CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members (original) (raw)
Bignell, G. R. et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nature Genet.25, 160–165 (2000) ArticleCAS Google Scholar
Ghosh, S. & Karin, M. Missing pieces in the NF-κB puzzle. Cell109, S81–S96 (2002) ArticleCAS Google Scholar
Jain, A. et al. Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia. Nature Immunol.2, 223–228 (2001) ArticleCAS Google Scholar
Wilkinson, K. D. Regulation of ubiquitin-dependent processes by deubiquitinating enzymes. FASEB J.11, 1245–1256 (1997) ArticleCAS Google Scholar
Headon, D. J. & Overbeek, P. A. Involvement of a novel TNF receptor homologue in hair follicle induction. Nature Genet.22, 370–374 (1999) ArticleCAS Google Scholar
Yan, M. et al. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science290, 523–527 (2000) ArticleADSCAS Google Scholar
Hatzivassiliou, E. & Mosialos, G. Cellular signaling pathways engaged by the Epstein-Barr virus transforming protein LMP1. Front. Biosci.7, d319–d329 (2002) ArticleCAS Google Scholar
Nguyen, L. T. et al. TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses. Immunity11, 379–389 (1999) ArticleCAS Google Scholar
Lomaga, M. A. et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev.13, 1015–1024 (1999) ArticleCAS Google Scholar
Yan, M. et al. Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice. Curr. Biol.12, 409–413 (2002) ArticleCAS Google Scholar
Naito, A. et al. TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. Proc. Natl Acad. Sci. USA99, 8766–8771 (2002) ArticleADSCAS Google Scholar
Kaye, K. M. et al. Tumor necrosis factor receptor associated factor 2 is a mediator of NF-κB activation by latent infection membrane protein 1, the Epstein–Barr virus transforming protein. Proc. Natl Acad. Sci. USA93, 11085–11090 (1996) ArticleADSCAS Google Scholar
Schultheiss, U. et al. TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1. EMBO J.20, 5678–5691 (2001) ArticleCAS Google Scholar
Deng, L. et al. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell103, 351–361 (2000) ArticleCAS Google Scholar
Wang, C. et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature412, 346–351 (2001) ArticleADSCAS Google Scholar
Shi, C. S. & Kehrl, J. H. Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). J. Biol. Chem.278, 15429–15434 (2003) ArticleCAS Google Scholar
McKenna, S. et al. An NMR-based model of the ubiquitin-bound human ubiquitin conjugation complex Mms2-Ubc13. The structural basis for lysine 63 chain catalysis. J. Biol. Chem.278, 13151–13158 (2003) ArticleCAS Google Scholar
Devin, A. et al. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity12, 419–429 (2000) ArticleCAS Google Scholar
Devin, A. et al. The α and β subunits of IκB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Mol. Cell. Biol.21, 3986–3994 (2001) ArticleCAS Google Scholar
Zhang, S. Q., Kovalenko, A., Cantarella, G. & Wallach, D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKγ) upon receptor stimulation. Immunity12, 301–311 (2000) ArticleCAS Google Scholar
Hu, M. et al. Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell111, 1041–1054 (2002) ArticleCAS Google Scholar
Karin, M., Cao, Y., Greten, F. R. & Li, Z. W. NF-κB in cancer: from innocent bystander to major culprit. Nature Rev. Cancer2, 301–310 (2002) ArticleCAS Google Scholar
Brummelkamp, T. R., Nijman, S. M. B., Dirac, A. M. G. & Bernards, R. Loss of cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature424, 797–801 (2003) ArticleADSCAS Google Scholar
Mosialos, G. et al. The Epstein–Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell80, 389–399 (1995) ArticleCAS Google Scholar
Mitchell, T. & Sugden, B. Stimulation of NF-κB-mediated transcription by mutant derivatives of the latent membrane protein of Epstein–Barr virus. J. Virol.69, 2968–2976 (1995) CASPubMedPubMed Central Google Scholar
Hatzivassiliou, E., Cardot, P., Zannis, V. I. & Mitsialis, S. A. Ultraspiracle, a Drosophila retinoic X receptor α homologue, can mobilize the human thyroid hormone receptor to transactivate a human promoter. Biochemistry36, 9221–9231 (1997) ArticleCAS Google Scholar
Devergne, O. et al. Association of TRAF1, TRAF2, and TRAF3 with an Epstein–Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF- κB activation. Mol. Cell. Biol.16, 7098–7108 (1996) ArticleCAS Google Scholar