Voltage-dependent calcium and potassium channels in retinal glial cells (original) (raw)
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- Published: 01 October 1985
Nature volume 317, pages 809–811 (1985)Cite this article
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Abstract
Glial cells, which outnumber neurones in the central nervous system, have traditionally been considered to be electrically inexcitable and to play only a passive role in the electrical activity of the brain1. Recent reports have demonstrated, however, that certain glial cells, when maintained in primary culture, possess voltage-dependent ion channels2–4. It remains to be demonstrated whether these channels are also present in glial cells in vivo. I show here that Müller cells, the principal glial cells of the vertebrate retina, can generate ‘Ca2+spikes’ in freshly excised slices of retinal tissue. In addition, voltage-clamp studies of enzymatically dissociated Müller cells demonstrate the presence of four types of voltage-dependent ion channels: a Ca2+ channel, a Ca2+-activated K+ channel, a fast-inactivating (type A) K+ channel and an inward-rectifying K+ channel. Currents generated by these voltage-dependent channels may enhance the ability of Müller cells to regulate extracellular K+ levels in the retina and may be involved in the generation of the electroretinogram.
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Authors and Affiliations
- Eye Research Institute of Retina Foundation, 20 Staniford Street, Boston, Massachusetts, 02114, USA
Eric A. Newman
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- Eric A. Newman
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Newman, E. Voltage-dependent calcium and potassium channels in retinal glial cells.Nature 317, 809–811 (1985). https://doi.org/10.1038/317809a0
- Received: 02 May 1985
- Accepted: 21 August 1985
- Published: 01 October 1985
- Issue Date: 31 October 1985
- DOI: https://doi.org/10.1038/317809a0