Temporal, spatial, and cell type–specific control of Cre-mediated DNA recombination in transgenic mice (original) (raw)

• Porter, A. Controlling your losses: conditional gene silencing in mammals. Trends Genet. 14, 73–79 (1998).
  Article CAS Google Scholar
• Sauer, B. Inducible gene targeting in mice using the Cre/lox system. Methods 14, 381–392 ( 1998).
  Article CAS Google Scholar
• Gu, H., Zou, Y.R. & Rajewsky, K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, 1155–1164 (1993).
  Article CAS Google Scholar
• Lakso, M. et al. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl. Acad. Sci. USA 89, 6232 –6236 (1992).
  Article CAS Google Scholar
• O'Gorman, S., Fox, D.T. & Wahl, G.M. Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science 251, 1351–1355 (1991).
  Article CAS Google Scholar
• Dymecki, S.M. Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc. Natl. Acad. Sci. USA 93, 6191–6196 (1996).
  Article CAS Google Scholar
• Buchholz, F., Ringrose, L., Angrand, P.O., Rossi, F. & Stewart, A.F. Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res. 24, 4256– 4262 (1996).
  Article CAS Google Scholar
• Buchholz, F., Angrand, P.O. & Stewart, A.F. Improved properties of FLP recombinase evolved by cycling mutagenesis. Nat. Biotechnol. 16, 657–662 (1998).
  Article CAS Google Scholar
• Kühn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427– 1429 (1995).
  Article Google Scholar
• No, D., Yao, T.P. & Evans, R.M. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl. Acad. Sci. USA 93, 3346–3351 (1996).
  Article CAS Google Scholar
• Schwenk, F., Kühn, R., Angrand, P.O., Rajewsky, K. & Stewart, A.F. Temporally and spatially regulated somatic mutagenesis in mice. Nucleic Acids Res. 26, 1427–1432 (1998).
  Article CAS Google Scholar
• Danielian, P.S., Muccino, D., Rowitch, D.H., Michael, S.K. & McMahon, A.P. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr. Biol. 8, 1323–1326 (1998).
  Article CAS Google Scholar
• Zhang, Y. et al. Inducible site-directed recombination in mouse embryonic stem cells. Nucleic Acids Res. 24, 543–548 (1996).
  Article CAS Google Scholar
• Brocard, J. et al. Spatio-temporally controlled site-specific somatic mutagenesis in the mouse. Proc. Natl. Acad. Sci. USA 94, 14559–14563 (1997).
  Article CAS Google Scholar
• Kellendonk, C. et al. Regulation of Cre recombinase activity by the synthetic steroid RU 486. Nucleic Acids Res. 24, 1404– 1411 (1996).
  Article CAS Google Scholar
• Kellendonk, C. et al. Inducible site-specific recombination in the brain. J. Mol. Biol. 285, 175–182 (1999).
  Article CAS Google Scholar
• Shibata, H. et al. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 278, 120– 123 (1997).
  Article CAS Google Scholar
• Akagi, K. et al. Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res. 25, 1766–1773 (1997).
  Article CAS Google Scholar
• Lee, Y.H., Sauer, B., Johnson, P.F. & Gonzalez, F.J. Disruption of the c/ebp alpha gene in adult mouse liver. Mol. Cell. Biol. 17, 6014–6022 (1997).
  Article CAS Google Scholar
• Wakita, T. et al. Efficient conditional transgene expression in hepatitis C virus cDNA transgenic mice mediated by the Cre/loxP system. J. Biol. Chem. 273, 9001–9006 (1998).
  Article CAS Google Scholar
• Wang, Y., Krushel, L.A. & Edelman, G.M. Targeted DNA recombination in vivo using an adenovirus carrying the Cre recombinase gene. Proc. Natl. Acad. Sci. USA 93, 3932–3936 (1996).
  Article CAS Google Scholar
• Burcin, M.M., Schiedner, G., Kochanek, S., Tsai, S.Y. & O'Malley, B.W. Adenovirus-mediated regulable target gene expression in vivo. Proc. Natl. Acad. Sci. USA 96, 355–360 (1999).
