Common variants conferring risk of schizophrenia (original) (raw)
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Acknowledgements
We thank the subjects and their relatives and staff at the recruitment centres. This work was sponsored by EU grants LSHM-CT-2006-037761 (Project SGENE), PIAP-GA-2008-218251 (Project PsychGene) and HEALTH-F2-2009-223423 (Project PsychCNVs). Genotyping of the Dutch samples was sponsored by NIMH funding, R01 MH078075. This work was also supported by the National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF) and Marie Curie grant PIAP-GA-2008-218251 (PsychGene). M.M.N. received support from the Alfried Krupp von Bohlen und Halbach-Stiftung. We are grateful to S. Schreiber and M. Krawczak for providing genotype data for PopGen controls, and to K.-H. Jöckel and R. Erbel for providing control individuals from the Heinz Nixdorf Recall Study. Recruitment of the patients from Munich was partially supported by GlaxoSmithKline. We are grateful to the Genetics Research Centre GmbH, an initiative by GlaxoSmithKline and LMU. The Northern Finland Birth Cohort 1966 (NFBC66) is thanked for providing population controls for the study. The genotyping of NFBC66 was financially supported by National Institutes of Health grant 1R01HL087679-01, STAMPEED.
Author Contributions H.S., S.S., D.A.C., D.S.C., D.R., E. Sigurdsson and K.S. wrote the first draft of the paper. M.H., B.B.M., P.M., I.G., H.-J.M., A.H., A.C.N., G.F., N.W., J.L., J. Suvisaari, A.T.-H., T.T., E.B., R.M., M.R., S. Tosato, S.D., I.M., J.O., O.A.A., M.R., R.A.O., L.A.K., O.G., A.D.B., M. Nyegaard, A.F.-J., M. Nordentoft, D.H., B.N.-P., Y.B., R.B., H.B.R., S. Timm, M.M., I.B., J.M.R., L.A., V.K., J. Sanjuan, R.F., E.V., U.E., M.P., J.L.Y., N.B.F., R.M.C., V.G., A.C., C.A., J.C., E.G.J., L.T., I.A., O.M., P.B.M., B.F., T.P. and GROUP recruited, diagnosed and gathered phenotypes. H.S., D.R., R.d.F., E. Strengman, T.S., P.M.M., T.T., J.R.G., U.T., H.P., D.B.G., T.W., D.A.C., L.P., A.K., D.S.C. and K.S. planned, supervised and coordinated the work. S.S., H.S., S.C., P.O., G.M., A.I., T.E.T., O.P.H.P., D.G., K.V.S., M.M.N., T.H. and A.K. analysed the data. All authors contributed to the current version of the paper.
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Author notes
- These authors contributed equally to this work.
Authors and Affiliations
- deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.,
Hreinn Stefansson, Stacy Steinberg, Omar Gustafsson, Andres Ingason, Yvonne Böttcher, Pall Olason, Gisli Masson, Jeffrey R. Gulcher, Ragnheidur Fossdal, Thorgeir E. Thorgeirsson, Unnur Thorsteinsdottir, Augustine Kong & Kari Stefansson - Department of Medical Genetics and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.,
Roel A. Ophoff & Eric Strengman - UCLA Center for Neurobehavioral Genetics, Charles E. Young Drive South, Los Angeles, California 90024, USA.,
Roel A. Ophoff, Nelson B. Freimer & Rita M. Cantor - Department of Psychiatry, Ullevål University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166, N-0407 Oslo, Norway.,
Ole A. Andreassen & Ingrid Melle - Department of Genomics, Life and Brain Center, University of Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany.,
Sven Cichon & Manuel Mattheisen - Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians-University, Nußbaumstrasse 7, 80336 Munich, Germany.,
Dan Rujescu, Annette Hartmann & Ina Giegling - Research Institute of Biological Psychiatry, Mental Health Centre Sct. Hans Copenhagen University Hospital, DK-4000 Roskilde, Denmark.,
Thomas Werge, Thomas Hansen & Henrik B. Rasmussen - Institute of Molecular Medicine, Biomedicum Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland.,
Olli P. H. Pietiläinen & Leena Peltonen - Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.,
Olli P. H. Pietiläinen & Leena Peltonen - Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240 Risskov, Denmark.,
Ole Mors & Anders D. Børglum - National Centre for Register-based Research, Aarhus University, Taasingegade 1, DK-8000 Aarhus, Denmark.,
Preben B. Mortensen - Department of Psychiatry, National University Hospital, Hringbraut, 101 Reykjavik, Iceland.,
Engilbert Sigurdsson, Brynja B. Magnusdottir, Thordur Sigmundsson, Magnus Haraldsson & Hannes Petursson - University of Iceland, School of Medicine, Laeknagardi, 101 Reykjavik, Iceland.,
Engilbert Sigurdsson, Brynja B. Magnusdottir, Thordur Sigmundsson, Magnus Haraldsson, Unnur Thorsteinsdottir, Hannes Petursson & Kari Stefansson - Department of Human Genetics, The Bartholin Building, Aarhus University, DK-8000 Arhus C, Denmark.,
Mette Nyegaard & Anders D. Børglum - Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland.,
Annamari Tuulio-Henriksson, Jaana Suvisaari & Jouko Lonnqvist - Department for Molecular Medicine, National Public Health Institute, Biomedicum, Haartmaninkatu 8, 00290 Helsinki, Finland.,
Tiina Paunio - Mental Health Centre Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen Ø, Denmark.,
Anders Fink-Jensen - Psychiatric Centre Bisbebjerg, Building 13A, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark.,
Merete Nordentoft - Department Clinical Chemistry and Immunology, Section of Neonatal Screening and Hormones, The State Serum Institute, Artillerivej 5, 2300 Copenhagen S, Denmark.,
