Takeda, K., Kaisho, T. & Akira, S. Toll-like receptors. Annu. Rev. Immunol.21, 335–376 (2003) ArticleCAS Google Scholar
Nieuwdorp, M., Stroes, E. S., Meijers, J. C. & Buller, H. Hypercoagulability in the metabolic syndrome. Curr. Opin. Pharmacol.5, 155–159 (2005) ArticleCAS Google Scholar
Karin, M., Lawrence, T. & Nizet, V. Innate immunity gone awry: Linking microbial infections to chronic inflammation and cancer. Cell124, 823–835 (2006) ArticleCAS Google Scholar
Liew, F. Y., Xu, D., Brint, E. K. & O’Neill, L. A. Negative regulation of toll-like receptor-mediated immune responses. Nature Rev. Immunol.5, 446–458 (2005) ArticleCAS Google Scholar
Beeson, P. B. Tolerance to bacterial pyrogens I: Factors influencing its development. J. Exp. Med.86, 29–38 (1947) ArticleCAS Google Scholar
Beeson, P. B. Tolerance to bacterial pyrogens II: Role of the reticulo-endothelial system. J. Exp. Med.86, 39–44 (1947) ArticleCAS Google Scholar
West, M. A. & Heagy, W. Endotoxin tolerance: A review. Crit. Care Med.30, S64–S73 (2002) ArticleCAS Google Scholar
Cavaillon, J. M. & Adib-Conquy, M. Bench to bedside review: Endotoxin tolerance as a model of leukocyte reprogramming in sepsis. Crit. Care10, 1–8 (2006) Article Google Scholar
Dobrovolskaia, M. A. & Vogel, S. N. Toll receptors, CD14, and macrophage activation and deactivation by LPS. Microbes Infect.4, 903–914 (2002) ArticleCAS Google Scholar
Fujihara, M. et al. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol. Ther.100, 171–194 (2003) ArticleCAS Google Scholar
Medvedev, A. E., Kopydlowski, K. M. & Vogel, S. N. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: Dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression. J. Immunol.164, 5564–5574 (2000) ArticleCAS Google Scholar
Medvedev, A. E., Lentschat, A., Wahl, L. M., Golenbock, D. T. & Vogel, S. N. Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J. Immunol.169, 5209–5216 (2002) Article Google Scholar
Fujihara, M. et al. Lipopolysaccharide-triggered desensitization of TNF-α mRNA expression involves lack of phosphorylation of IκBα in a murine macrophage-like cell line, P388D1. J. Leukoc. Biol.68, 267–276 (2000) CASPubMed Google Scholar
Dobrovolskaia, M. A. et al. Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: Effects of TLR “homotolerance” versus “heterotolerance” on NF-κ B signaling pathway components. J. Immunol.170, 508–519 (2003) ArticleCAS Google Scholar
Huang, Q. et al. The plasticity of dendritic cell responses to pathogens and their components. Science294, 870–875 (2001) ArticleADSCAS Google Scholar
Ogawa, S. et al. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell122, 707–721 (2005) ArticleCAS Google Scholar
De Bosscher, K., Vanden Berghe, W. & Haegeman, G. The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: Molecular mechanisms for gene repression. Endocr. Rev.24, 488–522 (2003) ArticleCAS Google Scholar
Narlikar, G. J., Fan, H. Y. & Kingston, R. E. Cooperation between complexes that regulate chromatin structure and transcription. Cell108, 475–487 (2002) ArticleCAS Google Scholar
Chi, T. A BAF-centred view of the immune system. Nature Rev. Immunol.4, 965–977 (2004) ArticleCAS Google Scholar
Strahl, B. D. & Allis, C. D. The language of covalent histone modifications. Nature403, 41–45 (2000) ArticleADSCAS Google Scholar
Jenuwein, T. & Allis, C. D. Translating the histone code. Science293, 1074–1080 (2001) ArticleCAS Google Scholar
Kurdistani, S. K. & Grunstein, M. Histone acetylation and deacetylation in yeast. Nature Rev. Mol. Cell Biol.4, 276–284 (2003) ArticleCAS Google Scholar
Leoni, F. et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol. Med.11, 1–15 (2005) ArticleCAS Google Scholar
Nusinzon, I. & Horvath, C. M. Unexpected roles for deacetylation in interferon- and cytokine-induced transcription. J. Interferon Cytokine Res.25, 745–748 (2005) ArticleCAS Google Scholar
Santos-Rosa, H. et al. Active genes are tri-methylated at K4 of histone H3. Nature419, 407–411 (2002) ArticleADSCAS Google Scholar
Schneider, R. et al. Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nature Cell Biol.6, 73–77 (2004) ArticleCAS Google Scholar
Pokholok, D. K. et al. Genome-wide map of nucleosome acetylation and methylation in yeast. Cell122, 517–527 (2005) ArticleCAS Google Scholar
Bernstein, B. E. et al. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell120, 169–181 (2005) ArticleCAS Google Scholar
Metzger, E. et al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature437, 436–439 (2005) ArticleADSCAS Google Scholar
Ramirez-Carrozzi, V. R. et al. Selective and antagonistic functions of SWI/SNF and Mi-2β nucleosome remodeling complexes during an inflammatory response. Genes Dev.20, 282–296 (2006) ArticleCAS Google Scholar
Kaufmann, A., Gemsa, D. & Sprenger, H. Differential desensitization of lipopolysaccharide-inducible chemokine gene expression in human monocytes and macrophages. Eur. J. Immunol.30, 1562–1567 (2000) ArticleCAS Google Scholar
Learn, C. A., Mizel, S. B. & McCall, C. E. mRNA and protein stability regulate the differential expression of pro- and anti-inflammatory genes in endotoxin-tolerant THP-1 cells. J. Biol. Chem.275, 12185–12193 (2000) ArticleCAS Google Scholar
Henricson, B. E., Manthey, C. L., Perera, P. Y., Hamilton, T. A. & Vogel, S. N. Dissociation of lipopolysaccharide (LPS)-inducible gene expression in murine macrophages pretreated with smooth LPS versus monophosphoryl lipid A. Infect. Immun.61, 2325–2333 (1993) CASPubMedPubMed Central Google Scholar
Shnyra, A., Brewington, R., Alipio, A., Amura, C. & Morrison, D. C. Reprogramming of lipopolysaccharide-primed macrophages is controlled by a counterbalanced production of IL-10 and IL-12. J. Immunol.160, 3729–3736 (1998) CASPubMed Google Scholar
Flohe, S. et al. Endotoxin tolerance in rats: Expression of TNF-α, IL-6, IL-10, VCAM-1 and HSP 70 in lung and liver during endotoxin shock. Cytokine11, 796–804 (1999) ArticleCAS Google Scholar
Smale, S. T. The establishment and maintenance of lymphocyte identity through gene silencing. Nature Immunol.4, 607–615 (2003) ArticleCAS Google Scholar