  Article CAS Google Scholar
• Kafri, T. et al. Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy. Proc. Natl. Acad. Sci. USA 95, 11377– 11382 (1998).
  Article CAS Google Scholar
• Anderson, W.F. Human gene therapy. Nature 392, 25– 30 (1998).
  Article CAS Google Scholar
• Morsy, M.A. et al. An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene. Proc. Natl. Acad. Sci. USA 95, 7866– 7871 (1998).
  Article CAS Google Scholar
• St-Onge, L., Furth, P.A. & Gruss, P. Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter. Nucleic Acids Res. 24, 3875–3877 (1996).
  Article CAS Google Scholar
• Gossen, M. & Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89, 5547–5551 (1992).
  Article CAS Google Scholar
• Furth, P.A. et al. Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc. Natl. Acad. Sci. USA 91, 9302–9306 (1994).
  Article CAS Google Scholar
• Passman, R.S. & Fishman, G.I. Regulated expression of foreign genes in vivo after germline transfer. J. Clin. Invest. 94, 2421–2425 (1994).
  Article CAS Google Scholar
• Gossen, M. et al. Transcriptional activation by tetracyclines in mammalian cells. Science 268, 1766–1769 (1995).
  Article CAS Google Scholar
• Kistner, A. et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc. Natl. Acad. Sci. USA 93, 10933–10938 (1996).
  Article CAS Google Scholar
• Böcker, R., Warnke, L. & Estler, C.J. Blood and organ concentrations of tetracycline and doxycycline in female mice. Comparison to males. Arzneimittelforschung 34, 446–448 (1984).
  PubMed Google Scholar
• Wivagg, R.T., Jaffe, J.M. & Colaizzi, J.L. Influence of pH and route of injection on acute toxicity of tetracycline in mice. J. Pharm. Sci. 65, 916–918 (1976).
  Article CAS Google Scholar
• Blau, H.M. & Rossi, F.M.V. Tet B or not tet B: advances in tetracycline-inducible gene expression. Proc. Natl. Acad. Sci. USA 96, 797–799 (1999).
  Article CAS Google Scholar
• Schultze, N., Burki, Y., Lang, Y., Certa, U. & Bluethmann, H. Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice. Nat. Biotechnol. 14, 499–503 (1996).
  Article CAS Google Scholar
• Chrast-Balz, J. & Hooft van Huijsduijnen, R. Bi-directional gene switching with the tetracycline repressor and a novel tetracycline antagonist. Nucleic Acids Res. 24, 2900–2904 (1996).
  Article CAS Google Scholar
• Hofmann, A., Nolan, G.P. & Blau, H.M. Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette. Proc. Natl. Acad. Sci. USA 93, 5185–5190 (1996).
  Article CAS Google Scholar
• A-Mohammadi, S. & Hawkins, R.E. Efficient transgene regulation from a single tetracycline-controlled positive feedback regulatory system. Gene Ther. 5, 76– 84 (1998).
  Article CAS Google Scholar
• Harding, T.C., Geddes, B.J., Murphy, D., Knight, D. & Uney, J.B. Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system. Nat. Biotechnol. 16 , 553–555 (1998).
  Article CAS Google Scholar
• Hong, F.D. et al. Structure of the human retinoblastoma gene. Proc. Natl. Acad. Sci. USA 86, 5502–5506 (1989).
  Article CAS Google Scholar
• Tsien, J.Z. et al. Subregion- and cell type-restricted gene knockout in mouse brain. Cell 87, 1317–1326 (1996).
  Article CAS Google Scholar
• Zinyk, D.L., Mercer, E.H., Harris, E., Anderson, D.J. & Joyner, A.L. Fate mapping of the mouse midbrain-hindbrain constriction using a site- specific recombination system. Curr. Biol. 8, 665–668 (1998).
  Article CAS Google Scholar
• Baron, U. et al. Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes. Proc. Natl. Acad. Sci. USA 96, 1013–1018 (1999).
