Identification of antigen receptor-associated structures on murine T cells (original) (raw)
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- Published: 07 March 1985
Nature volume 314, pages 107–109 (1985)Cite this article
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Abstract
The specific antigen receptor on human and murine T lymphocytes is a heterodimer of relative molecular mass (_M_r) 80,000–90,000 (80–90K) composed of two 40–50K disulphide-linked glycoprotein subunits1–8. Peptide map analysis of the _α_- and _β_-chains of receptor isolated from distinct tumour cell lines suggests the presence of both constant and variable regions2,9–12. Unlike the antigen receptor on B lymphocytes (that is, surface immunoglobulin), the human T-cell antigen receptor seems to be non-covalently associated with another invariant structure recognized by monoclonal antibodies to the cell-surface antigens T3 and Leu 4 (refs 4, 5, 9, 12). Meuer et al.5 have demonstrated co-modulation of the T3 structure and T-cell antigen receptor using anti-clonotypic and anti-T3 monoclonal antibodies. Furthermore, immunoprecipitation with anti-T3 weakly co-precipitates a small amount of the 80–90K heterodimer in certain conditions4,9,12. The murine homologue of the Leu 4/T3 structure has not been identified, although Gunter et al. have suggested that Thy-1 may be the counterpart of Leu 4/T3 (ref. 13). Here we describe a Leu 4/T3-like structure, distinct from Thy-1, associated with the T-cell receptor of a murine T-lymphoma cell line.
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Author notes
- James P. Allison
Present address: Department of Microbiology and Immunology, University of California, Berkeley, California, 94720, USA
Authors and Affiliations
- Science Park Research Division, University of Texas System Cancer Center, PO Box 389, Smithville, Texas, 78957, USA
James P. Allison - Becton Dickinson Monoclonal Center, Inc., 2375 Garcia Ave., Mountain View, California, 94043, USA
Lewis L. Lanier
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- James P. Allison
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Allison, J., Lanier, L. Identification of antigen receptor-associated structures on murine T cells.Nature 314, 107–109 (1985). https://doi.org/10.1038/314107a0
- Received: 16 July 1984
- Accepted: 05 December 1984
- Issue Date: 07 March 1985
- DOI: https://doi.org/10.1038/314107a0