Thrombin signalling and protease-activated receptors (original) (raw)

• Colman, R. W., Marder, V. J., Salzman, E. W. & Hirsh, J. in Hemostasis and Thrombosis (eds Colman, R. W., Marder, V. J., Salzman, E. W. & Hirsh, J.) 3–18 (Lippincott, Philadelphia, 1994).
  Google Scholar
• Esmon, C. T. et al. Inflammation, sepsis, and coagulation. Haematologica 84, 254–259 ( 1999).
  CAS PubMed Google Scholar
• Osterud, B. Tissue factor expression by monocytes: regulation and pathophysiological roles . Blood Coag. Fibrin. 9(Suppl. 1), S9–S14 (1998).
  CAS Google Scholar
• Giesen, P. L. et al. Blood-borne tissue factor: another view of thrombosis. Proc. Natl Acad. Sci. USA 96, 2311– 2315 (1999).
  Article ADS CAS Google Scholar
• Bevilacqua, M. P. & Gimbrone, M. A. Jr Inducible endothelial functions in inflammation and coagulation. Semin. Thromb. Hemost. 13, 425–433 (1987).
  Article CAS Google Scholar
• Coughlin, S. R. Sol Sherry lecture in thrombosis: how thrombin ‘talks’ to cells: molecular mechanisms and roles in vivo. Arterioscl. Thromb. Vasc. Biol. 18, 514–518 (1998).
  Article CAS Google Scholar
• Stenberg, P. E., McEver, R. P., Shuman, M. A., Jacques, Y. V. & Bainton, D. F. A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J. Cell Biol. 101, 880–886 (1985).
  Article CAS Google Scholar
• Henn, V. et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391, 591– 594 (1998).
  Article ADS CAS Google Scholar
• Hughes, P. E. & Pfaff, M. Integrin affinity modulation. Trends Cell Biol. 8, 359–364 (1998).
  Article CAS Google Scholar
• Sims, P. J., Wiedmer, T., Esmon, C. T., Weiss, H. J. & Shattil, S. J. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. J. Biol. Chem. 264, 17049–17057 (1989).
  CAS PubMed Google Scholar
• Hattori, R., Hamilton, K. K., Fugate, R. D., McEver, R. P. & Sims, P. J. Stimulated secretion of endothelial vWF is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140. J. Biol. Chem. 264 , 7768–7771 (1989).
  CAS PubMed Google Scholar
• Subramaniam, M. et al. Defects in hemostasis in P-selectin-deficient mice. Blood 87, 1238–1242 ( 1996).
  CAS PubMed Google Scholar
• Frenette, P. S., Mayadas, T. N., Rayburn, H., Hynes, R. O. & Wagner, D. D. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell 84, 563–574 ( 1996).
  Article CAS Google Scholar
• Lum, H. & Malik, A. B. Regulation of vascular endothelial barrier function. Am. J. Physiol. 267, L223 –L241 (1994).
  CAS PubMed Google Scholar
• Cirino, G. et al. Thrombin functions as an inflammatory mediator through activation of its receptor. J. Exp. Med. 183, 821– 827 (1996).
  Article CAS Google Scholar
• Coughlin, S. R. How the protease thrombin talks to cells. Proc. Natl Acad. Sci. USA 96, 11023–11027 ( 1999).
  Article ADS CAS Google Scholar
• Vu, T.-K. H., Hung, D. T., Wheaton, V. I. & Coughlin, S. R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64, 1057–1068 (1991).
  Article CAS Google Scholar
• Rasmussen, U. B. et al. cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization. FEBS Lett. 288, 123–128 (1991).
  Article CAS Google Scholar
• Chen, J., Ishii, M., Wang, L., Ishii, K. & Coughlin, S. R. Thrombin receptor activation: confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode. J. Biol. Chem. 269, 16041–16045 (1994).
  CAS PubMed Google Scholar
• O'Brien, P. J. et al. Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. J. Biol. Chem. 275, 13502– 13509 (2000).
  Article CAS Google Scholar
• Ishii, K., Hein, L., Kobilka, B. & Coughlin, S. R. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. J. Biol. Chem. 268, 9780–9786 (1993).
