Co-active receptor tyrosine kinases mitigate the effect of FGFR inhibitors in FGFR1-amplified lung cancers with low FGFR1 protein expression (original) (raw)
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129–2139. ArticleCAS Google Scholar
Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007; 448: 561–566. ArticleCAS Google Scholar
Meador CB, Micheel CM, Levy MA, Lovly CM, Horn L, Warner JL et al. Beyond histology: translating tumor genotypes into clinically effective targeted therapies. Clin Cancer Res 2014; 20: 2264–2275. ArticleCAS Google Scholar
Gandara DR, Hammerman PS, Sos ML, Lara PN Jr, Hirsch FR . Squamous cell lung cancer: from tumor genomics to cancer therapeutics. Clin Cancer Res 2015; 21: 2236–2243. ArticleCAS Google Scholar
Dieci MV, Arnedos M, Andre F, Soria JC . Fibroblast growth factor receptor inhibitors as a cancer treatment: from a biologic rationale to medical perspectives. Cancer Discov 2013; 3: 264–279. ArticleCAS Google Scholar
Brooks AN, Kilgour E, Smith PD . Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer. Clin Cancer Res 2012; 18: 1855–1862. ArticleCAS Google Scholar
Dienstmann R, Rodon J, Prat A, Perez-Garcia J, Adamo B, Felip E et al. Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors. Ann Oncol 2014; 25: 552–563. ArticleCAS Google Scholar
Weiss J, Sos ML, Seidel D, Peifer M, Zander T, Heuckmann JM et al. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med 2010; 2: 62ra93. ArticleCAS Google Scholar
Dutt A, Ramos AH, Hammerman PS, Mermel C, Cho J, Sharifnia T et al. Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PLoS One 2011; 6: e20351. ArticleCAS Google Scholar
Heist RS, Mino-Kenudson M, Sequist LV, Tammireddy S, Morrissey L, Christiani DC et al. FGFR1 amplification in squamous cell carcinoma of the lung. J Thorac Oncol 2012; 7: 1775–1780. ArticleCAS Google Scholar
Schildhaus HU, Heukamp LC, Merkelbach-Bruse S, Riesner K, Schmitz K, Binot E et al. Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer. Mod Pathol 2012; 25: 1473–1480. ArticleCAS Google Scholar
Kohler LH, Mireskandari M, Knosel T, Altendorf-Hofmann A, Kunze A, Schmidt A et al. FGFR1 expression and gene copy numbers in human lung cancer. Virchows Arch 2012; 461: 49–57. ArticleCAS Google Scholar
Kim HR, Kim DJ, Kang DR, Lee JG, Lim SM, Lee CY et al. Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer. J Clin Oncol 2013; 31: 731–737. Article Google Scholar
Tran TN, Selinger CI, Kohonen-Corish MR, McCaughan BC, Kennedy CW, O'Toole SA et al. Fibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancer. Lung Cancer 2013; 81: 462–467. Article Google Scholar
Seo AN, Jin Y, Lee HJ, Sun PL, Kim H, Jheon S et al. FGFR1 amplification is associated with poor prognosis and smoking in non-small-cell lung cancer. Virchows Arch 2014; 465: 547–558. ArticleCAS Google Scholar
Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012; 489: 519–525. Article Google Scholar
Helsten T, Elkin S, Arthur E, Tomson BN, Carter J, Kurzrock R . The FGFR landscape in cancer: analysis of 4853 tumors by next generation sequencing. Clin Cancer Res 2015; e-pub ahead of print 15 September 2015.
