Endonuclease G is an apoptotic DNase when released from mitochondria (original) (raw)

• Wyllie, A. H. Glucocorticoid induced thymocyte apoptosis is associated with endogeneous endonuclease activation. Nature 284, 555–556 (1980).
  Article ADS CAS PubMed Google Scholar
• Liu, X. et al. DFF, heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89, 175–184 (1997).
  Article CAS PubMed Google Scholar
• Liu, X. et al. DFF40 induces DNA fragmentation and chromatin condensation during apoptosis. Proc. Natl Acad. Sci. USA 15, 8461–8466 (1998).
  Article ADS MathSciNet Google Scholar
• Enari, M. et al. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391, 43–50 (1998).
  Article ADS CAS PubMed Google Scholar
• Zhang, H. et al. Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc. Natl Acad. Sci. USA 95, 12480–12485 (1998).
  Article ADS CAS PubMed PubMed Central Google Scholar
• McIlroy, D. et al. An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes. Genes Dev. 14, 549–558 (2000).
  CAS PubMed PubMed Central Google Scholar
• Zhang, J. H. & Xu, M. DNA fragmentation in apoptosis. Cell Res. 10, 205–211 (2000).
  Article CAS PubMed Google Scholar
• Li, H. et al. Cleavage of Bid by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94, 615–624 (1998).
  Article Google Scholar
• Luo, X. et al. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptor. Cell 94, 481–490 (1998).
  Article CAS PubMed Google Scholar
• Gross, A. et al. Caspase cleaved BID targets mitochondria and is required for cytochome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J. Biol. Chem. 274, 1156–1163 (1999).
  Article CAS PubMed Google Scholar
• Tiranti, V. et al. Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis. Genomics 25, 559–564 (1995).
  Article CAS PubMed Google Scholar
• Cote, J. & Ruiz-Carrillo, A. Primers for mitochondrial DNA replication generated by endonuclease G. Science 261, 765–769 (1993).
  Article ADS CAS PubMed Google Scholar
• Krammer, P. H. CD95's deadly mission in the immune system. Nature 407, 789–795 (2000).
  Article ADS CAS PubMed Google Scholar
• Kluck, R. M. et al. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275, 1132–1136 (1997).
  Article CAS PubMed Google Scholar
• Puthalakath, H. et al. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol. Cell 3, 287–296 (1999).
  Article CAS PubMed Google Scholar
• Von Ahsen, O. et al. Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release. J. Cell Biol. 150, 1027–1036 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Ikeda, S. & Ozaki, K. Action of mitochondrial endonuclease G on DNA damaged by l-asorbic acid, peplomycin, and cis-Diamminedichloroplatinum (II). Biochem. Biophys. Res. Commun. 235, 291–294 (1997).
  Article CAS PubMed Google Scholar
• Xiang, J., Chao, D. T. & Korsmeyer, S. J. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc. Natl Acad. Sci. USA 93, 14559–14563 (1996).
  Article ADS CAS PubMed PubMed Central Google Scholar
• Zou, H. et al. An APAF-1 cytochrome C multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274, 11549–11556 (1999).
  Article CAS PubMed Google Scholar
• Du, C. et al. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102, 33–42 (2000).
  Article CAS PubMed Google Scholar
• Verhagen, A. et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102, 43–53 (2000).
  Article CAS PubMed Google Scholar
• Susin, S. A. et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397, 441–446 (1999).
  Article ADS CAS PubMed Google Scholar
• Lindsten, T. et al. The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues. Mol. Cell 6, 1389–1399 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Kuida, K. et al. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384, 368–372 (1996).
  Article ADS CAS PubMed Google Scholar
• Hakem, R. et al. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94, 339–352 (1998).
  Article CAS PubMed Google Scholar
• Kuida, K. et al. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94, 325–337 (1998).
  Article CAS PubMed Google Scholar
• Cecconi, F. et al. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94, 727–737 (1998).
  Article CAS PubMed Google Scholar
• Yoshida, H. et al. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94, 739–750 (1998).
  Article CAS PubMed Google Scholar
• Honarpour, N. et al. Adult Apaf-1-deficient mice exhibit male infertility. Dev. Biol. 218, 248–258 (2000).
  Article CAS PubMed Google Scholar
• Chautan, M. et al. Interdigital cell death can occur through a necrotic and caspase-independent pathway. Curr. Biol. 9, 967–970 (1999).
  Article CAS PubMed Google Scholar