Germline-encoded amino acids in the αβ T-cell receptor control thymic selection (original) (raw)
References
Zinkernagel, R. M. & Doherty, P. C. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature248, 701–702 (1974) ArticleADSCAS Google Scholar
Bevan, M. J. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature269, 417–418 (1977) ArticleADSCAS Google Scholar
Fink, P. J. & Bevan, M. J. H-2 antigens of the thymus determine lymphocyte specificity. J. Exp. Med.148, 766–775 (1978) ArticleCAS Google Scholar
Zinkernagel, R. M. et al. On the thymus in the differentiation of “H-2 self-recognition” by T cells: evidence for dual recognition? J. Exp. Med.147, 882–896 (1978) ArticleCAS Google Scholar
Kisielow, P., Teh, H. S., Bluthmann, H. & von Boehmer, H. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature335, 730–733 (1988) ArticleADSCAS Google Scholar
Sha, W. C. et al. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature336, 73–76 (1988) ArticleADSCAS Google Scholar
Jameson, S. C., Hogquist, K. A. & Bevan, M. J. Positive selection of thymocytes. Annu. Rev. Immunol.13, 93–126 (1995) ArticleCAS Google Scholar
Jerne, N. K. The somatic generation of immune recognition. Eur. J. Immunol.1, 1–9 (1971) ArticleCAS Google Scholar
Zerrahn, J., Held, W. & Raulet, D. H. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell88, 627–636 (1997) ArticleCAS Google Scholar
Merkenschlager, M. et al. How many thymocytes audition for selection? J. Exp. Med.186, 1149–1158 (1997) ArticleCAS Google Scholar
Blackman, M. et al. The T cell repertoire may be biased in favor of MHC recognition. Cell47, 349–357 (1986) ArticleCAS Google Scholar
Marrack, P., Scott-Browne, J. P., Dai, S., Gapin, L. & Kappler, J. W. Evolutionarily conserved amino acids that control TCR–MHC interaction. Annu. Rev. Immunol.26, 171–203 (2008) ArticleCAS Google Scholar
Rudolph, M. G., Stanfield, R. L. & Wilson, I. A. How TCRs bind MHCs, peptides, and coreceptors. Annu. Rev. Immunol.24, 419–466 (2006) ArticleCAS Google Scholar
Dai, S. et al. Crossreactive T cells spotlight the germline rules for αβ T cell-receptor interactions with MHC molecules. Immunity28, 324–334 (2008) ArticleCAS Google Scholar
Feng, D., Bond, C. J., Ely, L. K., Maynard, J. & Garcia, K. C. Structural evidence for a germline-encoded T cell receptor–major histocompatibility complex interaction ‘codon’. Nature Immunol.8, 975–983 (2007) ArticleCAS Google Scholar
Maynard, J. et al. Structure of an autoimmune T cell receptor complexed with class II peptide–MHC: insights into MHC bias and antigen specificity. Immunity22, 81–92 (2005) CASPubMed Google Scholar
Lee, P. U., Churchill, H. R., Daniels, M., Jameson, S. C. & Kranz, D. M. Role of 2CT cell receptor residues in the binding of self- and allo-major histocompatibility complexes. J. Exp. Med.191, 1355–1364 (2000) ArticleCAS Google Scholar
Manning, T. C. et al. Alanine scanning mutagenesis of an αβ T cell receptor: mapping the energy of antigen recognition. Immunity8, 413–425 (1998) ArticleCAS Google Scholar
Jameson, S. C. Maintaining the norm: T-cell homeostasis. Nature Rev. Immunol.2, 547–556 (2002) ArticleCAS Google Scholar
Arden, B., Clark, S. P., Kabelitz, D. & Mak, T. W. Mouse T-cell receptor variable gene segment families. Immunogenetics42, 501–530 (1995) CASPubMed Google Scholar
Grubin, C. E., Kovats, S., deRoos, P. & Rudensky, A. Y. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity7, 197–208 (1997) ArticleCAS Google Scholar
Wong, P., Goldrath, A. W. & Rudensky, A. Y. Competition for specific intrathymic ligands limits positive selection in a TCR transgenic model of CD4+ T cell development. J. Immunol.164, 6252–6259 (2000) ArticleCAS Google Scholar
Scott-Browne, J. P. et al. Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nature Immunol.8, 1105–1113 (2007) ArticleCAS Google Scholar
White, J., Pullen, A., Choi, K., Marrack, P. & Kappler, J. W. Antigen recognition properties of mutant V β 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor. J. Exp. Med.177, 119–125 (1993) ArticleCAS Google Scholar
Arden, B., Clark, S. P., Kabelitz, D. & Mak, T. W. Mouse T-cell receptor variable gene segment families. Immunogenetics42, 501–530 (1995) CASPubMed Google Scholar
Yague, J. et al. The T cell receptor: the α and β chains define idiotype, and antigen and MHC specificity. Cell42, 81–87 (1985) ArticleCAS Google Scholar
White, J. et al. Two better cell lines for making hybridomas expressing specific T cell receptors. J. Immunol.143, 1822–1824 (1989) CASPubMed Google Scholar
Kappler, J. W., Skidmore, B., White, J. & Marrack, P. Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition. J. Exp. Med.153, 1198–1214 (1981) ArticleCAS Google Scholar
Huseby, E. S. et al. How the T cell repertoire becomes peptide and MHC specific. Cell122, 247–260 (2005) ArticleCAS Google Scholar
Marcin, P. et al. JColorGrid: software for the visualization of biological measurements. BMC Bioinformatics7, 225 (2006) Article Google Scholar