Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma (original) (raw)

• Hayden, M. S. & Ghosh, S. Signaling to NF-κB. Genes Dev. 18, 2195–2224 (2004)
  Article CAS Google Scholar
• Greten, F. R. et al. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118, 285–296 (2004)
  Article CAS Google Scholar
• Hanson, J. L., Hawke, N. A., Kashatus, D. & Baldwin, A. S. The nuclear factor κB subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation. Cancer Res. 64, 7248–7255 (2004)
  Article CAS Google Scholar
• Luedde, T. et al. Deletion of NEMO/IKKγ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 11, 119–132 (2007)
  Article CAS Google Scholar
• Maeda, S., Kamata, H., Luo, J. L., Leffert, H. & Karin, M. IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121, 977–990 (2005)
  Article CAS Google Scholar
• Pikarsky, E. et al. NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature 431, 461–466 (2004)
  Article ADS CAS Google Scholar
• Herbst, R. S., Heymach, J. V. & Lippman, S. M. Lung cancer. N. Engl. J. Med. 359, 1367–1380 (2008)
  Article CAS Google Scholar
• Finco, T. S. et al. Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation. J. Biol. Chem. 272, 24113–24116 (1997)
  Article CAS Google Scholar
• Huang, W. C., Ju, T. K., Hung, M. C. & Chen, C. C. Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB. Mol. Cell 26, 75–87 (2007)
  Article Google Scholar
• Kawauchi, K., Araki, K., Tobiume, K. & Tanaka, N. p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation. Nature Cell Biol. 10, 611–618 (2008)
  Article CAS Google Scholar
• Kawauchi, K., Araki, K., Tobiume, K. & Tanaka, N. Loss of p53 enhances catalytic activity of IKKβ through O-linked β-_N_-acetyl glucosamine modification. Proc. Natl Acad. Sci. USA 106, 3431–3436 (2009)
  Article ADS CAS Google Scholar
• Ravi, R. et al. p53-mediated repression of nuclear factor-κB RelA via the transcriptional integrator p300. Cancer Res. 58, 4531–4536 (1998)
  CAS PubMed Google Scholar
• Wadgaonkar, R. et al. CREB-binding protein is a nuclear integrator of nuclear factor-κB and p53 signaling. J. Biol. Chem. 274, 1879–1882 (1999)
  Article CAS Google Scholar
• Webster, G. A. & Perkins, N. D. Transcriptional cross talk between NF-κB and p53. Mol. Cell. Biol. 19, 3485–3495 (1999)
  Article CAS Google Scholar
• Jackson, E. L. et al. The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res. 65, 10280–10288 (2005)
  Article CAS Google Scholar
• Jackson, E. L. et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15, 3243–3248 (2001)
  Article CAS Google Scholar
• Jonkers, J. et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nature Genet. 29, 418–425 (2001)
  Article CAS Google Scholar
• Johnson, L. et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410, 1111–1116 (2001)
  Article ADS CAS Google Scholar
• Ventura, A. et al. Restoration of p53 function leads to tumour regression in vivo . Nature 445, 661–665 (2007)
  Article CAS Google Scholar
• Rothwarf, D. M., Zandi, E., Natoli, G. & Karin, M. IKK-γ is an essential regulatory subunit of the IκB kinase complex. Nature 395, 297–300 (1998)
  Article ADS CAS Google Scholar
• Yamaoka, S. et al. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 93, 1231–1240 (1998)
  Article CAS Google Scholar
• Ventura, A. et al. Cre-lox-regulated conditional RNA interference from transgenes. Proc. Natl Acad. Sci. USA 101, 10380–10385 (2004)
  Article ADS CAS Google Scholar
• Perl, A.-K. T., Tichelaar, J. W. & Whitsett, J. A. Conditional gene expression in the respiratory epithelium of the mouse. Transgenic Res. 11, 21–29 (2002)
  Article CAS Google Scholar
• Nenci, A. et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446, 557–561 (2007)
  Article ADS CAS Google Scholar
• Stathopoulos, G. T. et al. Epithelial NF-κB activation promotes urethane-induced lung carcinogenesis. Proc. Natl Acad. Sci. USA 104, 18514–18519 (2007)
  Article ADS CAS Google Scholar
• Fong, C. H. et al. An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation. J. Exp. Med. 205, 1269–1276 (2008)
  Article CAS Google Scholar
• Hagemann, T. et al. “Re-educating” tumor-associated macrophages by targeting NF-κB. J. Exp. Med. 205, 1261–1268 (2008)
  Article CAS Google Scholar
• Pikarsky, E. & Ben-Neriah, Y. NF-κB inhibition: a double-edged sword in cancer? Eur. J. Cancer 42, 779–784 (2006)
  Article CAS Google Scholar
• DuPage, M., Dooley, A. L. & Jacks, T. Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nature Protocols 4, 1064–1072 (2009)
  Article CAS Google Scholar
• Schmittgen, T. D. & Livak, K. J. Analyzing real-time PCR data by the comparative C T method. Nature Protocols 3, 1101–1108 (2008)
  Article CAS Google Scholar