Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss (original) (raw)

• Zhou, Q. & Melton, D. A. Extreme makeover: converting one cell into another. Cell Stem Cell 3, 382–388 (2008)
  Article CAS PubMed Google Scholar
• Uhlenhaut, N. H. et al. Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell 139, 1130–1142 (2009)
  Article CAS PubMed Google Scholar
• Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D. A. In vivo reprogramming of adult pancreatic exocrine cells to β-cells. Nature 455, 627–632 (2008)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Bonal, C. et al. Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice. Gastroenterology 136, 309–319 (2009)
  Article CAS PubMed Google Scholar
• Teta, M., Long, S. Y., Wartschow, L. M., Rankin, M. M. & Kushner, J. A. Very slow turnover of β-cells in aged adult mice. Diabetes 54, 2557–2567 (2005)
  Article CAS PubMed Google Scholar
• Desgraz, R. & Herrera, P. L. Pancreatic neurogenin 3-expressing cells are unipotent islet precursors. Development 136, 3567–3574 (2009)
  Article CAS PubMed PubMed Central Google Scholar
• Dor, Y., Brown, J., Martinez, O. I. & Melton, D. A. Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429, 41–46 (2004)
  Article ADS CAS PubMed Google Scholar
• Rankin, M. M. & Kushner, J. A. Adaptive β-cell proliferation is severely restricted with advanced age. Diabetes 58, 1365–1372 (2009)
  Article CAS PubMed PubMed Central Google Scholar
• Matveyenko, A. V. & Butler, P. C. Relationship between β-cell mass and diabetes onset. Diabetes Obes. Metab. 10 (suppl. 4). 23–31 (2008)
  Article CAS PubMed PubMed Central Google Scholar
• Wang, R. N., Bouwens, L. & Kloppel, G. β-cell growth in adolescent and adult rats treated with streptozotocin during the neonatal period. Diabetologia 39, 548–557 (1996)
  Article CAS PubMed Google Scholar
• Herold, K. C. et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med. 346, 1692–1698 (2002)
  Article CAS PubMed Google Scholar
• Thyssen, S., Arany, E. & Hill, D. J. Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin. Endocrinology 147, 2346–2356 (2006)
  Article CAS PubMed Google Scholar
• Bonner-Weir, S., Baxter, L. A., Schuppin, G. T. & Smith, F. E. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42, 1715–1720 (1993)
  Article CAS PubMed Google Scholar
• Wang, R. N., Kloppel, G. & Bouwens, L. Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia 38, 1405–1411 (1995)
  Article CAS PubMed Google Scholar
• Xu, G., Stoffers, D. A., Habener, J. F. & Bonner-Weir, S. Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48, 2270–2276 (1999)
  Article CAS PubMed Google Scholar
• Nir, T., Melton, D. A. & Dor, Y. Recovery from diabetes in mice by beta cell regeneration. J. Clin. Invest. 117, 2553–2561 (2007)
  Article CAS PubMed PubMed Central Google Scholar
• Baeyens, L. et al. In vitro generation of insulin-producing β cells from adult exocrine pancreatic cells. Diabetologia 48, 49–57 (2005)
  Article CAS PubMed Google Scholar
• Bonner-Weir, S. & Weir, G. C. New sources of pancreatic β-cells. Nature Biotechnol. 23, 857–861 (2005)
  Article CAS Google Scholar
• Trucco, M. Regeneration of the pancreatic β cell. J. Clin. Invest. 115, 5–12 (2005)
  Article CAS PubMed PubMed Central Google Scholar
• Xu, X. et al. β cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132, 197–207 (2008)
  Article CAS PubMed Google Scholar
• Herrera, P. L. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127, 2317–2322 (2000)
  Article CAS PubMed Google Scholar
• Herrera, P. L., Nepote, V. & Delacour, A. Pancreatic cell lineage analyses in mice. Endocrine 19, 267–278 (2002)
  Article CAS PubMed Google Scholar
• Herrera, P. L. et al. Ablation of islet endocrine cells by targeted expression of hormone- promoter-driven toxigenes. Proc. Natl Acad. Sci. USA 91, 12999–13003 (1994)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Naglich, J. G., Metherall, J. E., Russell, D. W. & Eidels, L. Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell 69, 1051–1061 (1992)
  Article CAS PubMed Google Scholar
• Saito, M. et al. Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nature Biotechnol. 19, 746–750 (2001)
  Article CAS Google Scholar
• Srinivas, S. et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4 (2001)
  Article CAS PubMed PubMed Central Google Scholar
