E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8 (original) (raw)
Firestein, R. et al. CDK8 is a colorectal cancer oncogene that regulates β-catenin activity. Nature 10.1038/nature07179 (this issue)
Morris, E. J. et al. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo . PLoS Genet2, e196 (2006) Article Google Scholar
Freeman, M. & Bienz, M. EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye. EMBO Rep.2, 157–162 (2001) ArticleCAS Google Scholar
Clevers, H. Wnt/β-catenin signaling in development and disease. Cell127, 469–480 (2006) ArticleCAS Google Scholar
Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell87, 159–170 (1996) ArticleCAS Google Scholar
Morin, P. J. et al. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science275, 1787–1790 (1997) ArticleCAS Google Scholar
Hallstrom, T. C. & Nevins, J. R. Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proc. Natl Acad. Sci. USA100, 10848–10853 (2003) ArticleADSCAS Google Scholar
Black, E. P., Hallstrom, T., Dressman, H. K., West, M. & Nevins, J. R. Distinctions in the specificity of E2F function revealed by gene expression signatures. Proc. Natl Acad. Sci. USA102, 15948–15953 (2005) ArticleADSCAS Google Scholar
Sadot, E., Geiger, B., Oren, M. & Ben-Ze’ev, A. Down-regulation of β-catenin by activated p53. Mol. Cell. Biol.21, 6768–6781 (2001) ArticleCAS Google Scholar
Rother, K. et al. Identification of Tcf-4 as a transcriptional target of p53 signalling. Oncogene23, 3376–3384 (2004) ArticleCAS Google Scholar
Ueda, Y. et al. p73β, a variant of p73, enhances Wnt/β-catenin signaling in Saos-2 cells. Biochem. Biophys. Res. Commun.283, 327–333 (2001) ArticleCAS Google Scholar
Sansom, O. J. et al. Myc deletion rescues Apc deficiency in the small intestine. Nature446, 676–679 (2007) ArticleADSCAS Google Scholar
Liu, J. et al. Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol. Cell7, 927–936 (2001) ArticleCAS Google Scholar
Matsuzawa, S. I. & Reed, J. C. Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses. Mol. Cell7, 915–926 (2001) ArticleCAS Google Scholar
Hughes, T. A. & Brady, H. J. E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation. Biochem. Biophys. Res. Commun.329, 1267–1274 (2005) ArticleCAS Google Scholar
Hallstrom, T. C., Mori, S. & Nevins, J. R. An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell13, 11–22 (2008) ArticleCAS Google Scholar
Gope, R. et al. Increased expression of the retinoblastoma gene in human colorectal carcinomas relative to normal colonic mucosa. J. Natl Cancer Inst.82, 310–314 (1990) ArticleCAS Google Scholar
Kucherlapati, M. H., Nguyen, A. A., Bronson, R. T. & Kucherlapati, R. S. Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract. Cancer Res.66, 3576–3583 (2006) ArticleCAS Google Scholar
Haigis, K., Sage, J., Glickman, J., Shafer, S. & Jacks, T. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. J. Biol. Chem.281, 638–647 (2006) ArticleCAS Google Scholar
Williams, J. P. et al. The retinoblastoma protein is required for Ras-induced oncogenic transformation. Mol. Cell. Biol.26, 1170–1182 (2006) ArticleCAS Google Scholar
Dickins, R. A. et al. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nature Genet.37, 1289–1295 (2005) ArticleCAS Google Scholar
Faux, M. C. et al. Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion. J. Cell Sci.117, 427–439 (2004) ArticleCAS Google Scholar
Kim, S., Xu, X., Hecht, A. & Boyer, T. G. Mediator is a transducer of Wnt/β-catenin signaling. J. Biol. Chem.281, 14066–14075 (2006) ArticleCAS Google Scholar
Malik, S. & Roeder, R. G. Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem. Sci.30, 256–263 (2005) ArticleCAS Google Scholar
He, L. et al. A microRNA polycistron as a potential human oncogene. Nature435, 828–833 (2005) ArticleADSCAS Google Scholar
O'Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V. & Mendell, J. T. c-Myc-regulated microRNAs modulate E2F1 expression. Nature435, 839–843 (2005) ArticleADSCAS Google Scholar
Lee, Y. S. & Carthew, R. W. Making a better RNAi vector for Drosophila: use of intron spacers. Methods30, 322–329 (2003) ArticleCAS Google Scholar
Dick, F. A., Sailhamer, E. & Dyson, N. J. Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins. Mol. Cell. Biol.20, 3715–3727 (2000) ArticleCAS Google Scholar
Di Stefano, L., Jensen, M. R. & Helin, K. E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J.22, 6289–6298 (2003) ArticleCAS Google Scholar
Hurford, R. K., Cobrinik, D., Lee, M. H. & Dyson, N. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev.11, 1447–1463 (1997) ArticleCAS Google Scholar