Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions (original) (raw)

• Dvorak, H.F. VPF/VEGF and the angiogenic response. Semin. Perinatol. 24, 75–78 (2000).
  Article CAS Google Scholar
• Ferrara, N. Vascular endothelial growth factor: molecular and biological aspects. Curr. Top. Microbiol. Immunol. 237, 1–30 (1999).
  CAS PubMed Google Scholar
• Persico, M.G., Vincenti, V. & DiPalma, T. Structure, expression and receptor-binding properties of placenta growth factor (PlGF). Curr. Top. Microbiol. Immunol. 237, 31–40 (1999).
  CAS PubMed Google Scholar
• Achen, M.G., Gad, J.M., Stacker, S.A. & Wilks, A.F. Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development. Growth Factors 15, 69–80 (1997).
  Article CAS Google Scholar
• Monsky, W.L. et al. Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. Cancer Res. 59, 4129–4135 (1999).
  CAS PubMed Google Scholar
• Park, J.E., Chen, H.H., Winer, J., Houck, K.A. & Ferrara, N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem. 269, 25646–25654 (1994).
  CAS PubMed Google Scholar
• Viglietto, G. et al. Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor. Oncogene 13, 577–587 (1996).
  CAS PubMed Google Scholar
• Nomura, M. et al. Placenta growth factor (PlGF) mRNA expression in brain tumors. J. Neurooncol. 40, 123–30 (1998).
  Article CAS Google Scholar
• Neufeld, G., Cohen, T., Gengrinovitch, S. & Poltorak, Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13, 9–22 (1999).
  Article CAS Google Scholar
• Shibuya, M., Ito, N. & Claesson-Welsh, L. Structure and function of vascular endothelial growth factor receptor-1 and -2. Curr. Top. Microbiol. Immunol. 237, 59–83 (1999).
  CAS PubMed Google Scholar
• Fong, G.H., Rossant, J., Gertsenstein, M. & Breitman, M.L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376, 66–70 (1995).
  Article CAS Google Scholar
• Hiratsuka, S., Minowa, O., Kuno, J., Noda, T. & Shibuya, M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA 95, 9349–9354 (1998).
  Article CAS Google Scholar
• Kendall, R.L., Wang, G. & Thomas, K.A. Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem. Biophys. Res. Commun. 226, 324–328 (1996).
  Article CAS Google Scholar
• Clark, D.E. et al. A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation. Biol. Reprod. 59, 1540–1548 (1998).
  Article CAS Google Scholar
• Landgren, E., Schiller, P., Cao, Y. & Claesson-Welsh, L. Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-γ and migration of endothelial cells expressing Flt 1. Oncogene 16, 359–367 (1998).
  Article CAS Google Scholar
• Cao, Y., Linden, P., Shima, D., Browne, F. & Folkman, J. In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. J. Clin. Invest. 98, 2507–2511 (1996).
  Article CAS Google Scholar
• DiSalvo, J. et al. Purification and characterization of a naturally occurring vascular endothelial growth factor.placenta growth factor heterodimer. J. Biol. Chem. 270, 7717–7723 (1995).
  Article CAS Google Scholar
• Olofsson, B., Jeltsch, M., Eriksson, U. & Alitalo, K. Current biology of VEGF-B and VEGF-C. Curr. Opin. Biotechnol. 10, 528–535 (1999).
  Article CAS Google Scholar
• Aase, K. et al. VEGF-B deficient mice display an atrial conduction defect. Circulation (in the press).
• Hatva, E. et al. Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas. Am. J. Pathol. 148, 763–775 (1996).
  CAS PubMed PubMed Central Google Scholar
• Takahashi, A. et al. Identification of receptor genes in renal cell carcinoma associated with angiogenesis by differential hybridization technique. Biochem. Biophys. Res. Commun. 257, 855–859 (1999).
  Article CAS Google Scholar
• Viglietto, G. et al. Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines. Oncogene 11, 1569–1579 (1995).
  CAS PubMed Google Scholar
• Simpson, D.A. et al. Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia. Biochem. Biophys. Res. Commun. 262, 333–340 (1999).
  Article CAS Google Scholar
• Khaliq, A. et al. Increased expression of placenta growth factor in proliferative diabetic retinopathy. Lab. Invest. 78, 109–116 (1998).
  CAS PubMed Google Scholar
• Heymans, S. et al. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nature Med. 5, 1135–1142 (1999).
  Article CAS Google Scholar
• Arras, M. et al. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J. Clin. Invest. 101, 40–50 (1998).
  Article CAS Google Scholar
• Clauss, M. et al. The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J. Biol. Chem. 271, 17629–17634 (1996).
  Article CAS Google Scholar
• Rafii, S. Circulating endothelial precursors: mystery, reality, and promise. J. Clin. Invest. 105, 17–19 (2000).
  Article CAS Google Scholar
• Kalka, C. et al. Vascular endothelial growth factor (165) gene transfer augments circulating endothelial progenitor cells in human subjects. Circ. Res. 86, 1198–1202 (2000).
  Article CAS Google Scholar
• Eliceiri, B.P. et al. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol. Cell. 4, 915–924 (1999).
  Article CAS Google Scholar
• He, H. et al. Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c–Src. J. Biol. Chem. 274, 25130–25135 (1999).
  Article CAS Google Scholar
• Carmeliet, P. Mechanisms of angiogenesis and arteriogenesis. Nature Med. 6, 389–395 (2000).
  Article CAS Google Scholar
• Migdal, M. et al. Neuropilin-1 is a placenta growth factor-2 receptor. J. Biol. Chem. 273, 22272–22278 (1998).
  Article CAS Google Scholar
• Gerber, H.P. et al. VEGF is required for growth and survival in neonatal mice. Development 126, 1149–1159 (1999).
  CAS Google Scholar
• Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435–439 (1996).
  Article CAS Google Scholar
• Witte, L. et al. Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy. Cancer Metastasis Rev. 17, 155–161 (1998).
  Article CAS Google Scholar
• Carmeliet, P. et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 98, 147–157 (1999).
  Article CAS Google Scholar
• Carmeliet, P. et al. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nature Med. 5, 495–502 (1999).
  Article CAS Google Scholar
• Passaniti, A. et al. A simple, quantitative method for assessing aniogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab. Invest. 67, 519–528 (1992).
  CAS PubMed Google Scholar
• Carmeliet, P. et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394, 485–490 (1998).
  Article CAS Google Scholar
• Ryan, H.E. et al. Hypoxia-inducible factor-1α is a positive factor in solid tumor growth. Cancer Res. 60, 4010–4015 (2000).
  CAS Google Scholar
• Frank, S. et al. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J. Biol. Chem. 270, 12607–12613 (1995).
  Article CAS Google Scholar
• Thurston, G. et al. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nature Med. 6, 460–463 (2000).
  Article CAS Google Scholar
• Vicaut, E. & Stucker, O. An intact cremaster muscle preparation for studying the microcirculation by in vivo microscopy. Microvasc. Res. 39, 120–122 (1990).
  Article CAS Google Scholar
• Nicosia, R.F. & Villaschi, S. Autoregulation of angiogenesis by cells of the vessel wall. Int. Rev. Cytol. 185, 1–43 (1999).
  CAS PubMed Google Scholar