Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres (original) (raw)
References
Broccoli, D., Smogorzewska, A., Chong, L. & de Lange, T. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genet.17, 231–235 (1997). ArticleCAS Google Scholar
Bilaud, T. et al. Telomeric localization of TRF2, a novel human telobox protein. Nature Genet.17, 236–239 (1997). ArticleCAS Google Scholar
van Steensel, B., Smogorzewska, A. & de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell92, 401–413 (1998). ArticleCAS Google Scholar
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S. & de Lange, T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science283, 1321–1325 (1999). ArticleCAS Google Scholar
Griffith, J.D. et al. Mammalian telomeres end in a large duplex loop. Cell97, 503–514 (1999). ArticleCAS Google Scholar
Wilm, M. et al. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature379, 466–469 (1996). ArticleCAS Google Scholar
Li, B., Oestreich, S. & de Lange, T. Identification of human Rap1: implications for telomere evolution. Cell101, 471–483 (2000). ArticleCAS Google Scholar
Dolganov, G.M. et al. Human Rad50 is physically associated with hMre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol. Cell. Biol.16, 4832–4841 (1996). ArticleCAS Google Scholar
Carney, J.P. et al. The hMre11/hRad50 protein complex and Nijmegen Breakage Syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell93, 477–486 (1998). ArticleCAS Google Scholar
Nelms, B.E., Maser, R.S., MacKay, J.F., Lagally, M.G. & Petrini, J.H.J. In situ visualization of DNA double-strand break repair in human fibroblasts. Science280, 590–592 (1998). ArticleCAS Google Scholar
Lim, D.-S. et al. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature404, 613–617 (2000). ArticleCAS Google Scholar
Bressan, D.A., Baxter, B.K. & Petrini, J.H.J. The Mre11/Rad50/Xrs2 protein complex facilitates homologous recombination-based double strand break repair in Saccharomyces cerevisiae. Mol. Cell. Biol. 19, 7681–7687 (1999). ArticleCAS Google Scholar
Usui, T., Ohta, T., Oshiumi, J., Ogawa, T.H. & Ogawa, T. Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell95, 705–716 (1998). ArticleCAS Google Scholar
Nugent, C. et al. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr. Biol.8, 657–660 (1998). ArticleCAS Google Scholar
Boulton, S.J. & Jackson, S.P. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J.17, 1819–1828 (1998). ArticleCAS Google Scholar
Le, S., Moore, J.K., Haber, J.E. & Greider, C.W. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics152, 143–152 (1999). CASPubMedPubMed Central Google Scholar
Xiao, Y. & Weaver, D.T. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res.25, 2985–2991 (1997). ArticleCAS Google Scholar
Luo, G. et al. Disruption of mRad50 causes ES cell lethality, abnormal embryonic development and sensitivity to ionizing radiation. Proc. Natl Acad. Sci. USA96, 7376–7381 (1999). ArticleCAS Google Scholar
van Steensel, B. & de Lange, T. Control of telomere length by the human telomeric protein TRF1. Nature385, 740–743 (1997). ArticleCAS Google Scholar
Maser, R.S., Monsen, K.J., Nelms, B. & Petrini, J.H.J. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol. Cell. Biol.17, 6087–6096 (1997). ArticleCAS Google Scholar
Bryan, T.M., Englezou, A., Gupta, J., Bacchetti, S. & Reddel, R.R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J.14, 4240–4248 (1995). ArticleCAS Google Scholar
Yeager, T.R. et al. Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res.59, 4175–4179 (1999). CASPubMed Google Scholar
Stewart, G. et al. The DNA double strand break repair gene hMre11, is mutated in individuals with a new ataxia telangiectasia like disorders (ATLD). Cell99, 577–587 (1999). ArticleCAS Google Scholar
Martin, S.G., Laroche, T., Suka, N., Grunstein, M. & Gasser, S.M. Relocalization of telomeric Ku and Sir proteins in response to DNA strand breaks in yeast. Cell97, 621–633 (1999). ArticleCAS Google Scholar
Mills, K.D., Sinclair, D.A. & Guarente, L. Mec1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell97, 609–620 (1999). ArticleCAS Google Scholar
Moore, J.K. & Haber, J.E. Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol. Cell. Biol.16, 2164–2173 (1996). ArticleCAS Google Scholar
Paull, T.T. & Gellert, M. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev.13, 1276–1288 (1999). ArticleCAS Google Scholar
Harley, C.B. Telomeres and aging. in Telomeres (eds Blackburn, E.H. & Greider, C.W.) 247–265 (Cold Spring Harbor Press, Cold Spring Harbor, New York, 1995). Google Scholar
Shevchenko, A., Wilm, M., Vorm, O. & Mann, M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem.68, 850–858 (1996). ArticleCAS Google Scholar
Shevchenko, A. et al. Rapid ‘de novo’ peptide sequencing by a combination of nanoelectrospray, isotopic labeling and a quadrupole/time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom.11, 1015–1024 (1997). ArticleCAS Google Scholar
Mann, M. & Wilm, M. Error-tolerant identification of peptides in sequence databases by peptide sequence tags. Anal. Chem.66, 4390–4399 (1994). ArticleCAS Google Scholar