  CAS PubMed Google Scholar
• Bernatowicz, M. S. et al. Development of potent thrombin receptor antagonist peptides . J. Med. Chem. 39, 4879– 4887 (1996).
  Article CAS Google Scholar
• Ishihara, H. et al. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 386, 502– 506 (1997).
  Article ADS CAS Google Scholar
• Xu, W. F. et al. Cloning and characterization of human protease-activated receptor 4. Proc. Natl Acad. Sci. USA 95, 6642– 6646 (1998).
  Article ADS CAS Google Scholar
• Kahn, M. L. et al. A dual thrombin receptor system for platelet activation. Nature 394, 690–694 ( 1998).
  Article ADS CAS Google Scholar
• Nystedt, S., Emilsson, K., Wahlestedt, C. & Sundelin, J. Molecular cloning of a potential novel proteinase activated receptor. Proc. Natl Acad. Sci. USA 91, 9208– 9212 (1994).
  Article ADS CAS Google Scholar
• Molino, M. et al. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J. Biol. Chem. 272, 4043– 4049 (1997).
  Article CAS Google Scholar
• Camerer, E., Huang, W. & Coughlin, S. R. Tissue factor- and Factor X-dependent activation of PAR2 by Factor VIIa. Proc. Natl Acad. Sci. USA 97 , 5255–5260 (2000).
  Article ADS CAS Google Scholar
• Nakanishi-Matsui, M. et al. PAR3 is a cofactor for PAR4 activation by thrombin. Nature 404, 609–613 ( 2000).
  Article ADS CAS Google Scholar
• Kahn, M. L., Nakanishi-Matsui, M., Shapiro, M. J., Ishihara, H. & Coughlin, S. R. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J. Clin. Invest. 103, 879–887 ( 1999).
  Article CAS Google Scholar
• Hung, D. T., Vu, T. K., Wheaton, V. I., Ishii, K. & Coughlin, S. R. Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. J. Clin. Invest. 89, 1350–1353 ( 1992).
  Article CAS Google Scholar
• Brass, L. F. et al. Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus. J. Biol. Chem. 267, 13795–13798 (1992).
  CAS PubMed Google Scholar
• Selak, M. A., Chignard, M. & Smith, J. B. Cathepsin G is a strong platelet agonist released by neutrophils. Biochem. J. 251, 293– 299 (1988).
  Article CAS Google Scholar
• Sambrano, G. R. et al. Cathepsin G activates protease-activated receptor-4 in human platelets. J. Biol. Chem. 275, 6819– 6823 (2000).
  Article CAS Google Scholar
• Shapiro, M. J., Weiss, E. J., Faruqi, T. R. & Coughlin, S. R. Protease-activated receptors 1 and 4 are shutoff with distinct tempos after activation by thrombin. J. Biol. Chem. (in the press).
• Okamura, T., Hasitz, M. & Jamieson, G. A. Platelet glycocalicin: interaction with thrombin and role as thrombin receptor on the platelet surface. J. Biol. Chem. 253, 3435–3443 ( 1978).
  Google Scholar
• Andrews, R. K. et al. The glycoprotein Ib-IX-V complex in platelet adhesion and signaling. Thromb. Haemost. 82, 357– 364 (1999).
  Article CAS Google Scholar
• Connolly, T. M. et al. Species variability in platelet and other cellular responsiveness to thrombin receptor-derived peptides. Thromb. Haemost. 72, 627–633 (1994).
  Article CAS Google Scholar
• Derian, C. K., Santulli, R. J., Tomko, K. A., Haertlein, B. J. & Andrade-Gordon, P. Species differences in platelet responses to thrombin and SFLLRN. Receptor-mediated calcium mobilization and aggregation and regulation by protein kinases. Thromb. Res. 6, 505–519 (1995).
  Article Google Scholar
• Connolly, A. J., Ishihara, H., Kahn, M. L., Farese, R. V. & Coughlin, S. R. Role of the thrombin receptor in development and evidence for a second receptor. Nature 381, 516–519 (1996).
  Article ADS CAS Google Scholar
• Zimmerman, G. A. et al. Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions. Adv. Exp. Med. Biol. 416 , 297–304 (1996).
  Article CAS Google Scholar
• Johnson, K. et al. Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation. J. Immunol. 160 , 5130–5135 (1998).
