Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene (original) (raw)

Nature volume 377, pages 351–354 (1995)Cite this article

Abstract

THE lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-12 / Notch family of receptors for intercellular signals that specify cell fate1,2. By screening for suppressors of a lin-12 gain-of-function mutation, we identified a new gene, sel-12, which appears to function in receiving cells to facilitate signalling mediated by lin-12 and glp-1. The sel-12 gene encodes a protein with multiple transmembrane domains, and is similar to S182, which has been implicated in early-onset familial Alzheimer's disease3. The high degree of sequence conservation suggests that the function of the SEL-12 and S182 proteins may also be conserved.

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Authors and Affiliations

  1. Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA
    Diane Levitan
  2. Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA
    Iva Greenwald

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  1. Diane Levitan
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  2. Iva Greenwald
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Levitan, D., Greenwald, I. Facilitation of _lin-12_-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene.Nature 377, 351–354 (1995). https://doi.org/10.1038/377351a0

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