Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors (original) (raw)
Feinberg A, Vogelstein B . Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983; 301: 89–92. ArticleCASPubMed Google Scholar
Robertson K . DNA methylation, methyltransferases, and cancer. Oncogene 2001; 20, 3139–3155. ArticleCASPubMed Google Scholar
Ohlsson R et al. IGF2 is parentally imprinted during human embryogenesis and in the Beckwith–Weidemann syndrome. Nature Genet 1993; 4: 94–97. ArticleCASPubMed Google Scholar
Giannoukakis N, Deal C, Paquette J, Goodyer C, Polychronakos C . Parental genomic imprinting of the human IGF2 gene. Nature Genet 1993; 4: 98–101. ArticleCASPubMed Google Scholar
Zhang Y, Tycko B . Monoallelic expression of the human H19 gene. Nature Genet 1992; 1: 40–44. ArticleCASPubMed Google Scholar
Ogawa O et al. Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour. Nature 1993; 362: 749–751. ArticleCASPubMed Google Scholar
Weksberg R, Shen DR, Fei YL, Song QL, Squire J . Disruption of insulin-like growth factor 2 imprinting in Beckwith–Wiedemann syndrome. Nature Genet 1993; 5: 143–150. ArticleCASPubMed Google Scholar
Sun FL, Dean WL, Kelsey G, Allen ND, Reik W . Transactivation of Igf2 in a mouse model of Beckwith–Wiedemann syndrome. Nature 1997; 389: 809–815. ArticleCASPubMed Google Scholar
Pabo CO, Peisach E, Grant RA . Design and selection of novel Cys2His2 zinc finger proteins. Annu Rev Biochem 2001; 70: 313–340. ArticleCASPubMed Google Scholar
Liu Q, Xia Z, Case CC . Validated zinc finger protein designs for all 16 GNN DNA triplet targets. J Biol Chem 2002; 277: 3850–3856. ArticleCASPubMed Google Scholar
Dreier B, Beerli RR, Segal DJ, Flippin JD, Barbas CF 3rd . Development of zinc finger domains for recognition of the 5′-ANN-3′ family of DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem 2001; 276: 29466–29478. ArticleCASPubMed Google Scholar
Segal DJ, Dreier B, Beerli RR, Barbas CF 3rd . Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences. Proc Natl Acad Sci USA 1999; 96: 2758–2763. ArticleCASPubMedPubMed Central Google Scholar
Rebar EJ, Greisman HA, Pabo CO . Phage display methods for selecting zinc finger proteins with novel DNA-binding specificities. Methods Enzymol 1996; 267: 129–149. ArticleCASPubMed Google Scholar
Rebar EJ, Pabo CO . Zinc finger phage: affinity selection of fingers with new DNA-binding specificities. Science 1994; 263: 671–673. ArticleCASPubMed Google Scholar
Beerli RR, Segal DJ, Dreier B, Barbas CF 3rd . Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc Natl Acad Sci USA 1998; 95: 14628–14633. ArticleCASPubMedPubMed Central Google Scholar
Zhang L et al. Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene. J Biol Chem 2000; 275: 33850–33860. ArticleCASPubMed Google Scholar
Liu PQ et al. Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem 2001; 276: 11323–11334. ArticleCASPubMed Google Scholar
Beerli RR, Dreier B, Barbas CF 3rd . Positive and negative regulation of endogenous genes by designed transcription factors. Proc Natl Acad Sci USA 2000; 97: 1495–1500. ArticleCASPubMedPubMed Central Google Scholar
Bartsevich VV, Juliano RL . Regulation of the MDR1 gene by transcriptional repressors selected using peptide combinatorial libraries. Mol Pharmacol 2000; 58: 1–10. ArticleCASPubMed Google Scholar
Xu D, Ye D, Fisher M, Juliano RL . Selective inhibition of P-glycoprotein expression in multidrug-resistant tumor cells by a designed transcriptional regulator. J Pharmacol Exp Ther 2002; 302: 963–971. ArticleCASPubMed Google Scholar
Ren D, Collingwood TN, Rebar EJ, Wolffe AP, Camp HS . PPAR gamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis. Genes Dev 2002; 16: 27–32. ArticleCASPubMedPubMed Central Google Scholar
Ekström TJ, Cui H, Li X, Ohlsson R . Promoter-specific IGF2 imprinting status and its plasticity during human liver development. Development 1995; 121: 309–316. PubMed Google Scholar
van Dijk MA, van Schaik FM, Bootsma HJ, Holthuizen JS . Initial charaterization of the four promoters of the human IGF II gene. Mol Cell Endocrinol 1991; 81: 81–94. ArticleCASPubMed Google Scholar
Vu TH, Hoffman AR . Promoter-specific imprinting of the human insulin-like growth factor-II gene. Nature 1994; 371: 714–717. ArticleCASPubMed Google Scholar
Hao Y, Crenshaw T, Moulton T, Newcomb E, Tycko B . Tumour-suppressor activity of H19 RNA. Nature 1993; 365: 764–767. ArticleCASPubMed Google Scholar
