Tyrosine kinase inhibition in diffuse large B-cell lymphoma: molecular basis for antitumor activity and drug resistance of dasatinib (original) (raw)
Sehn LH . Optimal use of prognostic factors in non-Hodgkin lymphoma. Hematology (Am Soc Hematol Educ Program) 2006, 295–302. Article Google Scholar
Andrew T, Lister BC, Armitage JO . Non-Hodgkin's lymphoma. In: Martin D. Abeloff, James O. Armitage JEN, Michael B. Kastan, W. Gillies McKenna (eds). Clinical Oncology. (e 3rd edn) Churchill Livingstone: Philadelphia PA, 2004, pp 3015–3076. Google Scholar
De Paepe P, De Wolf-Peeters C . Diffuse large B-cell lymphoma: a heterogeneous group of non-Hodgkin lymphomas comprising several distinct clinicopathological entities. Leukemia 2007; 21: 37–43. ArticleCASPubMed Google Scholar
Abramson JS, Shipp MA . Advances in the biology and therapy of diffuse large B-cell lymphoma: moving toward a molecularly targeted approach. Blood 2005; 106: 1164–1174. ArticleCASPubMed Google Scholar
Kuppers R . Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005; 5: 251–262. ArticlePubMed Google Scholar
Rodriguez A, Villuendas R, Yanez L, Gomez ME, Diaz R, Pollan M et al. Molecular heterogeneity in chronic lymphocytic leukemia is dependent on BCR signaling: clinical correlation. Leukemia 2007; 21: 1984–1991. ArticleCASPubMed Google Scholar
Dal Porto JM, Gauld SB, Merrell KT, Mills D, Pugh-Bernard AE, Cambier J . B cell antigen receptor signaling 101. Mol Immunol 2004; 41: 599–613. ArticleCASPubMed Google Scholar
Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503–511. ArticleCASPubMed Google Scholar
Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 2002; 346: 1937–1947. ArticlePubMed Google Scholar
Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM . A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc Natl Acad Sci USA 2003; 100: 9991–9996. ArticleCASPubMedPubMed Central Google Scholar
Monti S, Savage KJ, Kutok JL, Feuerhake F, Kurtin P, Mihm M et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 2005; 105: 1851–1861. ArticleCASPubMed Google Scholar
Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC et al. Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med 2002; 8: 68–74. ArticleCASPubMed Google Scholar
Wang YL, Frauwirth KA, Rangwala SM, Lazar MA, Thompson CB . Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival. J Biol Chem 2002; 277: 31781–31788. ArticleCASPubMed Google Scholar
Anagostopoulos I, Dallenbach F, Stein H . Diffuse large cell lymphomas. In: Knowles DM (ed). Neoplastic Hematopathology, 2nd edn, Lippincott Williams &Wilkins: Philadelphia, PA, 2001, pp 855–913. Google Scholar
Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 2004; 103: 275–282. ArticleCASPubMed Google Scholar
Chang CC, McClintock S, Cleveland RP, Trzpuc T, Vesole DH, Logan B et al. Immunohistochemical expression patterns of germinal center and activation B-cell markers correlate with prognosis in diffuse large B-cell lymphoma. Am J Surg Pathol 2004; 28: 464–470. ArticlePubMed Google Scholar
Haarer CF, Roberts RA, Frutiger YM, Grogan TM, Rimsza LM . Immunohistochemical classification of de novo, transformed, and relapsed diffuse large B-cell lymphoma into germinal center B-cell and nongerminal center B-cell subtypes correlates with gene expression profile and patient survival. Arch Pathol Lab Med 2006; 130: 1819–1824. PubMed Google Scholar
Salazar EP, Rozengurt E . Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397. J Biol Chem 2001; 276: 17788–17795. ArticleCASPubMed Google Scholar
Contri A, Brunati AM, Trentin L, Cabrelle A, Miorin M, Cesaro L et al. Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis. J Clin Invest 2005; 115: 369–378. ArticleCASPubMedPubMed Central Google Scholar
Spreafico A SS, Serchi T, Orlandini M, Angelucci A, Magrini D, Bernardini G et al. Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]p yrimidine derivative Src kinase inhibitors in human osteosarcoma cells. FASEB J 2008 2008; 22: 1560–1571. ArticlePubMed Google Scholar
Nunoda K, Tauchi T, Takaku T, Okabe S, Akahane D, Sashida G et al. Identification and functional signature of genes regulated by structurally different ABL kinase inhibitors. Oncogene 2007; 26: 4179–4188. ArticleCASPubMed Google Scholar
Muris JJ, Cillessen SA, Vos W, van Houdt IS, Kummer JA, van Krieken JH et al. Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood 2005; 105: 2916–2923. ArticleCASPubMed Google Scholar
Muris JJ, Meijer CJ, Vos W, van Krieken JH, Jiwa NM, Ossenkoppele GJ et al. Immunohistochemical profiling based on Bcl-2, CD10 and MUM1 expression improves risk stratification in patients with primary nodal diffuse large B cell lymphoma. J Pathol 2006; 208: 714–723. ArticleCASPubMed Google Scholar
Duckett CS, Nava VE, Gedrich RW, Clem RJ, Van Dongen JL, Gilfillan MC et al. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J 1996; 15: 2685–2694. ArticleCASPubMedPubMed Central Google Scholar
Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G et al. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 1996; 379: 349–353. ArticleCASPubMed Google Scholar
Irish JM, Czerwinski DK, Nolan GP, Levy R . Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry. J Immunol 2006; 177: 1581–1589. ArticleCASPubMed Google Scholar
Johnson FM, Saigal B, Talpaz M, Donato NJ . Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells. Clin Cancer Res 2005; 11: 6924–6932. ArticleCASPubMed Google Scholar
Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY et al. Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 2006; 66: 473–481. ArticleCASPubMed Google Scholar
Serrels A, Macpherson IR, Evans TR, Lee FY, Clark EA, Sansom OJ et al. Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Mol Cancer Ther 2006; 5: 3014–3022. ArticleCASPubMed Google Scholar
Tsao AS, He D, Saigal B, Liu S, Lee JJ, Bakkannagari S et al. Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration and invasion. Mol Cancer Ther 2007; 6: 1962–1972. ArticleCASPubMed Google Scholar
Finn RS, Dering J, Ginther C, Wilson CA, Glaspy P, Tchekmedyian N et al. Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/‘triple-negative’ breast cancer cell lines growing in vitro . Breast Cancer Res Treat 2007; 105: 319–326. ArticleCASPubMed Google Scholar
Quintas-Cardama A, Kantarjian H, O’Brien S, Borthakur G, Bruzzi J, Munden R et al. Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure. J Clin Oncol 2007; 25: 3908–3914. ArticleCASPubMed Google Scholar
Carter TA, Wodicka LM, Shah NP, Velasco AM, Fabian MA, Treiber DK et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci USA 2005; 102: 11011–11016. ArticleCASPubMedPubMed Central Google Scholar
Sprangers M, Feldhahn N, Herzog S, Hansmann ML, Reppel M, Hescheler J et al. The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells. Oncogene 2006; 25: 5056–5062. ArticleCASPubMed Google Scholar