Identification of antigen receptor-associated structures on murine T cells (original) (raw)

Nature volume 314, pages 107–109 (1985)Cite this article

Abstract

The specific antigen receptor on human and murine T lymphocytes is a heterodimer of relative molecular mass (_M_r) 80,000–90,000 (80–90K) composed of two 40–50K disulphide-linked glycoprotein subunits1–8. Peptide map analysis of the _α_- and _β_-chains of receptor isolated from distinct tumour cell lines suggests the presence of both constant and variable regions2,9–12. Unlike the antigen receptor on B lymphocytes (that is, surface immunoglobulin), the human T-cell antigen receptor seems to be non-covalently associated with another invariant structure recognized by monoclonal antibodies to the cell-surface antigens T3 and Leu 4 (refs 4, 5, 9, 12). Meuer et al.5 have demonstrated co-modulation of the T3 structure and T-cell antigen receptor using anti-clonotypic and anti-T3 monoclonal antibodies. Furthermore, immunoprecipitation with anti-T3 weakly co-precipitates a small amount of the 80–90K heterodimer in certain conditions4,9,12. The murine homologue of the Leu 4/T3 structure has not been identified, although Gunter et al. have suggested that Thy-1 may be the counterpart of Leu 4/T3 (ref. 13). Here we describe a Leu 4/T3-like structure, distinct from Thy-1, associated with the T-cell receptor of a murine T-lymphoma cell line.

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Author notes

  1. James P. Allison
    Present address: Department of Microbiology and Immunology, University of California, Berkeley, California, 94720, USA

Authors and Affiliations

  1. Science Park Research Division, University of Texas System Cancer Center, PO Box 389, Smithville, Texas, 78957, USA
    James P. Allison
  2. Becton Dickinson Monoclonal Center, Inc., 2375 Garcia Ave., Mountain View, California, 94043, USA
    Lewis L. Lanier

Authors

  1. James P. Allison
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  2. Lewis L. Lanier
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Allison, J., Lanier, L. Identification of antigen receptor-associated structures on murine T cells.Nature 314, 107–109 (1985). https://doi.org/10.1038/314107a0

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