  CAS PubMed Google Scholar
• Cunningham, M. A. et al. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J. Exp. Med. 191, 455–462 (2000).
  Article CAS Google Scholar
• Bugge, T. H., et al. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc. Natl Acad. Sci. USA 93, 6258–6263 (1996).
  Article ADS CAS Google Scholar
• Hung, D. T., Wong, Y. H., Vu, T.-K. H. & Coughlin, S. R. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate both phosphoinositide hydrolysis and inhibit adenylyl cyclase . J. Biol. Chem. 353, 20831– 20834 (1992).
  Google Scholar
• Offermanns, S., Laugwitz, K.-L., Spicher, K. & Schultz, G. G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc. Natl Acad. Sci. USA 91, 504–508 (1994).
  Article ADS CAS Google Scholar
• Barr, A. J., Brass, L. F. & Manning, D. R. Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor–G protein coupling. J. Biol. Chem. 272 , 2223–2229 (1997).
  Article CAS Google Scholar
• Kozasa, T. et al. p115 RhoGEF, a GTPase-activating protein for Galpha12 and Galpha13. Science 280, 2109– 2111 (1998).
  Article CAS Google Scholar
• Hart, M. J. et al. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Gα13 Science 280 , 2112–2114 (1998).
  Article ADS CAS Google Scholar
• Fukuhara, S., Murga, C., Zohar, M., Igishi, T. & Gutkind, J. S. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J. Biol. Chem. 274, 5868–5879 ( 1999).
  Article CAS Google Scholar
• Klages, B., Brandt, U., Simon, M. I., Schultz, G. & Offermanns, S. Activation of G12/G13 results in shape change and rho/rho kinase-mediated myosin light chain phosphorylation in mouse platelets. J. Cell. Biol. 144, 745–754 (1999).
  Article CAS Google Scholar
• Vouret-Craviari, V., Boquet, P., Pouysségur, J. & Van Obberghen-Schilling, E. Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function. Mol. Biol. Cell 9, 2639–2653 (1998).
  Article CAS Google Scholar
• Offermanns, S., Mancino, V., Revel, J.-P. & Simon, M. I. Vascular system defects and impaired cell chemokinesis as a result of Gα 13 deficiency. Science 275, 533– 536 (1997).
  Article CAS Google Scholar
• Taylor, S., Chae, H. Z., Rhee, S.-G. & Exton, J. H. Activation of the B1 isozyme of phospholipase C by a subunits of the Gq class of G proteins . Nature 350, 516–518 (1991).
  Article ADS CAS Google Scholar
• Offermanns, S., Toombs, C. F., Hu, Y. H. & Simon, M. I. Defective platelet activation in Gαq-deficient mice. Nature 389, 183–186 (1997).
  Article ADS CAS Google Scholar
• Stoyanov, B. et al. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269, 690–693 (1995).
  Article ADS CAS Google Scholar
• Clapham, D. E. & Neer, E. J. G protein beta gamma subunits. Annu. Rev. Pharmacol. Toxicol. 37, 167–203 (1997).
  Article CAS Google Scholar
• Leevers, S. J., Vanhaesebroeck, B. & Waterfield, M. D. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr. Opin. Cell Biol. 11 , 219–225 (1999).
  Article CAS Google Scholar
• Prenzel, N. et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402, 884–888 (1999).
  Article ADS CAS Google Scholar
• Esmon, C. T. Introduction: are natural anticoagulants candidates for modulating the inflammatory response to endotoxin? Blood 95, 1113– 1116 (2000).
  CAS PubMed Google Scholar
• Esmon, C. T. et al. Regulation and functions of the protein C anticoagulant pathway . Haematologica 84, 363– 368 (1999).
  CAS PubMed Google Scholar
• Palabrica, T. et al. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature 359, 848–851 (1992).
  Article ADS CAS Google Scholar
• Nystedt, S., Ramakrishnan, V. & Sundelin, J. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor . J. Biol. Chem. 271, 14910– 14915 (1996).
  Article CAS Google Scholar
• Inbal, A. et al. Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency. Thromb. Haemost. 77, 1086–1089 (1997).
  Article CAS Google Scholar