Germline-encoded amino acids in the αβ T-cell receptor control thymic selection (original) (raw)

References

  1. Zinkernagel, R. M. & Doherty, P. C. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248, 701–702 (1974)
    Article ADS CAS Google Scholar
  2. Bevan, M. J. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 269, 417–418 (1977)
    Article ADS CAS Google Scholar
  3. Fink, P. J. & Bevan, M. J. H-2 antigens of the thymus determine lymphocyte specificity. J. Exp. Med. 148, 766–775 (1978)
    Article CAS Google Scholar
  4. Zinkernagel, R. M. et al. On the thymus in the differentiation of “H-2 self-recognition” by T cells: evidence for dual recognition? J. Exp. Med. 147, 882–896 (1978)
    Article CAS Google Scholar
  5. Kisielow, P., Teh, H. S., Bluthmann, H. & von Boehmer, H. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335, 730–733 (1988)
    Article ADS CAS Google Scholar
  6. Sha, W. C. et al. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336, 73–76 (1988)
    Article ADS CAS Google Scholar
  7. Jameson, S. C., Hogquist, K. A. & Bevan, M. J. Positive selection of thymocytes. Annu. Rev. Immunol. 13, 93–126 (1995)
    Article CAS Google Scholar
  8. Jerne, N. K. The somatic generation of immune recognition. Eur. J. Immunol. 1, 1–9 (1971)
    Article CAS Google Scholar
  9. Zerrahn, J., Held, W. & Raulet, D. H. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88, 627–636 (1997)
    Article CAS Google Scholar
  10. Merkenschlager, M. et al. How many thymocytes audition for selection? J. Exp. Med. 186, 1149–1158 (1997)
    Article CAS Google Scholar
  11. Blackman, M. et al. The T cell repertoire may be biased in favor of MHC recognition. Cell 47, 349–357 (1986)
    Article CAS Google Scholar
  12. Marrack, P., Scott-Browne, J. P., Dai, S., Gapin, L. & Kappler, J. W. Evolutionarily conserved amino acids that control TCR–MHC interaction. Annu. Rev. Immunol. 26, 171–203 (2008)
    Article CAS Google Scholar
  13. Rudolph, M. G., Stanfield, R. L. & Wilson, I. A. How TCRs bind MHCs, peptides, and coreceptors. Annu. Rev. Immunol. 24, 419–466 (2006)
    Article CAS Google Scholar
  14. Dai, S. et al. Crossreactive T cells spotlight the germline rules for αβ T cell-receptor interactions with MHC molecules. Immunity 28, 324–334 (2008)
    Article CAS Google Scholar
  15. Feng, D., Bond, C. J., Ely, L. K., Maynard, J. & Garcia, K. C. Structural evidence for a germline-encoded T cell receptor–major histocompatibility complex interaction ‘codon’. Nature Immunol. 8, 975–983 (2007)
    Article CAS Google Scholar
  16. Maynard, J. et al. Structure of an autoimmune T cell receptor complexed with class II peptide–MHC: insights into MHC bias and antigen specificity. Immunity 22, 81–92 (2005)
    CAS PubMed Google Scholar
  17. Lee, P. U., Churchill, H. R., Daniels, M., Jameson, S. C. & Kranz, D. M. Role of 2CT cell receptor residues in the binding of self- and allo-major histocompatibility complexes. J. Exp. Med. 191, 1355–1364 (2000)
    Article CAS Google Scholar
  18. Manning, T. C. et al. Alanine scanning mutagenesis of an αβ T cell receptor: mapping the energy of antigen recognition. Immunity 8, 413–425 (1998)
    Article CAS Google Scholar
  19. Jameson, S. C. Maintaining the norm: T-cell homeostasis. Nature Rev. Immunol. 2, 547–556 (2002)
    Article CAS Google Scholar
  20. Arden, B., Clark, S. P., Kabelitz, D. & Mak, T. W. Mouse T-cell receptor variable gene segment families. Immunogenetics 42, 501–530 (1995)
    CAS PubMed Google Scholar
  21. Grubin, C. E., Kovats, S., deRoos, P. & Rudensky, A. Y. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7, 197–208 (1997)
    Article CAS Google Scholar
  22. Wong, P., Goldrath, A. W. & Rudensky, A. Y. Competition for specific intrathymic ligands limits positive selection in a TCR transgenic model of CD4+ T cell development. J. Immunol. 164, 6252–6259 (2000)
    Article CAS Google Scholar
  23. Scott-Browne, J. P. et al. Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nature Immunol. 8, 1105–1113 (2007)
    Article CAS Google Scholar
  24. White, J., Pullen, A., Choi, K., Marrack, P. & Kappler, J. W. Antigen recognition properties of mutant V β 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor. J. Exp. Med. 177, 119–125 (1993)
    Article CAS Google Scholar
  25. Arden, B., Clark, S. P., Kabelitz, D. & Mak, T. W. Mouse T-cell receptor variable gene segment families. Immunogenetics 42, 501–530 (1995)
    CAS PubMed Google Scholar
  26. Yague, J. et al. The T cell receptor: the α and β chains define idiotype, and antigen and MHC specificity. Cell 42, 81–87 (1985)
    Article CAS Google Scholar
  27. White, J. et al. Two better cell lines for making hybridomas expressing specific T cell receptors. J. Immunol. 143, 1822–1824 (1989)
    CAS PubMed Google Scholar
  28. Kappler, J. W., Skidmore, B., White, J. & Marrack, P. Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition. J. Exp. Med. 153, 1198–1214 (1981)
    Article CAS Google Scholar
  29. Huseby, E. S. et al. How the T cell repertoire becomes peptide and MHC specific. Cell 122, 247–260 (2005)
    Article CAS Google Scholar
  30. Marcin, P. et al. JColorGrid: software for the visualization of biological measurements. BMC Bioinformatics 7, 225 (2006)
    Article Google Scholar

Download references