Nogova L, Sequist LV, Cassier PA, Hidalgo M, Delord JP, Schuler MH et al. Targeting FGFR1-amplified lung squamous cell carcinoma with the selective pan-FGFR inhibitor BGJ398. J Clin Oncol 2014; 32 (suppl): abstr 8034. Article Google Scholar
Paik PK, Shen R, Ferry D, Soria JC, Mathewson A, Kilgour E et al. A phase 1b open-label multicenter study of AZD4547 in patients with advanced squamous cell lung cancers: Preliminary antitumor activity and pharmacodynamic data. J Clin Oncol 2014; 32 (suppl); abstr 8035. Article Google Scholar
Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001; 344: 783–792. ArticleCAS Google Scholar
Engelman JA, Janne PA . Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res 2008; 14: 2895–2899. Article Google Scholar
Faber AC, Li D, Song Y, Liang MC, Yeap BY, Bronson RT et al. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc Natl Acad Sci USA 2009; 106: 19503–19508. ArticleCAS Google Scholar
Laplante M, Sabatini DM . mTOR signaling at a glance. J Cell Sci 2009; 122: 3589–3594. ArticleCAS Google Scholar
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 2007; 131: 1190–1203. ArticleCAS Google Scholar
McDermott U, Ames RY, Iafrate AJ, Maheswaran S, Stubbs H, Greninger P et al. Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors. Cancer Res 2009; 69: 3937–3946. ArticleCAS Google Scholar
Lewis Phillips GD, Li G, Dugger DL, Crocker LM, Parsons KL, Mai E et al. Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res 2008; 68: 9280–9290. ArticleCAS Google Scholar
Wilson TR, Lee DY, Berry L, Shames DS, Settleman J . Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers. Cancer Cell 2011; 20: 158–172. ArticleCAS Google Scholar
Hata AN, Engelman JA, Faber AC . The BCL2 family: key mediators of the apoptotic response to targeted anticancer therapeutics. Cancer Discov 2015; 5: 475–487. ArticleCAS Google Scholar
Wynes MW, Hinz TK, Gao D, Martini M, Marek LA, Ware KE et al. FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies. Clin Cancer Res 2014; 20: 3299–3309. ArticleCAS Google Scholar
Zhang J, Zhang L, Su X, Li M, Xie L, Malchers F et al. Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models. Clin Cancer Res 2012; 18: 6658–6667. ArticleCAS Google Scholar
Robertson KD . DNA methylation, methyltransferases, and cancer. Oncogene 2001; 20: 3139–3155. ArticleCAS Google Scholar
Montenegro MF, Sanchez-del-Campo L, Fernandez-Perez MP, Saez-Ayala M, Cabezas-Herrera J, Rodriguez-Lopez JN . Targeting the epigenetic machinery of cancer cells. Oncogene 2015; 34: 135–143. ArticleCAS Google Scholar
Guagnano V, Kauffmann A, Wohrle S, Stamm C, Ito M, Barys L et al. FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor. Cancer Discov 2012; 2: 1118–1133. ArticleCAS Google Scholar
Gavine PR, Mooney L, Kilgour E, Thomas AP, Al-Kadhimi K, Beck S et al. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res 2012; 72: 2045–2056. ArticleCAS Google Scholar
O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell 2009; 16: 401–412. ArticleCAS Google Scholar
Terai H, Soejima K, Yasuda H, Nakayama S, Hamamoto J, Arai D et al. Activation of the FGF2-FGFR1 autocrine pathway: a novel mechanism of acquired resistance to gefitinib in NSCLC. Mol Cancer Res 2013; 11: 759–767. ArticleCAS Google Scholar
Harbinski F, Craig VJ, Sanghavi S, Jeffery D, Liu L, Sheppard KA et al. Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth. Cancer Discov 2012; 2: 948–959. ArticleCAS Google Scholar
Wang J, Mikse O, Liao RG, Li Y, Tan L, Janne PA et al. Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells. Oncogene 2015; 34: 2167–2177. ArticleCAS Google Scholar
Wolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, Allison KH et al. Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update. J Clin Oncol 2013; 31: 3997–4013. Article Google Scholar
Pros E, Lantuejoul S, Sanchez-Verde L, Castillo SD, Bonastre E, Suarez-Gauthier A et al. Determining the profiles and parameters for gene amplification testing of growth factor receptors in lung cancer. Int J Cancer 2013; 133: 898–907. ArticleCAS Google Scholar
Malchers F, Dietlein F, Schottle J, Lu X, Nogova L, Albus K et al. Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer. Cancer Discov 2014; 4: 246–257. ArticleCAS Google Scholar
Turner N, Grose R . Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer 2010; 10: 116–129. ArticleCAS Google Scholar
Kunii K, Davis L, Gorenstein J, Hatch H, Yashiro M, Di Bacco A et al. FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. Cancer Res 2008; 68: 2340–2348. ArticleCAS Google Scholar
Herbst RS, Gandara DR, Hirsch FR, Redman MW, LeBlanc M, Mack PC et al. Lung master protocol (Lung-MAP)-a biomarker-driven protocol for accelerating development of therapies for squamous cell lung cancer: SWOG S1400. Clin Cancer Res 2015; 21: 1514–1524. ArticleCAS Google Scholar
Ebi H, Corcoran RB, Singh A, Chen Z, Song Y, Lifshits E et al. Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. J Clin Invest 2011; 121: 4311–4321. ArticleCAS Google Scholar
Ooi A, Inokuchi M, Harada S, Inazawa J, Tajiri R, Kitamura SS et al. Gene amplification of ESR1 in breast cancers—fact or fiction? A fluorescence in situ hybridization and multiplex ligation-dependent probe amplification study. J Pathol 2012; 227: 8–16. ArticleCAS Google Scholar
Niederst MJ, Sequist LV, Poirier JT, Mermel CH, Lockerman EL, Garcia AR et al. RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. Nat Commun 2015; 6: 6377. ArticleCAS Google Scholar
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2012; 2: 401–404. Article Google Scholar
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 2013; 6: pl1. Article Google Scholar