David Hougaard & Bent Norgaard-Pedersen - Department of Neurology, 57 Nordre Ringvej, Glostrup Hospital, Glostrup, DK-2600 Copenhagen, Denmark.,
Jes Olesen - Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, J5, D-68159 Mannheim, Germany.,
René Breuer & Marcella Rietschel - Department of Psychiatry, Ludwig-Maximilians-University, Nußbaumstrasse 7, 80336 Munich, Germany.,
Hans-Jürgen Möller - Mental Health Centre Frederiksberg, Copenhagen University Hospital, DK-2000 Frederiksberg, Denmark.,
Sally Timm - Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest 1083, Hungary.,
István Bitter & János M. Réthelyi - Section of Psychiatry and Clinical Psychology, University of Verona, Verona, 37134 Verona, Italy.,
Mirella Ruggeri & Sarah Tosato - Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.,
Barbara Franke - Department of Epidemiology and Biostatistics and Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.,
Lambertus A. Kiemeney - Department of Medical Genetics, Ulleval University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166, N-0407 Oslo, Norway.,
Srdjan Djurovic - Mental Health Research Center, Russian Academy of Medical Sciences, Zagorodnoe sh. 2/2, 117152 Moscow, Russia.,
Lilia Abramova, Vasily Kaleda & Vera Golimbet - Unidad de Psiquiatría, Facultad de Medicina, Universidad de Valencia, CIBERSAM, 46010 Valencia, Spain.,
Julio Sanjuan - Departamento de Genética. Facultad de Biología, Universidad de Valencia, CIBERSAM, Spain.,
Rosa de Frutos - Division of Psychological Medicine, Institute of Psychiatry, King’s College, London SE5 8AF, UK.,
Elvira Bramon, Evangelos Vassos, Ulrich Ettinger, Marco Picchioni, Robin Murray & David A. Collier - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College, London SE5 8AF, UK.,
Evangelos Vassos, Ulrich Ettinger, Timi Toulopoulou & Robin Murray - Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen AB25 2ZD, UK.,
Gillian Fraser & David St Clair - Ravenscraig hospital, Inverkip Road, Greenock PA16 9HA, UK.,
Nicholas Walker - Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, 4011 GSRB II 103 Research Drive, Duke University, DUMC Box 3471, Durham, North Carolina 27708, USA.,
Anna C. Need, Dongliang Ge, Kevin V. Shianna & David B. Goldstein - Department of Human Genetics, UCLA, 695 Charles Young Drive South, Los Angeles, California 90095, USA.,
Joeng Lim Yoon & Rita M. Cantor - Fundación Pública Galega de Medicina Xenómica-Complexo Universitario Hospitalario de Santiago, and CIBER de Enfermedades Raras (CIBERER), IML- Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.,
Angel Carracedo - Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain.,
Celso Arango - Fundación Pública Galega de Medicina Xenómica, and CIBER de Enfermedades Raras (CIBERER), 46010 Valencia, Spain.,
Javier Costas - Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, R5:00, SE-171 76 Stockholm, Sweden.,
Erik G. Jönsson, Lars Terenius & Ingrid Agartz - Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D-53111 Bonn, Germany.,
Markus M. Nöthen - Clinical Imaging Centre, Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Hammersmith Hospital, London W12 ONN, UK.,
Paul M. Matthews - Medical Genetics, GlaxoSmithKline R&D, Via A. Fleming 4, 37135 Verona, Italy.,
Pierandrea Muglia - Department of Psychiatry, Psychiatric Laboratory, West China Hospital, Sichuan University, 610065 Sichuan, China.,
David A. Collier - Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Postbus 85060, 3508 AB, Utrecht, The Netherlands.,
René S. Kahn & Wiepke Cahn - Department of Psychiatry, Academic Medical Centre University of Amsterdam, Amsterdam, NL326 Groot-Amsterdam, The Netherlands.,
Don H. Linszen & Lieuwe de Haan - Maastricht University Medical Centre, South Limburg Mental Health Research and Teaching Network, P. Debyelaan 25, 6229 HX Maastricht, Maastricht, The Netherlands.,
Hreinn Stefansson, Roel A. Ophoff, Stacy Steinberg, Jim van Os, Lydia Krabbendam & Inez Myin-Germeys - Department of Psychiatry, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.,
Durk Wiersma & Richard Bruggeman
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†Genetic Risk and Outcome in Psychosis (GROUP)
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- , Lieuwe de Haan
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- & Inez Myin-Germeys
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Correspondence toKari Stefansson.
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Competing interests
Some of the authors including Kari Stefansson (CEO of deCODE genetics), Jeffrey R. Gulcher (CSO of deCODE genetics) and Augustine Kong (VP Statistics at deCODE genetics) are shareholders in deCODE genetics.
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This file contains Supplementary Methods, Supplementary Tables 1-6, Supplementary Figure 1 with Legend and Supplementary References. (PDF 205 kb)
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Stefansson, H., Ophoff, R., Steinberg, S. et al. Common variants conferring risk of schizophrenia.Nature 460, 744–747 (2009). https://doi.org/10.1038/nature08186
- Received: 16 March 2009
- Accepted: 05 June 2009
- Published: 01 July 2009
- Issue Date: 06 August 2009
- DOI: https://doi.org/10.1038/nature08186