Cui H et al. Inactivation of H19, an imprinted and putative tumor repressor gene, is a preneoplastic event during Wilms' tumorigenesis. Cancer Res 1997; 57: 4469–4473. CASPubMed Google Scholar
Sap J, Munoz A, Schmitt J, Stunnenberg H, Vennstrom B . Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product. Nature 1989; 340: 242–244. ArticleCASPubMed Google Scholar
Damm K, Thompson CC, Evans RM . Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature 1989; 339: 593–597. ArticleCASPubMed Google Scholar
Zenke M, Munoz A, Sap J, Vennstrom B, Beug H . v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Cell 1990; 61: 1035–1049. ArticleCASPubMed Google Scholar
Yao F, Schaffer PA . An activity specified by the osteosarcoma line U2OS can substitute functionally for ICP0, a major regulatory protein of herpes simplex virus type 1. J Virol 1995; 69: 6249–6258. CASPubMedPubMed Central Google Scholar
Koziczak M, Muller H, Helin K, Nagamine Y . E2F1-mediated transcriptional inhibition of the plasminogen activator inhibitor type 1 gene. Eur J Biochem 2001; 268: 4969–4978. ArticleCASPubMed Google Scholar
Kiess W, Paquette J, Koepf G, Wolf E, Deal C . Proinsulin-like growth factor-II overexpression does not alter monoallelic H19 gene expression in transfected human embryonic kidney fibroblasts. Biochem Biophys Res Commun 1999; 255: 226–230. ArticleCASPubMed Google Scholar
Kugoh H et al. Mouse A9 cells containing single human chromosomes for analysis of genomic imprinting. DNA Res 1999; 6: 165–172. ArticleCASPubMed Google Scholar
Inoue J et al. Construction of 700 human/mouse A9 monochromosomal hybrids and analysis of imprinted genes on human chromosome 6. J Hum Genet 2001; 46: 137–145. ArticleCASPubMed Google Scholar
Thorvaldsen JL, Duran KL, Bartolomei MS . Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2. Genes Dev 1998; 12: 3693–3702. ArticleCASPubMedPubMed Central Google Scholar
Ohlsson R, Renkawitz R, Lobanenkov V . CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. Trends Genet 2001; 17: 520–527. ArticleCASPubMed Google Scholar
Kanduri C et al. Functional interaction of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr Biol 2000; 10: 853–856. ArticleCASPubMed Google Scholar
Bell AC, Felsenfeld G . Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature 2000; 405: 482–485. ArticleCASPubMed Google Scholar
Hark AT et al. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 2000; 405: 486–489. ArticleCASPubMed Google Scholar
Svensson K et al. The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns. Development 1998; 125: 61–69. CASPubMed Google Scholar
Drewell RA, Goddard CJ, Thomas JO, Surani MA . Methylation-dependent silencing at the H19 imprinting control region by MeCP2. Nucleic Acids Res 2002; 30: 1139–1144. ArticleCASPubMedPubMed Central Google Scholar
Jouvenot Y, Poirier F, Jami J, Paldi A . Biallelic transcription of Igf2 and H19 in individual cells suggests a post-transcriptional contribution to genomic imprinting. Curr Biol 1999; 9: 1199–1202. ArticleCASPubMed Google Scholar
Wu H, Yang WP, Barbas CF 3rd. Building zinc fingers by selection: toward a therapeutic application. Proc Natl Acad Sci USA 1995; 92: 344–348. ArticleCASPubMedPubMed Central Google Scholar
Kim JS, Pabo CO . Transcriptional repression by zinc finger peptides. Exploring the potential for applications in gene therapy. J Biol Chem 1997; 272: 29795–29800. ArticleCASPubMed Google Scholar
Reik A, Gregory PD, Urnov FD . Biotechnologies and therapeutics: chromatin as a target. Curr Opin Genet Dev 2002; 12: 233–242. ArticleCASPubMed Google Scholar
Kim JS, Pabo CO . Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants. Proc Natl Acad Sci USA 1998; 95: 2812–2817. ArticleCASPubMedPubMed Central Google Scholar
Sadowski I, Ma J, Triezenberg S, Ptashne M . GAL4-VP16 is an unusually potent transcriptional activator. Nature 1988; 335: 563–564. ArticleCASPubMed Google Scholar
Ruben SM et al. Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B. Science 1991; 251: 1490–1493. ArticleCASPubMed Google Scholar
Sap J et al. The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature 1986; 324: 635–640. ArticleCASPubMed Google Scholar
Franklin G et al. The human PDGF-B gene is regulated by cell type-specific activator and suppressor elements in the first intron. EMBO J 1991; 10: 1365–1373. ArticleCASPubMedPubMed Central Google Scholar