Regulation of E2F transcription by cyclin E–Cdk2 kinase mediated through p300/CBP co-activators (original) (raw)

References

  1. Slansky, J. E. & Farnham, P. J. Introduction to the E2F family: protein structure and gene regulation. Curr. Top. Microbiol. Immunol. 208, 1–30 ( 1996).
    CAS PubMed Google Scholar
  2. Dyson, N. The regulation of E2F by pRb-family proteins. Genes Dev. 12, 2245–2262 (1998).
    Article CAS Google Scholar
  3. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell 81, 323–330 (1995).
    Article CAS Google Scholar
  4. Lam, E. W. F. & La Thangue, N. B. DP and E2F proteins: co-ordinating transcription with cell cycle progression. Curr. Opin. Cell. Biol. 6, 859–866 ( 1994).
    Article CAS Google Scholar
  5. Sherr, C. J. Mammalian G1 kinases. Cell 73, 1059– 1065 (1993).
    Article CAS Google Scholar
  6. Hinds, P. W. et al. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70, 993 –1006 (1992).
    Article CAS Google Scholar
  7. Hatakeyama, M., Brill, J. A., Fink, G. R. & Weinberg, R. A. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev. 8, 1759– 1771 (1994)
    Article CAS Google Scholar
  8. Koff, A. et al. Formation and activation of a cyclin E-CDK2 complex during the G1 phase of the human cell cycle. Science 257, 1689–1694 (1992).
    Article CAS Google Scholar
  9. Ohtsubo, M., Theodoras, A. M., Schumacher, J., Roberts, J. M. & Pagano, M. Human cyclin E, a nuclear protein essential for the G1 to S phase transition. Mol. Cell Biol. 15, 2612–2624 (1995).
    Article CAS Google Scholar
  10. Lukas, J. et al. Cyclin E-induced S phase without activation of the Rb/E2F pathway . Genes Dev. 11, 1479–1492 (1997).
    Article CAS Google Scholar
  11. Lundberg, A. S. & Weinberg, R. A. Functional inactivation of the retinoblastoma protein reuqires sequential modification by at least two distinct cyclin-CDK complexes. Mol. Cell. Biol. 18, 753–761 ( 1998).
    Article CAS Google Scholar
  12. Sherr, C. J. Cancer cell cycles. Science 274, 1672– 1677 (1996).
    Article CAS Google Scholar
  13. Alevizopoulos, K., Vlach, J., Hennecke, S. & Amati, B. Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4aand of hypophosphorylated retinoblastoma family proteins. EMBO J. 16, 5322–5333 (1997).
    Article CAS Google Scholar
  14. Zhang, H. S., Postigo, A. A. & Dean, D. C. Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFβ, and contact inhibition. Cell 97, 53– 61 (1999).
    Article CAS Google Scholar
  15. Botz, J. et al. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell. Biol. 16, 3401–3409 (1996).
    Article CAS Google Scholar
  16. Helin, K. Regulation of cell proliferation by the E2F transcription factors. Curr. Opin. Genet. Dev. 8, 28–35 (1998).
    Article CAS Google Scholar
  17. Weintraub, S. J., Prater, C. A. & Dean, D. C. Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358, 259–261 (1992).
    Article CAS Google Scholar
  18. Luo, R. X., Postigo, A. A. & Dean, D. C. Rb interacts with histone deacetylase to repress transcription. Cell 92, 463– 473 (1998).
    Article CAS Google Scholar
  19. Beijersbergen, R. L. et al. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 8, 2680–2690 (1994).
    Article CAS Google Scholar
  20. Buck, V. et al. Molecular and functional characterisation of E2F-5, a new member of the E2F family. Oncogene 11, 31– 38 (1995).
    CAS PubMed Google Scholar
  21. Hijmans, E. M., Voorhoeve, P. M., Beijersbergen, R. L, van’t Veer, L. J. & Bernards, R. E2F-5, a new E2F family member that interacts with p130 in vivo. Mol. Cell. Biol. 15, 3082–3089 (1995).
    Article CAS Google Scholar
  22. Krek, W., Xu, G., & Livingston, D. M. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell 83, 1149–1158 (1995).
    Article CAS Google Scholar
  23. Marti, A., Wirbelauer, C., Scheffner, M. & Krek, W. Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nature Cell Biol. 1, 14–19 (1999 ).
    Article CAS Google Scholar
  24. Peeper, D. S. et al. Phosphorylation of a specific cdk site in E2F-1 affects its electrophoretic mobility and promotes pRB-binding in vitro. Oncogene 10, 39–48 ( 1994).
    Google Scholar
  25. Kitagawa, M. et al. Phosphorylation of E2F-1 by cyclin A-cdk2. Oncogene 10, 229–236 ( 1995).
    CAS PubMed Google Scholar
  26. Shikama, N., Lyon, J. & La Thangue, N. B. The p300/CBP family: integrating signals with transcription factors and chromatin. Trends Cell Biol. 7, 230–236 (1997).
