DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters (original) (raw)
References
Issa, J.-P., Baylin, S.B. & Herman, J.G. DNA methylation changes in hematologic malignancies: biologic and clinical implications. Leukemia11, 7–11 (1997). Google Scholar
Jones, P.A. & Laird, P.W. Cancer epigenetics comes of age. Nature Genet.21, 163–166 (1999). ArticleCAS Google Scholar
Eden, S., Hashimshony, T., Keshet, I., Cedar, H. & Thorne, A.W. DNA methylation models histone acetylation. Nature394, 842 (1998). ArticleCAS Google Scholar
Jones, P.L. et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genet.19, 187–191 (1998). ArticleCAS Google Scholar
Nan, X. et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 invloves a histone deacetylase complex. Nature393, 386–389 (1998). ArticleCAS Google Scholar
Luff, B., Pawlowski, L. & Bender, J. An inverted repeat triggers cytosine methylation of identical sequences in Arabidopsis. Mol. Cell3, 505–511 (1999). ArticleCAS Google Scholar
Garrick, D., Fiering, S., Martin, D.I. & Whitelaw, E. Repeat-induced gene silencing in mammals. Nature Genet.18, 56–59 (1998). ArticleCAS Google Scholar
Hansen, R.S. et al. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc. Natl Acad. Sci. USA96, 14412–14417 (1999). ArticleCAS Google Scholar
Okano, M., Bell, D.W., Haber, D.A. & Li, W. DNA methyltransferases DNMT3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell99, 247–257 (1999). ArticleCAS Google Scholar
Xu, G.-L. et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature402, 187–191 (1999). ArticleCAS Google Scholar
Surani, M.A. Imprinting and the initiation of gene silencing in the germ line. Cell93, 309–312 (1998). ArticleCAS Google Scholar
Li, E., Bestor, T.H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell69, 915–926 (1992). ArticleCAS Google Scholar
Leonhardt, H., Page, A.W., Weier, H. & Bestor, T.H. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell71, 865–873 (1992). ArticleCAS Google Scholar
Fuks, F., Bergers, W.A., Brehm, A., Hughes-Davies, L. & Kouzarides, T. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nature Genet.24, 88–91 (2000). ArticleCAS Google Scholar
Dunaief, J.L. et al. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell79, 119–130 (1994). ArticleCAS Google Scholar
Chuang, L.S.-H. et al. Human DNA-(cytosine-5) methyltransferase-PCNA complex is a target for p21_Waf1_. Science277, 1996–2000 (1997). ArticleCAS Google Scholar
Grana, X., Garriga, J. & Mayol, X. Role of the retinoblastoma protein family, pRB, p107, and p130 in the negative control of cell growth. Oncogene17, 3365–3383 (1998). Article Google Scholar
Robertson, K.D. & Jones, P.A. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol. Cell. Biol18, 6457–6473 (1998). ArticleCAS Google Scholar
Luo, R.X., Postigo, A.A. & Dean, D.C. Rb interacts with histone deacetylase to repress transcription. Cell92, 463–473 (1998). ArticleCAS Google Scholar
Magnaghi-Jaulin, L. et al. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature391, 535–536 (1998). Article Google Scholar
Royzman, I., Austin, R.J., Bosco, G., Bell, S.P. & Orr-Weaver, T.L. ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Genes Dev. 13, 827–840 (1999). ArticleCAS Google Scholar
Sterner, J.M., Dew-Knight, S., Musahl, C., Kornbluth, S. & Horowitz, J.M. Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. Mol. Cell. Biol.18, 2748–2757 (1998). ArticleCAS Google Scholar
Hung, M.-S. et al. Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases. Proc. Natl Acad. Sci. USA96, 11940–11945 (1999). ArticleCAS Google Scholar
Issa, J.-P. et al. Increased DNA-methyltransferase activity during colon cancer progression. J. Natl Cancer Inst.85, 1235–1240 (1993). ArticleCAS Google Scholar
Smith, S.S., Kaplan, B.E., Sowers, L.C. & Newman, E.M. Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation. Proc. Natl Acad. Sci. USA89, 4744–4748 (1992). ArticleCAS Google Scholar
Robertson, K.D. et al. The human DNA methyltransferases (DNMTs) 1, 3a, and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res.27, 2291–2298 (1999). ArticleCAS Google Scholar
Ait-si-ali, S. et al. Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A. Nature396, 184–186 (1998). ArticleCAS Google Scholar
Meehan, R.R., Lewis, J.D., McKay, S., Kleiner, E.L. & Bird, A.P. Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell58, 499–507 (1989). ArticleCAS Google Scholar