  Article CAS Google Scholar
• Baron, U., Gossen, M. & Bujard, H. Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res. 25, 2723–2729 (1997).
  Article CAS Google Scholar
• Al-Ali, W., Bissada, N.F. & Greenwell, H. The effect of local doxycycline with and without tricalcium phosphate on the regenerative healing potential of periodontal osseous defects in dogs. J. Periodontol. 60, 582– 590 (1989).
  Article CAS Google Scholar
• Webster, G.F., Toso, S.M. & Hegemann, L. Inhibition of a model of in vitro granuloma formation by tetracyclines and ciprofloxacin. Involvement of protein kinase C. Arch. Dermatol. 130, 748–752 (1994).
  Article CAS Google Scholar
• Larsen, T. In vitro release of doxycycline from bioabsorbable materials and acrylic strips. J. Periodontol. 61, 30– 34 (1990).
  Article CAS Google Scholar
• Golub, L.M., Ciancio, S., Ramamamurthy, N.S., Leung, M. & McNamara, T.F. Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans. J. Periodontal Res. 25, 321–330 (1990).
  Article CAS Google Scholar
• Bignon, Y.J. et al. Expression of a retinoblastoma transgene results in dwarf mice. Genes Dev. 7, 1654–1662 (1993).
  Article CAS Google Scholar
• Chang, C.Y., Riley, D.J., Lee, E.Y. & Lee, W.H. Quantitative effects of the retinoblastoma gene on mouse development and tissue-specific tumorigenesis. Cell Growth Differ. 4, 1057– 1064 (1993).
  CAS PubMed Google Scholar
• Lee, W.H. et al. Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science 235, 1394–1399 (1987).
  Article CAS Google Scholar
• Friend, S.H. et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323, 643–646 (1986).
  Article CAS Google Scholar
• Nikitin, A.Y., Juárez-Pérez, M.I., Li, S., Huang, L. & Lee, W.-H. RB-mediated suppression of multiple neuroendocrine neoplasia and lung metastases in Rb+/– mice. Proc. Natl. Acad. Sci. USA 96, 3916 –3921 (1999).
  Article CAS Google Scholar
• Cordon-Cardo, C. & Richon, V.M. Expression of the retinoblastoma protein is regulated in normal human tissues. Am. J. Pathol. 144, 500–510 (1994).
  CAS PubMed PubMed Central Google Scholar
• Szekely, L. et al. Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses. Cell Growth Differ. 3, 149–156 (1992).
  CAS PubMed Google Scholar
• Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70–71 (1999).
  Article CAS Google Scholar
• Wagner, K.U. et al. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. 25, 4323–4330 (1997).
  Article CAS Google Scholar
• Bayna, E.M. & Rosen, J.M. Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice. Nucleic Acids Res. 18, 2977–2985 (1990).
  Article CAS Google Scholar
• Pittius, C.W. et al. A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice. Proc. Natl. Acad. Sci. USA 85, 5874– 5878 (1988).
  Article CAS Google Scholar
• Gu, H., Marth, J.D., Orban, P.C., Mossmann, H. & Rajewsky, K. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265, 103–106 (1994).
  Article CAS Google Scholar
• Lakso, M. et al. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc. Natl. Acad. Sci. USA 93, 5860– 5865 (1996).
  Article CAS Google Scholar
• Bonnerot, C. & Nicolas, J.F. Application of LacZ gene fusions to postimplantation development. Methods Enzymol. 225 , 451–469 (1993).
  Article CAS Google Scholar
• Nikitin, A.Y. & Lee, W.H. Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/– mice. Genes Dev. 10, 1870–1879 (1996).
  Article CAS Google Scholar
• Nikitin, A.Y., Rajewsky, M.F. & Pozharisski, K.M. Development of malignant fibrous histiocytoma induced by 7,12-dimethylbenz[a]anthracene in the rat: characterization of early atypical cells. Virchows Arch. B 64, 151– 159 (1993).
  Article CAS Google Scholar