Evidence from in vitro studies that tolerance to self antigens is MHC-restricted (original) (raw)

Nature volume 308, pages 741–744 (1984)Cite this article

Abstract

Mature T cells respond to foreign antigens in the context of self major histocompatibility complex (MHC)-encoded products: T helper cells recognize antigen in the context of class II1,2 molecules, while cytotoxic T cells (CTL) recognize antigen plus class I molecules3–6. Recent evidence suggests that the MHC-restricted T cell is unable to recognize either the foreign antigen or the self-MHC product alone, but only a complex of the two7–9. Unresponsiveness to self antigens—self tolerance—implies the deletion or suppression of clones of T cells having reactivity to self antigens10,11. Here we demonstrate the presence in normal mice of T cells which recognize self antigens together with allogeneic MHC products. This finding suggests the MHC restriction of T-cell recognition during the entire process of T-cell ontogeny, that is, MHC restriction of self tolerance.

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References

  1. Katz, D. H., Hamaoka, T. & Benecerraf, B. J. exp. Med. 137, 1405–1418 (1973).
    Article CAS Google Scholar
  2. Rosenthal, A. J. & Shevach, E. J. exp. Med. 138, 1194–1418 (1973).
    Article CAS Google Scholar
  3. Shearer, G. M. Eur. J. Immun. 4, 527–533 (1974).
    Article CAS Google Scholar
  4. Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).
    Article CAS ADS Google Scholar
  5. Bevan, M. J. Nature 256, 419–421 (1975).
    Article CAS ADS Google Scholar
  6. Gordon, R. D., Simpson, E. & Samuelson, L. E. J. exp. Med. 142, 1108–1120 (1975).
    Article CAS Google Scholar
  7. Kappler, J. W. et al. J. exp. Med. 153, 1198–1214 (1981).
    Article CAS Google Scholar
  8. Hunig, T. & Bevan, M. J. Nature 294, 460–462 (1981).
    Article CAS ADS Google Scholar
  9. Heber-Katz, E. et al. J. exp. Med. 155, 1086–1099 (1982).
    Article CAS Google Scholar
  10. Nossal, G. J. V. & Pike, B. L. Proc. natn. Acad. Sci. U.S.A. 78, 3844–3847 (1981).
    Article CAS ADS Google Scholar
  11. Dorsch, S. & Roser, B. J. exp. Med. 145, 1144–1157 (1977).
    Article CAS Google Scholar
  12. Zoschke, D. C. & Bach, F. H. Science 170, 1404–1406 (1970).
    Article CAS ADS Google Scholar
  13. Ishii, N. et al. J. exp. Med. 154, 978–982 (1981).
    Article CAS Google Scholar
  14. Janeway, C. A. et al. J. exp. Med. 147, 1065–1077 (1978).
    Article Google Scholar
  15. Wilson, D. B. et al. J. exp. Med. 146, 361–367 (1977).
    Article CAS Google Scholar
  16. Forman, J. & Streilein, J. W. J. exp. Med. 150, 1001–1007 (1979).
    Article CAS Google Scholar
  17. Stockinger, H. et al. J. exp. Med. 153, 1629–1639 (1981).
    Article CAS Google Scholar
  18. Teh, H.-S., Bennink, J. & Von Boehmer, H. Eur. J. Immun. 12, 887–892 (1982).
    Article CAS Google Scholar
  19. Maryanski, J. L., Cerottini, J.-C. & Brunner, K. T. J. Immun. 124, 839–845 (1980).
    CAS PubMed Google Scholar
  20. Lindahl, K. Immunogenetics 8, 71–76 (1979).
    Article Google Scholar
  21. Rammensee, H.-G. & Klein, J. Immunogenetics 17, 637–647 (1983).
    Article CAS Google Scholar
  22. Fischer Lindahl, K., Hausmann, B. & Chapman, V. M. Nature 36, 383–385 (1983).
    Article Google Scholar
  23. Groves, E. S. & Singer, A. J. exp. Med. 158, 1483–1497 (1983).
    Article CAS Google Scholar
  24. Dos Reis, G. A. & Shevach, E. M. J. exp. Med. 157, 1287–1299 (1983).
    Article CAS Google Scholar
  25. Schwartz, R. H. Scand. J. Immun. 7, 3–10 (1978).
    Article CAS Google Scholar
  26. Matzinger, P. Nature 292, 497–501 (1981).
    Article CAS ADS Google Scholar
  27. Ishii, N., Nagy, Z. A. & Klein, J. Nature 295, 531–533 (1982).
    Article CAS ADS Google Scholar
  28. Fink, P., Weissman, I. L. & Bevan, M. J. J. exp. Med. 157, 141–154 (1983).
    Article CAS Google Scholar
  29. Miller, R. G. Nature 287, 544–546 (1980).
    Article CAS ADS Google Scholar
  30. Rammensee, H.-G., Nagy, Z. & Klein, J. Eur. J. Immun. 12, 930–934 (1982).
    Article CAS Google Scholar
  31. Rammensee, H.-G., Juretic, A., Nagy, Z. A. & Klein, J. J. Immun. 132, 668–672 (1984).
    CAS PubMed Google Scholar
  32. Muraoka, S. & Miller, R. G. J. Immun. 131, 45–49 (1983).
    CAS PubMed Google Scholar

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Authors and Affiliations

  1. Department of Immunology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA
    Hans-Georg Rammensee & Michael J. Bevan

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  1. Hans-Georg Rammensee
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  2. Michael J. Bevan
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Rammensee, HG., Bevan, M. Evidence from in vitro studies that tolerance to self antigens is MHC-restricted.Nature 308, 741–744 (1984). https://doi.org/10.1038/308741a0

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