Calcium-dependent immediate feedback control of inositol 1,4,5-trisphosphate-induced Ca2+ release (original) (raw)
- Letter
- Published: 05 November 1992
Nature volume 360, pages 76–78 (1992)Cite this article
- 236 Accesses
- 266 Citations
- 3 Altmetric
- Metrics details
Abstract
THE temporal and spatial distribution of increases in intracellular Ca2+ concentration is an important factor in cellular signal transdaction1. Inositol 1,4,5-trisphosphate (InsP3) plays a key part in agonist-induced Ca2+ release1, which can take place abruptly2 and in a confined space3 by a mechanism that is not fully understood. Here we analyse the kinetics of InsP3-induced Ca2+ release following flash photolysis4–7 of caged InsP3 or caged Ca2+, and demonstrate that Ca2+-dependent immediate feedback control is an important determinant of the time course of Ca2+ release. The positive feedback mechanism is also important for the 'loading dependence' of InsP3-induced Ca22+ release8. Furthermore, our results support the operation of positive cooperativity in channel opening9 and feedback control augments the steep InsP3 concentration-Ca2+ release relation. These inherent properties of InsP3-induced Ca2+ release are expected to give rise to temporally abrupt and/or spatially confined Ca2+ release within the cell.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Berridge, M. J. & Irvine, R. F. Nature 341, 197–205 (1989).
Article ADS CAS Google Scholar - Miyazaki, S. J. Cell Biol. 106, 345–353 (1988).
Article CAS Google Scholar - Parker, I. & Ivorra, I. Science 250, 977–979 (1990).
Article ADS CAS Google Scholar - McCray, J. A. & Trentham, D. R. A. Rev. Biophys. biophys. Chem. 18, 239–270 (1989).
Article CAS Google Scholar - Somlyo, A. P. & Somlyo, A. V. A. Rev. Physiol 52, 857–874 (1990).
Article CAS Google Scholar - Blatt, M. R., Thiel, G. & Trentham, D. R. Nature 346, 766–769 (1990).
Article ADS CAS Google Scholar - Kaplan, J. A. A. Rev. Physiol. 52, 897–914 (1990).
Article CAS Google Scholar - Missiaen, L., Taylor, C. W. & Berridge, M. J. Nature 352, 241–244 (1991).
Article ADS CAS Google Scholar - Meyer, T., Holowka, D. & Stryer, L. Science 240, 653–656 (1988).
Article ADS CAS Google Scholar - Minta, A., Kao, J. P. Y. & Tsien, R. Y. J. biol. Chem. 264, 8171–8178 (1989).
CAS Google Scholar - Iino, M. J. gen. Physiol. 98, 681–698 (1991).
Article CAS Google Scholar - Iino, M. J. gen. Physiol. 95, 1103–1122 (1990).
Article CAS Google Scholar - Bezprozvanny, I., Watras, J. & Ehrlich, B. E. Nature 351, 751–754 (1991).
Article ADS CAS Google Scholar - Fleischer, S. & Inui, M. A. Rev. Biophys. biophys. Chem. 18, 333–364 (1989).
Article CAS Google Scholar - Irvine, R. F. FEBS Lett. 263, 5–9 (1990).
Article CAS Google Scholar - Finch, E. A., Turner, T. & Goldin, S. M. Science 252, 443–446 (1991).
Article ADS CAS Google Scholar - Watras, J., Bezprozvanny, I. & Ehrlich, B. E. J. Neurosci. 11, 3239–3245 (1991).
Article CAS Google Scholar - Berridge, M. J. J. biol. Chem. 265, 9583–9586 (1990).
CAS Google Scholar - Meyer, T. Cell 64, 675–678 (1991).
Article CAS Google Scholar - Jaffe, L. F. Proc. natn. Acad. Sci. U.S.A. 88, 9883–9887 (1991).
Article ADS CAS Google Scholar - Kasai, H. & Augustine, G. J. Nature 348, 735–738 (1990).
Article ADS CAS Google Scholar - Lechleiter, J., Girard, S., Peralta, E. & Clapham, D. Science 252, 123–126 (1991).
Article ADS CAS Google Scholar - Iino, M. J. gen. Physiol. 94, 363–383 (1989).
Article CAS Google Scholar - Downes, C. P., Mussat, M. C. & Michell, R. H. Biochem. J. 203, 169–177 (1982).
Article CAS Google Scholar
Author information
Authors and Affiliations
- Department of Pharmacology, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113, Japan
Masamitsu Iino & Makoto Endo
Authors
- Masamitsu Iino
You can also search for this author inPubMed Google Scholar - Makoto Endo
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Iino, M., Endo, M. Calcium-dependent immediate feedback control of inositol 1,4,5-trisphosphate-induced Ca2+ release.Nature 360, 76–78 (1992). https://doi.org/10.1038/360076a0
- Received: 27 May 1992
- Accepted: 11 September 1992
- Issue Date: 05 November 1992
- DOI: https://doi.org/10.1038/360076a0