J, Zboralski D, Maasch C, Rosin N, Wierda W, Keating M et al. The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization. Blood 2014; 123: 1032–1039.
  Article CAS PubMed PubMed Central Google Scholar
• Akashi T, Koizumi K, Tsuneyama K, Saiki I, Takano Y, Fuse H . Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer. Cancer Sci 2008; 99: 539–542.
  Article CAS PubMed Google Scholar
• Xu T, Shen H, Liu L, Shu Y . The impact of chemokine receptor CXCR4 on breast cancer prognosis: a meta-analysis. Cancer Epidemiol 2013; 37: 725–731.
  Article CAS PubMed Google Scholar
• Wald O, Shapira O, Izhar U . CXCR4/CXCL12 axis in non small cell lung cancer (NSCLC) pathologic roles and therapeutic potential. Theranostics 2013; 3: 26–33.
  Article CAS PubMed PubMed Central Google Scholar
• Miao Z, Luker K, Summers B, Berahovich R, Bhojani M, Rehemtulla A et al. CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc Natl Acad Sci USA 2007; 104: 15735–15740.
  Article CAS PubMed PubMed Central Google Scholar
• Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta K et al. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem 2008; 283: 4283–4294.
  Article CAS PubMed Google Scholar
• Yao X, Zhou L, Han S, Chen Y . High expression of CXCR4 and CXCR7 predicts poor survival in gallbladder cancer. J Int Med Res 2011; 39: 1253–1264.
  Article CAS PubMed Google Scholar
• D'Alterio C, Consales C, Polimeno M, Franco R, Cindolo L, Portella L et al. Concomitant CXCR4 and CXCR7 expression predicts poor prognosis in renal cancer. Curr Cancer Drug Targets 2010; 10: 772–781.
  Article CAS PubMed Google Scholar
• Tachezy M, Zander H, Gebauer F, von Loga K, Pantel K, Izbicki J et al. CXCR7 expression in esophageal cancer. J Transl Med 2013; 11: 238.
  Article PubMed PubMed Central Google Scholar
• Liberman J, Sartelet H, Flahaut M, Muhlethaler-Mottet A, Coulon A, Nyalendo C et al. Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma. PLoS One 2012; 7: e43665.
  Article CAS PubMed PubMed Central Google Scholar
• D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L et al. A prognostic model comprising pT stage, N status and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neo-adjuvant resistant rectal cancer patients. Int J Cancer 2013; 135: 379–390.
  Article Google Scholar
• Sierro F, Biben C, Martinez-Munoz L, Mellado M, Ransohoff R, Li M et al. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci USA 2007; 104: 14759–14764.
  Article CAS PubMed PubMed Central Google Scholar
• Gerrits H, van Ingen Schenau D, Bakker N, van Disseldorp A, Strik A, Hermens L et al. Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice. Genesis 2008; 46: 235–245.
  Article CAS PubMed Google Scholar
• Madden S, Cook B, Nacht M, Weber W, Callahan M, Jiang Y et al. Vascular gene expression in nonneoplastic and malignant brain. Am J Pathol 2004; 165: 601–608.
  Article CAS PubMed PubMed Central Google Scholar
• Maishi N, Ohga N, Hida Y, Akiyama K, Kitayama K, Osawa T et al. CXCR7: a novel tumor endothelial marker in renal cell carcinoma. Pathol Int 2012; 62: 309–317.
  Article CAS PubMed Google Scholar
• Gőthert J, Gustin S, Hall M, Green A, Gőttgens B, Izon D et al. In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis. Blood 2005; 105: 2724–2732.
  Article PubMed Google Scholar
• Liao Y, Day K, Damon D, Duling B . Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice. Proc Natl Acad Sci USA 2001; 98: 9989–9994.
  Article CAS PubMed PubMed Central Google Scholar
• Suárez Y, Fernández-Hernando C, Yu J, Gerber S, Harrison K, Pober J et al. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci USA 2008; 105: 14082–14087.
  Article PubMed PubMed Central Google Scholar
• Ding B-S, Cao Z, Lis R, Nolan D, Guo P, Simons M et al. Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature 2013; 505: 97–102.
  Article CAS PubMed PubMed Central Google Scholar
• Boldajipour B, Mahabaleshwar S, Kardash E, Reichman-Fried M, Blaser H, Minina S et al. Control of chemokine-guided cell migration by ligand sequestration. Cell 2008; 132: 463–473.
