Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease (original) (raw)

References

1. Katzman, R. N. Engl. J. Med. 314, 964–973 (1986).
   Article CAS Google Scholar
2. St George-Hyslop, P. H. et al. Nature 347, 194–197 (1991).
   Article ADS Google Scholar
3. Strittmatter, W. J. et al. Proc. natn. Acad. Sci. U.S.A. 90, 1977–1981 (1993).
   Article CAS ADS Google Scholar
4. Saunders, A. et al. Neurology 43, 1467–1472 (1993).
   Article CAS Google Scholar
5. Goate, A. M. et al. Nature 349, 704–706 (1991).
   Article CAS ADS Google Scholar
6. Chartier-Harlin, M.-C. et al. Nature 353, 844–846 (1991).
   Article CAS ADS Google Scholar
7. Murrell, J., Farlow, M., Ghetti, B. & Benson, M. D. Science 254, 97–99 (1991).
   Article CAS ADS Google Scholar
8. Karlinsky, H. et al. Neurology 42, 1445–1453 (1992).
   Article CAS Google Scholar
9. Schellenberg, G. D. et al. Science 258, 668–670 (1992).
   Article CAS ADS Google Scholar
10. St George-Hyslop, P. et al. Nature Genet. 2, 330–334 (1992).
    Article CAS Google Scholar
11. Van Broeckhoven, C. et al. Nature Genet. 2, 335–339 (1992).
    Article CAS Google Scholar
12. Rogaev, E. I. et al. Neurology 43, 2275–2279 (1993).
    Article CAS Google Scholar
13. Wong, L. et al. Neurosci. Lett. 152, 96–98 (1993).
    Article CAS Google Scholar
14. Nee, L. et al. Archs Neurol. 40, 203–208 (1983).
    Article CAS Google Scholar
15. Frommelt, P., Schnabel, R., Kuhne, W., Nee, L. E. & Polinsky, R. J. Alzheimer Dis. Ass. Disorders 5, 36–43 (1991).
    Article CAS Google Scholar
16. Goudsmit, J. et al. J. neurol. Sci. 49, 78–89 (1981).
    Article Google Scholar
17. Pollen, D. Hannah's Heirs: the Quest for the Genetic Origins of Alzheimer's Disease (Oxford Univ. Press, Oxford, 1993).
    Google Scholar
18. Foncin, J.-F. et al. Rev. Neurol. 141, 194–202 (1985).
    CAS PubMed Google Scholar
19. Bergamini, L. et al. Acta neurol. 13, 534–538 (1991).
    CAS Google Scholar
20. Pericak-Vance, M. A., Yamoaka, L. H. & Haynes, C. S. Expl Neurol. 102, 271–279 (1988).
    Article CAS Google Scholar
21. Cruts, M. et al. Neurobiol Aging 15, S129 (1994).
    Google Scholar
22. Kerem, B.-S. et al. Science 245, 1073–1080 (1989).
    Article CAS ADS Google Scholar
23. Gusella, J. F. & Group, H. D. C. Cell 72, 971–983 (1993).
    Article Google Scholar
24. Rommens, J. M. et al. Hum. molec. Genet. 2, 901–907 (1993).
    Article CAS Google Scholar
25. Saleeba, J. A. & Cotton, R. G. Meth. Enzym. 217, 285–295 (1993).
    Google Scholar
26. Liu, Q. & Sommer, S. S. BioTechniques 18, 470–476 (1995).
    CAS PubMed Google Scholar
27. Kozak, M. J. biol. Chem. 266, 19867–19870 (1991).
    CAS PubMed Google Scholar
28. Rost, B. & Sander, C. Proteins 19, 55–72 (1994).
    Article CAS Google Scholar
29. Kyte, J. & Doolittle, R. F. J. molec. Biol. 157, 105 (1982).
    Article CAS Google Scholar
30. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. molec. Biol. 215, 403–410 (1990).
    Article CAS Google Scholar
31. L'Hernault, S. W. L. & Arduengo, P. M. J. Cell Biol. 119, 55–69 (1992).
    Article CAS Google Scholar
32. Schellenberg, G. D. et al. Am. J. hum. Genet. 53, 619–628 (1993).
    CAS PubMed PubMed Central Google Scholar
33. St George-Hyslop, P. H. et al. Science 263, 536–537 (1994).
    Article ADS Google Scholar
34. Kosik, K. & Greenberg, S. M. in Alzheimer Disease (eds Terry, R. D., Katzman, R. & Bick, K. L.) 335–344 (Raven, New York, 1994).
    Google Scholar
35. Selkoe, D. J. A. Rev. Neurosci. 17, 489–517 (1994).
    Article CAS Google Scholar
36. MacLennan, D. H. et al. Nature 343, 559–561 (1990).
    Article CAS ADS Google Scholar
37. Ptacek, L. J. et al. Cell 67, 1021–1027 (1991).
    Article CAS Google Scholar
38. Chalfie, M. & Wolinsky, E. Nature 345, 410–416 (1990).
    Article CAS ADS Google Scholar
39. Driscoll, M. & Chalfie, M. Nature 349, 588–593 (1991).
    Article CAS ADS Google Scholar
40. Etcheberrigaray, R. et al. Proc. natn. Acad. Sci. U.S.A. 90, 8209–8213 (1994).
    Article ADS Google Scholar
41. Mattson, M. P. et al. Trends Neurosci. 16, 409–414 (1993).
    Article CAS Google Scholar
42. Querfurth, H. W. & Selkoe, D. J. Biochemistry 33, 4550–4561 (1994).
    Article CAS Google Scholar
43. Weissenbach, J. et al. Nature 359, 794–798 (1992).
    Article CAS ADS Google Scholar
44. NIH/CEPH Collaborative Mapping Group. Science 258, 67–86 (1992).
45. Gyapay, G. et al. Nature Genet. 7, 246–339 (1994).
    Article CAS Google Scholar
46. Albertsen, H. M. et al. Proc. natn. Acad. Sci. U.S.A. 87, 4256–4260 (1990).
    Article CAS ADS Google Scholar
47. Chumakov, I. M. et al. Nature Genet. 1, 222–225 (1992).
    Article CAS Google Scholar
48. Ioannu, P. A. et al. Nature Genet. 6, 84–89 (1994).
    Article Google Scholar
49. Chumakov, I. et al. Nature 359, 380–387 (1992).
    Article CAS ADS Google Scholar
50. Riley, J. et al. Nucleic Acids Res. 18, 2887–2890 (1990).
    Article CAS Google Scholar

