A second-generation linkage map of the human genome (original) (raw)

Nature volume 359, pages 794–801 (1992)Cite this article

Abstract

A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to ∼90% of the estimated length of the human genome.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Williamson, R. et al. Cytogenet. Cell Genet. 58, 1190–1832 (1991).
    Article ADS Google Scholar
  2. Donis-Keller, H. et al. Cell 51, 319–337 (1987).
    Article CAS PubMed Google Scholar
  3. White, R. et al. in Genetics Maps. Locus Maps of Complex Genomes 5th edn (O'Brian S. J.) 5.134–5.157 (Cold Spring Harbor Laboratory Press. New York, 1990).
    Google Scholar
  4. NIH/CEPH Collaborative mapping group Science 258, 67–86 (1992).
  5. Bishop, D. T. & Williamson, J. A. Am. J. hum. Genet. 46, 254–265 (1990).
    CAS PubMed PubMed Central Google Scholar
  6. Risch, N. Am. J. hum. Genet 46, 242–253 (1990).
    CAS PubMed PubMed Central Google Scholar
  7. Nakamura, Y. et al. Science 235, 1616–1622 (1987).
    Article ADS CAS PubMed Google Scholar
  8. Vergnaud, G., Maria, D., Zoroastro, M. & Lauthier, V. Electrophoresis 12, 134–140 (1991).
    Article CAS PubMed Google Scholar
  9. Litt, M. & Luty, J. A. Am. J. hum. Genet 44, 397–401 (1989).
    CAS PubMed PubMed Central Google Scholar
  10. Weber, J. L. & May, P. E. Am. J. hum. Genet. 44, 388–396 (1989).
    CAS PubMed PubMed Central Google Scholar
  11. Church, G. M. & Kieffer-Higgins, S. Science 240, 185–188 (1988).
    Article ADS CAS PubMed Google Scholar
  12. Hazan, J. et al. Genomics 12, 183–189 (1992).
    Article CAS PubMed Google Scholar
  13. Viginal, A. et al. in Methods in Molecular Genetics Vol. 1 (ed. Adolph, K. W.) (Academic, Orlando, in the press).
  14. Beckmann, J. S. & Weber, J. L. Genomics 12, 627–631 (1992).
    Article CAS Google Scholar
  15. Lathrop, G. M. & Lalouel, J. M. Am. J. hum. Genet 36, 460–465 (1985).
    Google Scholar
  16. Cytogenet Cell Genet. 58, 1–2200 (1991).
  17. Ott, J. Am. J. hum. Genet 51, 283–290 (1992).
    CAS PubMed PubMed Central Google Scholar
  18. Dietrich, W. et al. Genetics 131, 423–447 (1992).
    CAS PubMed PubMed Central Google Scholar
  19. Smith, L. M. et al. Nature 321, 674–679 (1986).
    Article ADS CAS PubMed Google Scholar
  20. Saluz, H. & Jost, J. P. Prop. natn. Acad. Sci. U.S.A. 86, 2602–2606 (1989).
    Article ADS CAS Google Scholar
  21. Rychlik, W. & Rhoads, R. E. Nucleic Acids Res. 17, 8543–8551 (1989).
    Article CAS PubMed PubMed Central Google Scholar
  22. Morton, N. E. Proc. natn. Acad. Sci. U.S.A. 88, 7474–7476 (1991).
    Article ADS CAS Google Scholar
  23. Lathrop, G. M. et al. Genomics 2, 157–164 (1988).
    Article CAS PubMed Google Scholar
  24. Lathrop, G. M. & Lalouel, J. M. Stat. Meth. biol. Med. Sci. 8, 81–123 (1991).
    Article Google Scholar

Download references

Author information

Authors and Affiliations

  1. Genethon, 1 rue de I'lnternationale, 91000, Evry, France
    Jean Weissenbach, Gabor Gyapay, Colette Dib, Alain Vignal, Jean Morissette, Philippe Millasseau & Guy Vaysseix
  2. Unité de Génétique Moléculaire Humaine, CNRS LIRA 1445, Institut Pasteur, 75724, Paris cédex, France
    Jean Weissenbach
  3. Centre d'Etudes du Polymorphisme Humain (CEPH), Centre Hospitalier de I'Université Laval, Québec, Canada
    Gabor Gyapay, Philippe Millasseau & Mark Lathrop
  4. Réseau de Médecine Génétique, Centre Hospitalier de I'Université Laval, Québec, Canada
    Jean Morissette
  5. INSERM U 358, 27 Rue Juliette Dodu, 75010, Paris, France
    Mark Lathrop

Authors

  1. Jean Weissenbach
    You can also search for this author inPubMed Google Scholar
  2. Gabor Gyapay
    You can also search for this author inPubMed Google Scholar
  3. Colette Dib
    You can also search for this author inPubMed Google Scholar
  4. Alain Vignal
    You can also search for this author inPubMed Google Scholar
  5. Jean Morissette
    You can also search for this author inPubMed Google Scholar
  6. Philippe Millasseau
    You can also search for this author inPubMed Google Scholar
  7. Guy Vaysseix
    You can also search for this author inPubMed Google Scholar
  8. Mark Lathrop
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Weissenbach, J., Gyapay, G., Dib, C. et al. A second-generation linkage map of the human genome.Nature 359, 794–801 (1992). https://doi.org/10.1038/359794a0

Download citation