The origin of lymphoid stem cells studied in chick yolk sac–embryo chimaeras (original) (raw)

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Nature volume 272, pages 353–354 (1978)Cite this article

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Abstract

THE development of lymphoid organs in the chick embryo is dependent on colonisation by extrinsic stem cells1–6, some of which are present in the yolk sac blood islands, as Moore and Owen demonstrated by transplanting 7-d yolk sac cells into 14-d-old irradiated chicken embryos2. These authors demonstrated population of lymphoid organs by donor-derived cells, and suggested that all haemopoietic stem cells are formed in the early yolk sac3. This interpretation has been challenged7–11, particularly on the basis of results obtained in quail–chick chimaeric germs7. We present here further evidence, based on the use of chick–chick yolk sac–embryo chimaeras, that lymphoid stem cells in the chicken do not originate primarily in the yolk sac.

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Authors and Affiliations

1. Department of Medical Microbiology, Turku University, SF-20520, Turku, 52, Finland
   OLLI LASSILA, JUSSI ESKOLA & PAAVO TOIVANEN
2. Institut d'Embryologie du C.N.R.S. et du Collège de France, 94130, Nogent-sur-Marne, France
   CLAUDE MARTIN & FRANCOISE DIETERLEN-LIEVRE

Authors

1. OLLI LASSILA
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2. JUSSI ESKOLA
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3. PAAVO TOIVANEN
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4. CLAUDE MARTIN
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5. FRANCOISE DIETERLEN-LIEVRE
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LASSILA, O., ESKOLA, J., TOIVANEN, P. et al. The origin of lymphoid stem cells studied in chick yolk sac–embryo chimaeras.Nature 272, 353–354 (1978). https://doi.org/10.1038/272353a0

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• Received: 10 October 1977
• Accepted: 06 February 1978
• Published: 01 March 1978
• Issue Date: 23 March 1978
• DOI: https://doi.org/10.1038/272353a0

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