Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice (original) (raw)
References
D'Arcangelo, G. et al. Aprotein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature374, 719–723 (1995). ArticleADSCAS Google Scholar
Rakic, P. & Caviness, V. S. J. Cortical development: view from neurological mutants two decades later. Neuron14, 1101–1104 (1995). Google Scholar
D'Arcangelo, G. et al. Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. J. Neurosci.17, 23–31 (1997). Google Scholar
Hirotsune, S. et al. The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons. Nature Genet.10, 77–83 (1995). Google Scholar
Ogawa, M. et al. The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Neuron14, 899–912 (1995). Google Scholar
Miyata, T. et al. Distribution of the reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogenic antibody CR-50 on normal and reeler mice. J. Comp. Neurol.372, 215–228 (1996). Google Scholar
Miyata, T., Nakajima, K., Mikoshiba, K. & Ogawa, M. Regulation of purkinje cell alignment by reelin as revealed with R-50 antibody. J. Neurosci.17, 3599–3609 (1997). Google Scholar
Sweet, H. O., Bronson, R. T., Johnson, K. R., Cook, S. A. & Davisson, M. T. Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration Mamm . Genome7, 798–802 (1996). Google Scholar
Yoneshima, H. et al. Anovel neurological mutation of mouse, yotari, which has reeler -like phenotype but expresses reelin. Neurosci. Res. (in the press).
Goldowitz, D. et al. Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin. J. Neurosci. (in the press).
Howell, B. W., Gertler, F. B. & Cooper, J. A. Mouse disabled (mDab1): a src binding protein implicated in neuronal development. EMBO J.16, 121–132 (1997). Google Scholar
Gertler, F. B., Bennett, R. L., Clark, M. J. & Hoffmann, F. M. Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axogenesis is revealed through dosage-sensitive interactions with disabled . Cell58, 103–113 (1989). Google Scholar
Howell, B. W., Hawkes, R., Soriano, P. & Cooper, J. A. Neuronal position in the developing brain is regulated by mouse disabled-1 . Nature389, 733–737 (1997). ArticleADSCAS Google Scholar
Tartaglia, L. A. Identification and expression cloning of a leptin receptor, OB-R. Cell83, 1263–1271 (1995). Google Scholar
Chua, S. C. J et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science271, 994–996 (1996). Google Scholar
Lee, G. H. et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature379, 632–635 (1996). ArticleADSCAS Google Scholar
Michaud, E. J. et al. Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage. Genes Dev.8, 1463–1472 (1994). Google Scholar
Rowe, L. B. et al. Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm. Genome5, 253–274 (1994). Google Scholar
Goffinet, A. M. Events governing organization of postmigratory neurons: studies on brain development in normal and reeler mice. Brain Res. Rev.7, 261–296 (1984). Google Scholar
Xu, X. X., Yang, W., Jackowski, S. & Rock, C. O. Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J. Biol. Chem.270, 14184–14191 (1995). Google Scholar
Zhou, M. M. et al. Structure and ligand recognition of the phosphotyrosine binding domain of Sch. Nature378, 584–592 (1995). ArticleADSCAS Google Scholar
Ohshima, T. et al. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl Acad. Sci. USA93, 11173–11178 (1996). Google Scholar
Chae, T. et al. Mice lacking p35, a neuronal activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron18, 29–42 (1997). Google Scholar
Tang, D. et al. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. J. Biol. Chem.270, 26897–26903 (1995). Google Scholar
Del Rio, J. A. et al. Arole for Cajal-Retzius cells and reelin in the development of hippocampal connections. Nature385, 70–74 (1997). ArticleADSCAS Google Scholar
Vaessin, H. et al. prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila . Cell67, 941–953 (1991). Google Scholar
Oliver, G. et al. Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech. Dev.44, 3–16 (1993). Google Scholar
Gertler, F. B. et al. enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. Genes Dev.9, 521–533 (1995). Google Scholar
Gertler, F. B., Niebuhr, K., Reinhard, M., Wehland, J. & Soriano, P. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell87, 227–239 (1996). Google Scholar
Dietrich, W. F. et al. Agenetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genet.7, 220–245 (1994). Google Scholar