Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma (original) (raw)

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Gene expression profiling data have been deposited in the Gene Expression Omnibus (GEO) under accession number GSE18817.

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Acknowledgements

We thank L. Honigberg for PCI-32765, L. Dang for IKK-β inhibitors, S. Ansher for dasatinib, and S. Tohda for the TMD8 cell line. This research was supported by the Intramural Research Program of the National Institutes of Health, the National Cancer Institute, the Center for Cancer Research, the National Institute of Allergy and Infectious Disease, and the National Human Genome Research Institute. P.B.R. was a Howard Hughes Medical Institute-National Institutes of Health Research Scholar.

Author Contributions R.E.D., V.N.N., G.L., P.T., R.M.Y., P.B.R., H.K., L.L. and A.L.S. designed and performed experiments. H.Z., Y.Y. and W.X. performed experiments. G.W., W.X. and J.P. analysed data. J.J. and C.J.T. synthesized reagents. A.R., G.O., H.K.M.-H., R.D.G., J.M.C., N.A.J., L.M.R., E.C., E.S.J., W.H.W., J.D., E.B.S., R.I.F., R.M.B., R.R.T., J.R.C., D.D.W. and W.C.C. supplied samples from patients and reviewed pathological and clinical data. S.K.P. supervised research. L.M.S. designed and supervised research and wrote the manuscript.

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Author notes

1. R. Eric Davis, Vu N. Ngo and Georg Lenz: These authors contributed equally to this work.

Authors and Affiliations

1. Metabolism Branch,,
   R. Eric Davis, Vu N. Ngo, Georg Lenz, Ryan M. Young, Paul B. Romesser, Holger Kohlhammer, Laurence Lamy, Hong Zhao, Yandan Yang, Weihong Xu, Arthur L. Shaffer, Wyndham H. Wilson & Louis M. Staudt
2. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA ,
   Elaine S. Jaffe
3. Laboratory of Immunogenetics, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA ,
   Pavel Tolar & Susan K. Pierce
4. Howard Hughes Medical Institute – National Institutes of Health Research Scholars Program, Bethesda, Maryland 20892, USA ,
   Paul B. Romesser
5. Division of Cancer Treatment and Diagnosis, Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA,
   George Wright
6. Division of Computational Bioscience, Bioinformatics and Molecular Analysis Section, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA,
   Wenming Xiao & John Powell
7. NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA ,
   Jian-kang Jiang & Craig J. Thomas
8. Department of Pathology, University of Würzburg, 97080 Würzburg, Germany
   Andreas Rosenwald & Hans Konrad Muller-Hermelink
9. Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, 70376 Stuttgart, Germany
   German Ott
10. British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4E6 ,
    Randy D. Gascoyne, Joseph M. Connors & Nathalie A. Johnson
11. Department of Pathology, University of Arizona, Tucson, Arizona 85724, USA,
    Lisa M. Rimsza
12. Southwest Oncology Group, 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan 48106, USA ,
    Lisa M. Rimsza, Richard I. Fisher, Rita M. Braziel, Raymond R. Tubbs & J. R. Cook
13. Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
    Elias Campo
14. Pathology Clinic, Rikshospitalet University Hospital, N-0310 Oslo, Norway
    Jan Delabie
15. Faculty Division of the Norwegian Radium Hospital, Institute for Cancer Research, Rikshospitalet University Hospital and Center for Cancer Biomedicine, University of Oslo, N-0310 Oslo, Norway
    Erlend B. Smeland
16. James P. Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, New York 14642, USA ,
    Richard I. Fisher
17. Oregon Health and Science University, Portland, Oregon 97239, USA ,
    Rita M. Braziel
18. Cleveland Clinic Pathology and Laboratory Medicine Institute, Cleveland, Ohio 44195, USA ,
    Raymond R. Tubbs & J. R. Cook
19. Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA,
    Dennis D. Weisenburger & Wing C. Chan

Authors

1. R. Eric Davis
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2. Vu N. Ngo
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3. Georg Lenz
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4. Pavel Tolar
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5. Ryan M. Young
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6. Paul B. Romesser
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7. Holger Kohlhammer
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8. Laurence Lamy
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9. Hong Zhao
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10. Yandan Yang
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11. Weihong Xu
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12. Arthur L. Shaffer
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13. George Wright
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14. Wenming Xiao
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15. John Powell
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16. Jian-kang Jiang
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17. Craig J. Thomas
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18. Andreas Rosenwald
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19. German Ott
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20. Hans Konrad Muller-Hermelink
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21. Randy D. Gascoyne
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22. Joseph M. Connors
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23. Nathalie A. Johnson
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24. Lisa M. Rimsza
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25. Elias Campo
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26. Elaine S. Jaffe
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27. Wyndham H. Wilson
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28. Jan Delabie
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29. Erlend B. Smeland
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30. Richard I. Fisher
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31. Rita M. Braziel
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32. Raymond R. Tubbs
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33. J. R. Cook
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34. Dennis D. Weisenburger
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35. Wing C. Chan
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36. Susan K. Pierce
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37. Louis M. Staudt
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Corresponding author

Correspondence toLouis M. Staudt.

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The authors declare no competing financial interests.

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Davis, R., Ngo, V., Lenz, G. et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.Nature 463, 88–92 (2010). https://doi.org/10.1038/nature08638

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• Received: 18 April 2009
• Accepted: 04 November 2009
• Issue Date: 07 January 2010
• DOI: https://doi.org/10.1038/nature08638