Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice (original) (raw)

Data availability

Metagenomic sequencing data for donors and mice samples have been deposited in the CNGB Nucleotide Sequence Archive (CNSA) database under accession identification CNP0000119.

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Acknowledgements

This study was supported by the Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University (No. XJTU1AF-CRF-2016-005), Shenzhen Municipal Government of China (Nos. JCYJ20170817145523036 and DRC-SZ [2015]162), Innovation Team Project of Natural Science Fund of Shaanxi Province (2017KCT-20), and Key Program of Natural Science Fund of Shaanxi Province (2018ZDXD-SF-036).

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Author notes

  1. These authors contributed equally: Feng Zhu, Ruijin Guo, Wei Wang, Yanmei Ju, Qi Wang

Authors and Affiliations

  1. Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an, 710061, China
    Feng Zhu
  2. BGI-Shenzhen, 518083, Shenzhen, China
    Ruijin Guo, Yanmei Ju, Qi Wang, Qiang Sun, Zhuye Jie, Liang Xiao, Tao Zhang, Xun Xu, Huanming Yang, Jian Wang, Lise Madsen, Susanne Brix, Karsten Kristiansen & Huijue Jia
  3. China National Genebank, 518120, Shenzhen, China
    Ruijin Guo, Yanmei Ju, Zhuye Jie, Liang Xiao, Tao Zhang, Xun Xu & Huijue Jia
  4. Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, 518083, Shenzhen, China
    Ruijin Guo, Yanmei Ju, Zhuye Jie & Huijue Jia
  5. Macau University of Science and Technology, Taipa, 999078, Macau, China
    Ruijin Guo & Huijue Jia
  6. Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, 710061, Xi’an, China
    Wei Wang, Qingyan Ma, Yajuan Fan, Zai Yang, Binbin Zhao, Lin Yang, Liyang Guo, Xiaoyan He, Yunchun Chen, Ce Chen, Chengge Gao & Xiancang Ma
  7. Center for Brain Science, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, 710061, Xi’an, China
    Wei Wang, Qingyan Ma, Yajuan Fan, Zai Yang, Binbin Zhao, Lin Yang, Liyang Guo, Xiaoyan He, Yunchun Chen, Ce Chen, Chengge Gao & Xiancang Ma
  8. Clinical Research Center for Psychiatric Medicine of Shaanxi Province, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, 710061, Xi’an, China
    Wei Wang, Qingyan Ma, Yajuan Fan, Zai Yang, Binbin Zhao, Lin Yang, Liyang Guo, Xiaoyan He, Yunchun Chen, Ce Chen, Chengge Gao & Xiancang Ma
  9. BGI Education Center, University of Chinese Academy of Sciences, 518083, Shenzhen, China
    Yanmei Ju & Qi Wang
  10. Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada
    Qiang Sun
  11. Department of Statistics and Probability, Michigan State University, East Lansing, MI, USA
    Yuying Xie
  12. Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI-Shenzhen, 518083, Shenzhen, China
    Liang Xiao
  13. Shenzhen Key Laboratory of Cognition and Gene Research, BGI-Shenzhen, 518083, Shenzhen, China
    Tao Zhang
  14. Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK
    Bing Liu
  15. James D. Watson Institute of Genome Sciences, 310058, Hangzhou, China
    Huanming Yang & Jian Wang
  16. School of Forensic Medicine, Xi’an Jiaotong University, 76 Yanta West Road, 710061, Xi’an, China
    Yonghui Dang
  17. Institute of Marine Research (IMR), P.O. Box 7800, 5020, Bergen, Norway
    Lise Madsen
  18. Department of Biology, University of Copenhagen, Universitetsparken 13, Copenhagen, 2100, Denmark
    Lise Madsen
  19. Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark
    Lise Madsen & Karsten Kristiansen
  20. Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs, Lyngby, Denmark
    Susanne Brix

Authors

  1. Feng Zhu
  2. Ruijin Guo
  3. Wei Wang
  4. Yanmei Ju
  5. Qi Wang
  6. Qingyan Ma
  7. Qiang Sun
  8. Yajuan Fan
  9. Yuying Xie
  10. Zai Yang
  11. Zhuye Jie
  12. Binbin Zhao
  13. Liang Xiao
  14. Lin Yang
  15. Tao Zhang
  16. Bing Liu
  17. Liyang Guo
  18. Xiaoyan He
  19. Yunchun Chen
  20. Ce Chen
  21. Chengge Gao
  22. Xun Xu
  23. Huanming Yang
  24. Jian Wang
  25. Yonghui Dang
  26. Lise Madsen
  27. Susanne Brix
  28. Karsten Kristiansen
  29. Huijue Jia
  30. Xiancang Ma

Contributions

XM, HJ, RG, FZ and ZJ conceived the study. FZ, ZY, FZ, LY, BZ, and QM did mice experiment. WW, QM, YF, LG, YD, YC, CC, CG, and XM recruited volunteers and collected samples for the study. WW, QM. YF, ZY, LY, and FZ collected faeces. YJ, QW, RG, QS, and YX performed the analyses. ZY, FZ, LY, BZ, and QM performed the mice experiment. KK, SB, and LM advised on the mice experiments. FZ, HJ, RG, YJ, and QW interpreted the results and wrote the paper. All authors contributed to revision of the paper.

Corresponding authors

Correspondence toKarsten Kristiansen, Huijue Jia or Xiancang Ma.

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Zhu, F., Guo, R., Wang, W. et al. Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice.Mol Psychiatry 25, 2905–2918 (2020). https://doi.org/10.1038/s41380-019-0475-4

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