Synaptic function modulated by changes in the ratio of synaptotagmin I and IV (original) (raw)

References

1. Littleton, J. T., Stern, M., Schulze, K., Perin, M. & Bellen, H. J. Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca2+-activated neurotransmitter release. Cell 74, 1125–1134 (1993).
   Article CAS PubMed Google Scholar
2. Littleton, J. T., Stern, M., Perin, M. & Bellen, H. J. Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants. Proc. Natl Acad. Sci. USA 91, 10888–10892 (1994).
   Article ADS CAS PubMed PubMed Central Google Scholar
3. Geppert, M. et al. Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell 79, 717–727 (1994).
   Article CAS PubMed Google Scholar
4. Chapman, E. & Davis, A. Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers. J. Biol. Chem. 273, 13995–14001 (1998).
   Article CAS PubMed Google Scholar
5. Vician, L. et al. Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain. Proc. Natl Acad. Sci. USA 92, 2164–2168 (1995).
   Article ADS CAS PubMed PubMed Central Google Scholar
6. Sudhof, T. & Rizo, J. Synaptotagmins: C2-domain proteins that regulate membrane traffic. Neuron 17, 379–388 (1996).
   Article CAS PubMed Google Scholar
7. Perin, M. S., Fried, V. A., Mignery, G. A., Jahn, R. & Südhof, T. C. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Nature 345, 260–263 (1990).
   Article ADS CAS PubMed Google Scholar
8. Brose, N., Petrenko, A. G., Sudhof, T. C. & Jahn, R. Synaptotagmin: a Ca2+ sensor on the synaptic vesicle surface. Science 256, 1021–1025 (1992).
   Article ADS CAS PubMed Google Scholar
9. Chapman, E. R., An, S., Edwardson, J. M. & Jahn, R. Anovel function for the second C2 domain of synaptotagmin: Ca2+-triggered dimerization. J. Biol. Chem. 271, 5844–5849 (1996).
   Article CAS PubMed Google Scholar
10. Chapman, E. R., Hanson, P. I., An, S. & Jahn, R. Ca2+ regulates the interaction between synaptotagmin and syntaxin 1. J. Biol. Chem. 270, 23667–23671 (1995).
    Article CAS PubMed Google Scholar
11. Schiavo, G., Stenbeck, G., Rothman, J. & Sollner, T. Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses. Proc. Natl Acad. Sci. USA 94, 997–1001 (1997).
    Article ADS CAS PubMed PubMed Central Google Scholar
12. Li, C. et al. Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins. Nature 375, 594–599 (1995).
    Article ADS CAS PubMed Google Scholar
13. Littleton, J. T. et al. Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly. Neuron 21, 401–413 (1998).
    Article CAS PubMed Google Scholar
14. Sutton, R., Davletov, B., Berghuis, A., Sudhof, T. & Sprang, S. Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold. Cell 80, 929–938 (1995).
    Article CAS PubMed Google Scholar
15. von Poser, C., Ichtchenko, K., Shao, X., Rizo, J. & Sudhof, T. The evolutionary pressure to inactivate: Asubclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding. J. Biol. Chem. 272, 14314–14319 (1997).
    Article CAS PubMed Google Scholar
16. Chapman, E., Desai, R., Davis, A. & Tornehl, C. Delination of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin. J. Biol. Chem. 273, 32966–32973 (1998).
    Article CAS PubMed Google Scholar
17. Osborne, S. L., Herreros, J., Bastiaens, P. I. & Schiavo, G. Calcium-dependent oligomerization of synaptotagmins I and II. J. Biol. Chem. 274, 59–66 (1999).
    Article CAS PubMed Google Scholar
18. van de Goor, J., Ramaswami, M. & Kelly, R. Redistribution of synaptic vesicles and their proteins intemperature-sensitive shibire(ts1) mutant Drosophila. Proc. Natl Acad. Sci. USA 92, 5739–5743 (1995).
    Article ADS CAS PubMed PubMed Central Google Scholar
19. Fukuda, M., Kojima, T., Aruga, J., Niinobe, M. & Mikoshiba, K. Functional diversity of C2 domains of synaptotagmin family. J. Biol. Chem. 270, 26523–26527 (1995).
    Article CAS PubMed Google Scholar
20. Ferguson, G. D., Thomas, D. M., Elferink, L. A. & Herschman, H. R. Synthesis degradation, and subcellular localization of synaptotagmin IV, a neuronal immediate early gene product. J. Neurochem. 72, 1821–1831 (1999).
    Article CAS PubMed Google Scholar

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