    Article CAS Google Scholar
  27. Yang, X-Y., Ogryzko, V. V., Nishikawa, J-I., Howard, B. H. & Nakatani, Y. A p300/CBP-associated factor that competes with the adenovirus oncoprotein E1A. Nature 382, 319– 324 (1996).
    Article CAS Google Scholar
  28. Chen, H. et al. Nuclear receptor co-activator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90, 569–580 ( 1997).
    Article CAS Google Scholar
  29. Torchia, J. et al. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387, 677–684 (1997).
  30. Bannister, A. J. & Kouzarides, T. The CBP co-activator is a histone acetyltransferase. Nature 384, 641–643 (1996).
  31. Ogryzko, V. V., Schitz, R. L., Russanova, V., Howard, B. H. & Nakatani, Y. The transcriptional co-activators p300 and CBP are histone acetyltransferases. Cell 87 , 953–959 (1996).
    Article CAS Google Scholar
  32. Grunstein, M. Histone acetylation in chromatin structure and transcription. Nature 389, 349–352 ( 1997).
    Article CAS Google Scholar
  33. Trouche, D. & Kouzarides, T. E2F-1 and E1A 12S have a homologous activation domain regulated by RB and CBP. Proc. Natl. Acad. Sci. USA 93, 1439–1442 ( 1996).
    Article CAS Google Scholar
  34. Lee, C-W., Sørensen, T. S., Shikama, N. & La Thangue, N. B. Functional interplay between p53 and E2F through co-activator p300. Oncogene 16, 2695–2710 ( 1998).
    Article CAS Google Scholar
  35. Johnston, L. H. & Lowndes, N. F. Cell cycle control of DNA synthesis in budding yeast. Nucleic Acids Res. 20, 2403–2410 (1992).
    Article CAS Google Scholar
  36. Taylor, I. A., Treiber, M. K., Olivi, L. & Smerdon, S. J. The X-ray structure of the DNA-binding domain from the Saccharomyces cerevisiae cell cycle transcription factor Mbp1 at 2.1 Å resolution. J. Mol. Biol. 272, 1–8 ( 1997).
    Article CAS Google Scholar
  37. Zheng, N., Fraenkel, E., Pabo, C. O. & Pavletich, N. P. Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev. 13, 666– 674 (1999).
    Article CAS Google Scholar
  38. Chrivia, J.C. et al. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855–859 (1993.)
    Article CAS Google Scholar
  39. Lambert, P. F., Kashanchi, F., Radonovich, M. F., Shiekhattar, R. & Brady, J. N. Phosphorylation of p53 serine 15 increases interaction with CBP. J. Biol. Chem. 49, 33048–33053 ( 1998).
    Article Google Scholar
  40. Shikama, N. et al. A new co-factor for p300 that regulates the p53 response. Mol. Cell 4, 365–376 ( 1999).
    Article CAS Google Scholar
  41. Bandara, L. R., Buck, V. M., Zamanian, M., Johnston, L. H. & La Thangue, N. B. Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F . EMBO J. 12, 4317–4324 (1993).
    Article CAS Google Scholar
  42. Allen, K. E., de la Luna, S., Kerkhoven, R. M., Bernards, R. & La Thangue, N. B. Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors . J. Cell Sci. 110, 2819– 2831 (1997).
    CAS PubMed Google Scholar
  43. Zerfass-Thome, K. et al. p27(KIP1) blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol. Cell Biol. 17, 407 –415 (1997).
    Article CAS Google Scholar
  44. Van den Heuvel, S. & Harlow, E. Distinct roles for cyclin-dependent kinases in cell-cycle control. Science 262, 2050–2054 (1993).
    Article CAS Google Scholar
  45. Desai, D., Wessling, H. C., Fisher, R. P. & Morgan, D. O. Effects of phosphorylation by CAK on cyclin binding by cdc2 and cdk2. Mol. Cell Biol. 15, 345–350 (1995).
    Article CAS Google Scholar
  46. de la Luna, S., Allen, K. E., Mason, S. L. & La Thangue, N. B. Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F ranscription factor. EMBO J. 18, 212–228 (1999).
    Article CAS Google Scholar
  47. Bandara, L.R. et al. DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. EMBO J. 13, 3104–3114 (1994).
    Article CAS Google Scholar
  48. Girling, R. et al. A new component of the transcription factor DRTF1/E2F. Nature 362, 83–87 ( 1993).
    Article CAS Google Scholar
  49. de la Luna, S., Burden, M. J., Lee, C-W. & La Thangue, N.B. Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal. J. Cell Sci. 109 2443– 2452 (1996).
  50. Luo, K. & Sefton, B. M. Transfer of proteins to membranes facilitates both cyanogen bromide cleavage and two dimensional proteolytic mapping. Oncogene 5, 921– 923 (1990).
    CAS PubMed Google Scholar

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