  Article CAS PubMed Google Scholar
• Luker K, Steele J, Mihalko L, Luker G . Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands. Oncogene 2010; 29: 4599–4610.
  Article CAS PubMed PubMed Central Google Scholar
• Coleman R . Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res 2006; 12: 6243s–6249s.
  Article PubMed Google Scholar
• Ewens A, Mihich E, Ehrke M . Distant metastasis from subcutaneously grown E0771 medullary breast adenocarcinoma. Anticancer Res 2005; 25: 3905–3915.
  PubMed Google Scholar
• Luker K, Lewin S, Mihalko L, Schmidt B, Winkler J, Coggins N et al. Scavenging of CXCL12 by CXCR7 regulates tumor growth and metastasis of CXCR4-positive breast cancer cells. Oncogene 2012; 31: 4570–4578.
  Article Google Scholar
• Guillemot E, Karimdjee-Soilhi B, Pradelli E, Benchetrit M, Goquet-Surmenian E, Millet M et al. CXCR7 receptors facilitate the progression of colon carcinoma within lung not within liver. Br J Cancer 2012; 107: 1944–1949.
  Article CAS PubMed PubMed Central Google Scholar
• Dang S, Peng Y, Ye L, Wang Y, Qian Z, Chen Y et al. Stimulation of TLR4 by LMW-HA induces metastasis in human papillary thyroid carcinoma through CXCR7. Clin Dev Immunol 2013; 2013: 712561.
  PubMed PubMed Central Google Scholar
• Xue T, Chen R, Han D, Chen J, Xue Q, Gao D et al. Down-regulation of CXCR7 inhibits the growth and lung metastasis of human hepatocellular carcinoma cells with highly metastatic potential. Exp Ther Med 2012; 3: 117–123.
  Article CAS PubMed Google Scholar
• Burns J, Summers B, Wang Y, Melikian A, Berahovich R, Miao Z et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med 2006; 203: 2201–2213.
  Article CAS PubMed PubMed Central Google Scholar
• Goquet-Surmenian E, Richard-Fiardo P, Guillemot E, Benchetrit M, Gomez-Brouchet A, Buzzo P et al. CXCR7-mediated progression of osteosarcoma in the lungs. Br J Cancer 2013; 109: 1579–1585.
  Article Google Scholar
• Walters M, Ebsworth K, Berahovich R, Penfold M, Liu S, Al Omran R et al. Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats. Br J Cancer 2014; 110: 1179–1188.
  Article CAS PubMed PubMed Central Google Scholar
• Berahovich R, Zabel B, Lewen S, Walters M, Ebsworth K, Wang Y et al. Endothelial expression of CXCR7 and the regulation of systemic CXCL12 levels. Immunology 2014; 141: 111–122.
  Article CAS PubMed Google Scholar
• Wang Y, Li G, Stanco A, Long J, Crawford D, Potter G et al. CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Neuron 2011; 69: 61–76.
  Article CAS PubMed PubMed Central Google Scholar
• Sanchez-Alcaniz J, Haege S, Mueller W, Pla R, Mackay F, Schulz S et al. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron 2011; 69: 77–90.
  Article CAS PubMed Google Scholar
• Dona E, Barry J, Valentin G, Quirin C, Khmelinskii A, Kunze A et al. Directional tissue migration through a self-generated chemokine gradient. Nature 2013; 503: 285–289.
  Article CAS PubMed Google Scholar
• Venkiteswaran G, Lewellis S, Wang J, Reynolds E, Nicholson C, Knaut H . Generation and dynamics of an endogenous, self-generated signaling gradient across a migrating tissue. Cell 2013; 155: 674–687.
  Article CAS PubMed Google Scholar
• Cavnar S, Ray P, Moudgil P, Chang S, Luker K, Linderman J et al. Microfluidic source-sink model reveals effects of biophysically distinct CXCL12-isoforms in breast cancer chemotaxis. Integr Biol 2014; 6: 564–576.
  Article CAS Google Scholar
• Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H et al. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 2004; 6: 17–32.
  Article CAS PubMed Google Scholar
• Potter S, Dwyer R, Curran C, Hennesy E, Harrington K, Griffin D et al. Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones. Breast Cancer Res Treat 2009; 115: 279–287.
