Evidence from in vitro studies that tolerance to self antigens is MHC-restricted (original) (raw)
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- Published: 19 April 1984
Nature volume 308, pages 741–744 (1984)Cite this article
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Abstract
Mature T cells respond to foreign antigens in the context of self major histocompatibility complex (MHC)-encoded products: T helper cells recognize antigen in the context of class II1,2 molecules, while cytotoxic T cells (CTL) recognize antigen plus class I molecules3–6. Recent evidence suggests that the MHC-restricted T cell is unable to recognize either the foreign antigen or the self-MHC product alone, but only a complex of the two7–9. Unresponsiveness to self antigens—self tolerance—implies the deletion or suppression of clones of T cells having reactivity to self antigens10,11. Here we demonstrate the presence in normal mice of T cells which recognize self antigens together with allogeneic MHC products. This finding suggests the MHC restriction of T-cell recognition during the entire process of T-cell ontogeny, that is, MHC restriction of self tolerance.
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Authors and Affiliations
- Department of Immunology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA
Hans-Georg Rammensee & Michael J. Bevan
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- Hans-Georg Rammensee
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Rammensee, HG., Bevan, M. Evidence from in vitro studies that tolerance to self antigens is MHC-restricted.Nature 308, 741–744 (1984). https://doi.org/10.1038/308741a0
- Received: 09 December 1983
- Accepted: 06 February 1984
- Issue Date: 19 April 1984
- DOI: https://doi.org/10.1038/308741a0
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