A recurrent mutation in PALB2 in Finnish cancer families (original) (raw)

Change history

• 15 March 2007

In the AOP version of this Letter, an incorrect version of Figure 1 was published online on 7 February 2007, with errors in panel 1b. This Figure has now been corrected for both print and online publication on 15 March 2007

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Acknowledgements

We thank J. Ignatius, E. Nieminen, K. Mononen, H. Konola, O. Kajula, M. Vahera, K. Holli, T. Tammela, K. Rouhento, L. Enroth, R. Vaalavuo and S. Marttinen for help in sample and data collection and technical assistance. We also thank the Finnish Red Cross Blood Service for help with collection of population control blood samples, the Finnish Cancer Registry for information on cancer occurrence, and all patients and their family members for volunteering to participate in these studies. This study was supported by the Foundation for the Finnish Cancer Institute, the Academy of Finland, the Ida Montin Foundation, the Cancer Foundation of Northern Finland, the University of Oulu, Oulu University Hospital, the Reino Lahtikari Foundation, the Sigrid Juselius Foundation, Competitive Research Funding of the Pirkanmaa Hospital District, and grants to D.M.L. from the National Cancer Institute. This work was also supported by a grant from the Shapiro Family Foundation. D.M.L. is a scientific consultant to and a grant recipient of The Novartis Institute for Biomedical Research.

Author information

Author notes

1. Daphne W. Bell
   Present address: Present address: National Human Genome Research Institute/NIH, Bethesda, Maryland 20892, USA.,
2. Hannele Erkko and Bing Xia: These authors contributed equally to the work.

Authors and Affiliations

1. Department of Clinical Genetics,,
   Hannele Erkko, Jenni Nikkilä, Katri Pylkäs, Sanna-Maria Karppinen, Katrin Rapakko, Mervi Reiman, Aki Mustonen & Robert Winqvist
2. Department of Surgery,,
   Mervi Grip
3. Department of Oncology,,
   Arja Jukkola-Vuorinen
4. Department of Pathology, University of Oulu and Oulu University Hospital, FIN-90029 OYS, Finland,
   Ylermi Soini
5. Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA,
   Bing Xia, Alexander Miron, Qing Sheng, Guilan Li, Ronny I. Drapkin & David M. Livingston
6. Laboratory of Cancer Genetics, Institute of Medical Technology, FIN-33520 University of Tampere and Tampere University Hospital, Finland,
   Johanna Schleutker, Kirsi Syrjäkoski, Anne Kallioniemi & Henna Mattila
7. University of Kuopio and Department of Clinical Pathology, Institute of Clinical Medicine, Pathology and Forensic Medicine, Kuopio University Hospital, FIN-70211 Kuopio, Finland,
   Arto Mannermaa & Veli-Matti Kosma
8. Cancer Center and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA,
   Daphne W. Bell & Daniel A. Haber
9. Department of Medical Genetics, University of Helsinki and Biomedicum Helsinki, FIN-00014 HY, Finland,
   Juha Kere & Lauri A. Aaltonen
10. Department of Biosciences and Nutrition, and Clinical Research Centre, Karolinska Institutet, SE-17177 Huddinge, Sweden,
    Juha Kere
11. University of Kuopio and Department of Oncology, Institute of Clinical Medicine, Oncology, Kuopio University Hospital, FIN-70211 Kuopio, Finland,
    Vesa Kataja

Authors

1. Hannele Erkko
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2. Bing Xia
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3. Jenni Nikkilä
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4. Johanna Schleutker
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5. Kirsi Syrjäkoski
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6. Arto Mannermaa
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7. Anne Kallioniemi
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8. Katri Pylkäs
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9. Sanna-Maria Karppinen
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10. Katrin Rapakko
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11. Alexander Miron
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12. Qing Sheng
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13. Guilan Li
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14. Henna Mattila
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15. Daphne W. Bell
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16. Daniel A. Haber
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17. Mervi Grip
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18. Mervi Reiman
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19. Arja Jukkola-Vuorinen
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20. Aki Mustonen
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21. Juha Kere
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22. Lauri A. Aaltonen
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23. Veli-Matti Kosma
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24. Vesa Kataja
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25. Ylermi Soini
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26. Ronny I. Drapkin
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27. David M. Livingston
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28. Robert Winqvist
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Corresponding authors

Correspondence toDavid M. Livingston or Robert Winqvist.

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Supplementary information

Supplementary Information

This file contains Supplementary Methods, Supplementary Tables 1-2 and additional references. (PDF 267 kb)

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Erkko, H., Xia, B., Nikkilä, J. et al. A recurrent mutation in PALB2 in Finnish cancer families.Nature 446, 316–319 (2007). https://doi.org/10.1038/nature05609

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• Received: 05 December 2006
• Accepted: 19 January 2007
• Published: 07 February 2007
• Issue Date: 15 March 2007
• DOI: https://doi.org/10.1038/nature05609