  Article CAS PubMed Google Scholar
• Zabel B, Wang Y, Lewen S, Berahovich R, Penfold M, Zhang P et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol 2009; 183: 3204–3211.
  Article CAS PubMed Google Scholar
• Kochetkova M, Kumar S, McColl S . Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells. Cell Death Differ 2009; 16: 664–673.
  Article CAS PubMed Google Scholar
• Sun Y, Mao X, Fan C, Liu C, Guo A, Guan S et al. CXCL12-CXCR4 axis promotes the natural selection of breast cancer cell metastasis. Tumour Biol 2014; 35: 7765–7773.
  Article CAS PubMed Google Scholar
• Cruz-Orengo L, Holman D, Dorsey D, Zhou L, Zhang P, Wright M et al. CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity. J Exp Med 2011; 208: 327–339.
  Article CAS PubMed PubMed Central Google Scholar
• Kitamura T, Qian B-Z, Pollard J . Immune cell promotion of metastasis. Nat Rev Immunol 2015; 15: 73–86.
  Article CAS PubMed PubMed Central Google Scholar
• Raggo C, Ruhl R, McAllister S, Koon H, Dezube B, Fruh K et al. Novel cellular genes essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus. Cancer Res 2005; 65: 5084–5095.
  Article CAS PubMed Google Scholar
• Totonchy J, Osborn J, Botto S, Clepper L, Moses A . Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein. PLoS One 2013; 8: e69828.
  Article CAS PubMed PubMed Central Google Scholar
• Casanovas O, Hicklin D, Bergers G, Hanahan D . Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005; 8: 299–309.
  Article CAS PubMed Google Scholar
• Nanda A, Karim B, Peng Z, Liu G, Qiu W, Gan C et al. Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. Proc Natl Acad Sci USA 2006; 103: 3351–3356.
  Article CAS PubMed PubMed Central Google Scholar
• Cullen M, Seaman S, Chaudhary A, Yang M, Hilton M, Logsdon D et al. Host-derived tumor endothelial marker 8 promotes the growth of melanoma. Cancer Res 2009; 69: 6021–6026.
  Article CAS PubMed PubMed Central Google Scholar
• Yokoyama K, Ishikawa N, Igarahsi S, Kawano N, Hattori K, Miyazaki T et al. Discovery of potent CCR4 antagonists: synthesis and structure-activity relationship study of 2,4-diaminoquinazolines. Bioorg Med Chem 2008; 16: 7021–7031.
  Article CAS PubMed Google Scholar
• Walters M, Ebsworth K, Sullivan T, Zhang P, Powers J, Jaen J et al. CCR9 inhibition does not interfere with the development of immune tolerance to oral antigens. Immunol Lett 2013; 151: 44–47.
  Article CAS PubMed Google Scholar
• Smith M, Luker K, Garbow J, Prior J, Jackson E, Piwnica-Worms D et al. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 2004; 64: 8604–8612.
  Article CAS PubMed Google Scholar
• Ray P, Mihalko L, Coggins N, Moudgil P, Ehrlich A, Luker K et al. Carboxy-terminus of CXCR7 regulates receptor localization and function. Int J Biochem Cell Biol 2012; 44: 669–678.
  Article CAS PubMed PubMed Central Google Scholar
• Luker G, Pica C, Song J, Luker K, Piwnica-Worms D . Imaging 26 S proteasome activity and inhibition in living mice. Nat Med 2003; 9: 969–973.
  Article CAS PubMed Google Scholar
• Fenner J, Stacer A, Winterroth F, Johnson T, Luker K, Luker G . Macroscopic stiffness of breast tumors predicts metastasis. Sci Rep 2014; 4: 5512.
  Article CAS PubMed PubMed Central Google Scholar
• Salomonnson E, Stacer A, Ehrlich A, Luker K, Luker G . Imaging CXCL12-CXCR4 signaling in ovarian cancer therapy. PLoS One 2013; 8: e51500.
  Article CAS PubMed PubMed Central Google Scholar
• Zhao S, Chang S, Linderman J, Feng F, Luker G . A comprehensive analysis of CXCL12 isoforms in breast cancer. Transl Oncol 2014; 7: 429–438.
  Article PubMed Central Google Scholar
• Subramanian A, Tamayo P, Mootha V, Mukherjee S, Ebert B, Gillette M et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102: 15545–15550.
  Article CAS PubMed PubMed Central Google Scholar