• Cano, D. A. et al. Regulated β-cell regeneration in the adult mouse pancreas. Diabetes 57, 958–966 (2008)
  Article CAS PubMed Google Scholar
• Wang, Z. V. et al. PANIC-ATTAC: a mouse model for inducible and reversible β-cell ablation. Diabetes 57, 2137–2148 (2008)
  Article CAS PubMed PubMed Central Google Scholar
• Gerich, J. E., Lorenzi, M., Karam, J. H., Schneider, V. & Forsham, P. H. Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus. J. Am. Med. Assoc. 234, 159–165 (1975)
  Article CAS Google Scholar
• Perl, A. K., Wert, S. E., Nagy, A., Lobe, C. G. & Whitsett, J. A. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc. Natl Acad. Sci. USA 99, 10482–10487 (2002)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Quoix, N. et al. The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic α-cells. FEBS Lett. 581, 4235–4240 (2007)
  Article CAS PubMed Google Scholar
• Li, W. C., Horb, M. E., Tosh, D. & Slack, J. M. In vitro transdifferentiation of hepatoma cells into functional pancreatic cells. Mech. Dev. 122, 835–847 (2005)
  Article CAS PubMed Google Scholar
• Fodor, A. et al. Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach. Diabetologia 50, 121–130 (2007)
  Article CAS PubMed Google Scholar
• Chakrabarti, S. K., James, J. C. & Mirmira, R. G. Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. J. Biol. Chem. 277, 13286–13293 (2002)
  Article CAS PubMed Google Scholar
• Ritz-Laser, B. et al. Ectopic expression of the β-cell specific transcription factor Pdx1 inhibits glucagon gene transcription. Diabetologia 46, 810–821 (2003)
  Article CAS PubMed Google Scholar
• Schisler, J. C. et al. The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet β cells. Proc. Natl Acad. Sci. USA 102, 7297–7302 (2005)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Collombat, P. et al. Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev. 17, 2591–2603 (2003)
  Article CAS PubMed PubMed Central Google Scholar
• Collombat, P. et al. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into α and subsequently β cells. Cell 138, 449–462 (2009)
  Article CAS PubMed PubMed Central Google Scholar
• Bonal, C. & Herrera, P. L. Genes controlling pancreas ontogeny. Int. J. Dev. Biol. 52, 823–835 (2008)
  Article CAS PubMed Google Scholar
• Rorsman, P., Salehi, S. A., Abdulkader, F., Braun, M. & MacDonald, P. E. KATP-channels and glucose-regulated glucagon secretion. Trends Endocrinol. Metab. 19, 277–284 (2008)
  Article CAS PubMed Google Scholar
• Heimberg, H., De Vos, A., Pipeleers, D., Thorens, B. & Schuit, F. Differences in glucose transporter gene expression between rat pancreatic α- and β-cells are correlated to differences in glucose transport but not in glucose utilization. J. Biol. Chem. 270, 8971–8975 (1995)
  Article CAS PubMed Google Scholar
• Heimberg, H. et al. The glucose sensor protein glucokinase is expressed in glucagon-producing α-cells. Proc. Natl Acad. Sci. USA 93, 7036–7041 (1996)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Burgoyne, R. D. & Morgan, A. Secretory granule exocytosis. Physiol. Rev. 83, 581–632 (2003)
  Article CAS PubMed Google Scholar
• Fausto, N. Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 39, 1477–1487 (2004)
  Article PubMed Google Scholar
• Meier, J. J., Bhushan, A., Butler, A. E., Rizza, R. A. & Butler, P. C. Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48, 2221–2228 (2005)
  Article CAS PubMed Google Scholar
• Meier, J. J. et al. Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 49, 1838–1844 (2006)
  Article CAS PubMed Google Scholar
• Karges, B. et al. Complete long-term recovery of β-cell function in autoimmune type 1 diabetes after insulin treatment. Diabetes Care 27, 1207–1208 (2004)
  Article CAS PubMed Google Scholar
• Karges, B. et al. Immunological mechanisms associated with long-term remission of human type 1 diabetes. Diabetes Metab. Res. Rev. 22, 184–189 (2006)
  Article CAS PubMed Google Scholar
• Hogan, B., Beddington, R., Costantini, F. & Lacy, E. Manipulating the Mouse Embryo. A Laboratory Manual 2nd edn, Ch. 7 289–358 (Cold Spring Harbor Laboratory Press, 1994)
  Google Scholar
• Nguyen, V. X., Nix, D. E., Gillikin, S. & Schentag, J. J. Effect of oral antacid administration on the pharmacokinetics of intravenous doxycycline. Antimicrob. Agents Chemother. 33, 434–436 (1989)
  Article CAS PubMed PubMed Central Google Scholar