POT1 as a terminal transducer of TRF1 telomere length control (original) (raw)

References

  1. Blackburn, E. H. Telomere states and cell fates. Nature 408, 53–56 (2000)
    Article ADS CAS Google Scholar
  2. de Lange, T. Protection of mammalian telomeres. Oncogene 21, 532–540 (2002)
    Article CAS Google Scholar
  3. Granger, M. P., Wright, W. E. & Shay, J. W. Telomerase in cancer and aging. Crit. Rev. Oncol. Hematol. 41, 29–40 (2002)
    Article Google Scholar
  4. Maser, R. S. & DePinho, R. A. Connecting chromosomes, crisis, and cancer. Science 297, 565–569 (2002)
    Article ADS CAS Google Scholar
  5. van Steensel, B. & de Lange, T. Control of telomere length by the human telomeric protein TRF1. Nature 385, 740–743 (1997)
    Article ADS CAS Google Scholar
  6. Smogorzewska, A. et al. Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 20, 1659–1668 (2000)
    Article CAS Google Scholar
  7. Smith, S. & de Lange, T. Tankyrase promotes telomere elongation in human cells. Curr. Biol. 10, 1299–1302 (2000)
    Article CAS Google Scholar
  8. Kim, S. H., Kaminker, P. & Campisi, J. TIN2, a new regulator of telomere length in human cells. Nature Genet. 23, 405–412 (1999)
    Article CAS Google Scholar
  9. Zhou, X. Z. & Lu, K. P. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107, 347–359 (2001)
    Article CAS Google Scholar
  10. Ancelin, K. et al. Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol. Cell. Biol. 22, 3474–3487 (2002)
    Article CAS Google Scholar
  11. Barnett, M. A. et al. Telomere directed fragmentation of mammalian chromosomes. Nucleic Acids Res. 21, 27–36 (1993)
    Article CAS Google Scholar
  12. Hanish, J. P., Yanowitz, J. L. & de Lange, T. Stringent sequence requirements for the formation of human telomeres. Proc. Natl Acad. Sci. USA 91, 8861–8865 (1994)
    Article ADS CAS Google Scholar
  13. Sprung, C. N., Reynolds, G. E., Jasin, M. & Murnane, J. P. Chromosome healing in mouse embryonic stem cells. Proc. Natl Acad. Sci. USA 96, 6781–6786 (1999)
    Article ADS CAS Google Scholar
  14. Sprung, C. N., Sabatier, L. & Murnane, J. P. Telomere dynamics in a human cancer cell line. Exp. Cell Res. 247, 29–37 (1999)
    Article CAS Google Scholar
  15. Marcand, S., Gilson, E. & Shore, D. A protein-counting mechanism for telomere length regulation in yeast. Science 275, 986–990 (1997)
    Article CAS Google Scholar
  16. Evans, S. K. & Lundblad, V. Positive and negative regulation of telomerase access to the telomere. J. Cell Sci. 113, 3357–3364 (2000)
    CAS PubMed Google Scholar
  17. Baumann, P. & Cech, T. R. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292, 1171–1175 (2001)
    Article ADS CAS Google Scholar
  18. Baumann, P., Podell, E. & Cech, T. R. Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Mol. Cell. Biol. 22, 8079–8087 (2002)
    Article CAS Google Scholar
  19. de Lange, T. Telomere capping—one strand fits all. Science 292, 1075–1076 (2001)
    Article CAS Google Scholar
  20. Mitton-Fry, R. M., Anderson, E. M., Hughes, T. R., Lundblad, V. & Wuttke, D. S. Conserved structure for single-stranded telomeric DNA recognition. Science 296, 145–147 (2002)
    Article ADS CAS Google Scholar
  21. van Steensel, B., Smogorzewska, A. & de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401–413 (1998)
    Article CAS Google Scholar
  22. Li, B., Oestreich, S. & de Lange, T. Identification of human Rap1: implications for telomere evolution. Cell 101, 471–483 (2000)
    Article CAS Google Scholar
  23. Zhu, X. D., Kuster, B., Mann, M., Petrini, J. H. & Lange, T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nature Genet. 25, 347–352 (2000)
    Article CAS Google Scholar
  24. Smith, S., Giriat, I., Schmitt, A. & de Lange, T. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282, 1484–1487 (1998)
    Article CAS Google Scholar
  25. Cook, B. D., Dynek, J. N., Chang, W., Shostak, G. & Smith, S. Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol. Cell. Biol. 22, 332–342 (2002)
    Article CAS Google Scholar
  26. Griffith, J. D. et al. Mammalian telomeres end in a large duplex loop. Cell 97, 503–514 (1999)
    Article CAS Google Scholar
  27. Lei, M., Baumann, P. & Cech, T. R. Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry 41, 14560–14568 (2002)
    Article CAS Google Scholar
  28. Karlseder, J., Smogorzewska, A. & de Lange, T. Senescence induced by altered telomere state, not telomere loss. Science 295, 2446–2449 (2002)
    Article ADS CAS Google Scholar
  29. de Lange, T. et al. Structure and variability of human chromosome ends. Mol. Cell. Biol. 10, 518–527 (1990)
    Article CAS Google Scholar

Download references