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Author notes

1. P. H. St George-Hyslop: To whom correspondence should be addressed

Authors and Affiliations

1. Centre for Research into Neurodegenerative Diseases, Departments of Medicine (Neurology) and Medical Biophysics, University of Toronto, Toronto, and Department of Medicine, Division of Neurology, The Toronto Hospital, Toronto, Ontario, M5S 1A8, Canada
   R. Sherrington, E. I. Rogaev, Y. Liang, E. A. Rogaeva, G. Levesque, M. Ikeda, H. Chi, C. Lin, G. Li, K. Holman, T. Tsuda, P. E. Fraser & P. H. St George-Hyslop
2. Research Institute, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
   L. Mar & J. M. Rommens
3. Laboratoire de Neurohistologie, Ecole Pratique des Hautes Etudes and U106, INSERM La Salpetriere, 75651, Paris, Cedex 13, France
   J.-F. Foncin
4. USL-6 and UO-CNR, 88046, Lamezia Terme, Italy
   A. C. Bruni & M. P. Montesi
5. Department of Neurology and Psychiatry, University of Florence, viale Morgagni 85, Florence, Italy
   S. Sorbi
6. Department of Neurology, University of Turin, via Cherasco 15, 10126, Turin, Italy
   I. Rainero & L. Pinessi
7. Clinical Neuropharmaeology Section, NINDS, 9000 Rockville Pike, Bethesda, Maryland, 20892, USA
   L. Nee
8. Centre d'Etude Polymorphisme Humaine, 27 Rue Juliette Dodu, 75010, Paris, France
   I. Chumakov
9. Department of Neurology, University of Massachusetts Medical Center, 55 Lake Avenue, Worcester, Massachusetts, 01655, USA
   D. Pollen
10. Molecular Neurogenetics Laboratory and Laboratory of Genetics and Aging, Massachusetts General Hospital, Departments of Neurology and Genetics, Harvard Medical School, Boston, Massachusetts, 02114, USA
    W. Wasco, J. L. Haines & R. E. Tanzi
11. Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, North Carolina, 27710, USA
    H. A. R. Da Silva, M. A. Pericak-Vance & A. D. Roses
12. Molecular Pathology, Glaxo Research and Development, Greenford Road, Greenford, Middlesex, UB6 OHE, UK
    P. Sanseau
13. Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, 59 Route 10, East Hanover, New Jersey, 07936, USA
    R. J. Polinsky
14. MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, UK
    A. Brookes

Authors

1. R. Sherrington
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2. E. I. Rogaev
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3. Y. Liang
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4. E. A. Rogaeva
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5. G. Levesque
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6. M. Ikeda
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7. H. Chi
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8. C. Lin
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9. G. Li
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10. K. Holman
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11. T. Tsuda
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12. L. Mar
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13. J.-F. Foncin
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14. A. C. Bruni
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15. M. P. Montesi
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16. S. Sorbi
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17. I. Rainero
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18. L. Pinessi
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19. L. Nee
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20. I. Chumakov
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21. D. Pollen
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22. A. Brookes
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23. P. Sanseau
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24. R. J. Polinsky
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25. W. Wasco
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26. H. A. R. Da Silva
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27. J. L. Haines
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28. M. A. Pericak-Vance
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29. R. E. Tanzi
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30. A. D. Roses
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31. P. E. Fraser
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32. J. M. Rommens
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33. P. H. St George-Hyslop
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Sherrington, R., Rogaev, E., Liang, Y. et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.Nature 375, 754–760 (1995). https://doi.org/10.1038/375754a0

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• Received: 17 May 1995
• Accepted: 07 June 1995
• Issue Date: 29 June 1995
• DOI: https://doi.org/10.1038/375754a0