A role for the immunological synapse in lineage commitment of CD4 lymphocytes (original) (raw)

• Huppa, J. B. & Davis, M. M. T-cell-antigen recognition and the immunological synapse. Nature Rev. Immunol. 3, 973–983 (2003)
  Article CAS Google Scholar
• Grakoui, A. et al. The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221–227 (1999)
  Article CAS Google Scholar
• Bromley, S. K. et al. The immunological synapse. Annu. Rev. Immunol. 19, 375–396 (2001)
  Article CAS Google Scholar
• Viola, A., Schroeder, S., Sakakibara, Y. & Lanzavecchia, A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283, 680–682 (1999)
  Article ADS CAS Google Scholar
• Balamuth, F., Leitenberg, D., Unternaehrer, J., Mellman, I. & Bottomly, K. Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells. Immunity 15, 729–738 (2001)
  Article CAS Google Scholar
• Madrenas, J. A SLAT in the Th2 signalosome. Immunity 18, 459–461 (2003)
  Article CAS Google Scholar
• Szabo, S. J., Sullivan, B. M., Peng, S. L. & Glimcher, L. H. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21, 713–758 (2003)
  Article CAS Google Scholar
• O'Garra, A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8, 275–283 (1998)
  Article CAS Google Scholar
• Murphy, K. M. & Reiner, S. L. The lineage decisions of helper T cells. Nature Rev. Immunol. 2, 933–944 (2002)
  Article CAS Google Scholar
• Miller, M. J., Wei, S. H., Parker, I. & Cahalan, M. D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296, 1869–1873 (2002)
  Article ADS CAS Google Scholar
• Vereb, G. et al. Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts. Proc. Natl Acad. Sci. USA 97, 6013–6018 (2000)
  Article ADS CAS Google Scholar
• Zhu, J., Cote-Sierra, J., Guo, L. & Paul, W. E. Stat5 activation plays a critical role in Th2 differentiation. Immunity 19, 739–748 (2003)
  Article CAS Google Scholar
• Takaoka, A. et al. Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains. Science 288, 2357–2360 (2000)
  Article ADS CAS Google Scholar
• Fowell, D. J. & Locksley, R. M. Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases. Bioessays 21, 510–518 (1999)
  Article CAS Google Scholar
• Watzl, C. & Long, E. O. Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts. J. Exp. Med. 197, 77–85 (2003)
  Article CAS Google Scholar
• Chen, C. H. et al. Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation. J. Exp. Med. 197, 1689–1699 (2003)
  Article CAS Google Scholar
• Lee, K. H. et al. T cell receptor signaling precedes immunological synapse formation. Science 295, 1539–1542 (2002)
  Article ADS CAS Google Scholar
• Huppa, J. B., Gleimer, M., Sumen, C. & Davis, M. M. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nature Immunol. 4, 749–755 (2003)
  Article CAS Google Scholar
• Lee, K. H. et al. The immunological synapse balances T cell receptor signaling and degradation. Science 302, 1218–1222 (2003)
  Article ADS CAS Google Scholar
• Poo, W. J., Conrad, L. & Janeway, C. A. Receptor-directed focusing of lymphokine release by helper T cells. Nature 332, 378–380 (1988)
  Article ADS CAS Google Scholar
• Trambas, C. M. & Griffiths, G. M. Delivering the kiss of death. Nature Immunol. 4, 399–403 (2003)
  Article CAS Google Scholar
• Reichert, P., Reinhardt, R. L., Ingulli, E. & Jenkins, M. K. Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells. J. Immunol. 166, 4278–4281 (2001)
  Article CAS Google Scholar
• Granucci, F. et al. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nature Immunol. 2, 882–888 (2001)
  Article CAS Google Scholar
• Welte, T. et al. STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation. Science 283, 222–225 (1999)
  Article CAS Google Scholar
• Gamero, A. M. & Larner, A. C. Signaling via the T cell antigen receptor induces phosphorylation of Stat1 on serine 727. J. Biol. Chem. 275, 16574–16578 (2000)
  Article CAS Google Scholar
• Zhu, J. et al. Transient inhibition of interleukin 4 signaling by T cell receptor ligation. J. Exp. Med. 192, 1125–1134 (2000)
  Article CAS Google Scholar
• Zhang, Y. et al. Interferon gamma stabilizes the T helper cell type 1 phenotype. J. Exp. Med. 194, 165–172 (2001)
  Article CAS Google Scholar
• Launois, P. et al. IL-4 rapidly produced by Vβ4 Vα8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity 6, 541–549 (1997)
  Article CAS Google Scholar
• Manes, S. et al. Membrane raft microdomains in chemokine receptor function. Semin. Immunol. 13, 147–157 (2001)
  Article CAS Google Scholar
• Tsui-Pierchala, B. A., Encinas, M., Milbrandt, J. & Johnson, E. M. Jr Lipid rafts in neuronal signaling and function. Trends Neurosci. 25, 412–417 (2002)
  Article CAS Google Scholar