Gossen, M.et al. Transcriptional activation by tetracyclines in mammalian cells. Science268, 1766–1769 (1995). ArticleADSCAS Google Scholar
Fasano, O., Taparowsky, E., Fiddes, J., Wigler, M. & Goldfarb, M. Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells. J. Mol. Appl. Genet.2, 173–180 (1983). CASPubMed Google Scholar
Kistner, A.et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc. Natl Acad. Sci. USA93, 10933–10938 ( 1996). ArticleADSCAS Google Scholar
Chin, L.et al. Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev.11, 2822– 2834 (1997). ArticleCAS Google Scholar
Thomson, T. M.et al. Differentiation antigens of melanocytes and melanoma: analysis of melanosome and cell surface markers of human pigmented cells with monoclonal antibodies. J. Invest. Dermatol.90, 459 –466 (1988). ArticleCAS Google Scholar
Gause, P. R.et al. Chromosomal and genetic alterations of 7,12-dimethylbenz[a]anthracene-induced melanoma from TP-ras transgenic mice. Mol. Carcin.20, 78–87 (1997). ArticleCAS Google Scholar
Shirasawa, S., Furuse, M., Yokoyama, N. & Sasazuki, T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science260, 85–88 ( 1993). ArticleADSCAS Google Scholar
Doherty, P. C., Tripp, R. A. & Sixbey, J. W. Evasion of host immune responses by tumours and viruses. Ciba Found. Symp.187, 245– 256 (1994). CASPubMed Google Scholar
Bird, I. N., Spragg, J. H., Ager, A. & Matthews, N. Studies of lymphocyte transendothelial migration: analysis of migrated cell phenotypes with regard to CD31 (PECAM-1), CD45RA and CD45RO. Immunology80 , 553–560 (1993). CASPubMedPubMed Central Google Scholar
Traweek, S. T., Kandalaft, P. L., Mehta, P. & Battifora, H. The human hematopoietic progenitor cell antigen (CD34) in vascular neoplasia. Am. J. Clin. Pathol.96, 25– 31 (1991). ArticleCAS Google Scholar
Rak, J.et al. Oncogenes as inducers of tumor angiogenesis. Cancer Metastasis Rev.14, 263–277 ( 1995). ArticleCAS Google Scholar
Arbiser, J. L.et al . Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc. Natl Acad. Sci. USA94, 861–866 (1997). ArticleADSCAS Google Scholar
Okada, F.et al. Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells. Proc. Natl Acad. Sci. USA95, 3609– 3614 (1998). ArticleADSCAS Google Scholar
Shweiki, D., Itin, A., Soffer, D. & Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature359, 843–845 (1992). ArticleADSCAS Google Scholar
Mazure, N. M., Chen, E. Y., Yeh, P., Laderoute, K. R. & Giaccia, A. J. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res.56, 3436–3440 (1996). CASPubMed Google Scholar
Goldberg, M. A. & Schneider, T. J. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J. Biol. Chem.269, 4355–4359 (1994). CASPubMed Google Scholar
Mukhopadhyay, D.et al . Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature375, 577–581 (1995). ArticleADSCAS Google Scholar
Rak, J.et al. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res.55 , 4575–4580 (1995). CASPubMed Google Scholar
Grugel, S., Finkenzeller, G., Weindel, K., Barleon, B. & Marme, D. Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J. Biol. Chem.270, 25915–25919 (1995). ArticleCAS Google Scholar
Larcher, F.et al. Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels. Cancer Res.56, 5391–5396 ( 1996). CASPubMed Google Scholar
Ganss, R., Montoliu, L., Monaghan, A. P. & Schutz, G. Acell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice. EMBO J.13, 3083–3093 ( 1994). ArticleCAS Google Scholar
Valenzuela, D. M.et al. Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscule, at the neuromuscular junction, and after injury. Neuron15, 573– 584 (1995). ArticleCAS Google Scholar
Schreiber-Agus, N.et al. Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. Nature393, 483–487 (1998). ArticleADSCAS Google Scholar
Gavrieli, Y., Sherman, Y. & Ben-Sasson, S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol.119, 493–501 ( 1992). ArticleCAS Google Scholar
Cheng, L., Fu, J., Tsukamoto, A. & Hawley, R. G. Use of green fluorescent protein variants to monitor gene transfer and expression in mammalian cells. Nature Biotech.14, 606– 609 (1996). ArticleCAS Google Scholar