A novel pathway regulates memory and plasticity via SIRT1 and miR-134 (original) (raw)

References

  1. Finkel, T., Deng, C. X. & Mostoslavsky, R. Recent progress in the biology and physiology of sirtuins. Nature 460, 587–591 (2009)
    Article ADS CAS Google Scholar
  2. Kaeberlein, M., McVey, M. & Guarente, L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570–2580 (1999)
    Article CAS Google Scholar
  3. Nakahata, Y. et al. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134, 329–340 (2008)
    Article CAS Google Scholar
  4. Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M. & Sassone-Corsi, P. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science 324, 654–657 (2009)
    Article ADS CAS Google Scholar
  5. Kim, D. et al. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. EMBO J. 26, 3169–3179 (2007)
    Article CAS Google Scholar
  6. Renthal, W. et al. Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron 62, 335–348 (2009)
    Article CAS Google Scholar
  7. Cohen, D. E., Supinski, A. M., Bonkowski, M. S., Donmez, G. & Guarente, L. P. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev. 23, 2812–2817 (2009)
    Article CAS Google Scholar
  8. Cheng, H. L. et al. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl Acad. Sci. USA 100, 10794–10799 (2003)
    Article ADS CAS Google Scholar
  9. Broadbent, N. J., Squire, L. R. & Clark, R. E. Spatial memory, recognition memory, and the hippocampus. Proc. Natl Acad. Sci. USA 101, 14515–14520 (2004)
    Article ADS CAS Google Scholar
  10. Calhoun, M. E. et al. Comparative evaluation of synaptophysin-based methods for quantification of synapses. J. Neurocytol. 25, 821–828 (1996)
    Article CAS Google Scholar
  11. Kang, H. & Schuman, E. M. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267, 1658–1662 (1995)
    Article ADS CAS Google Scholar
  12. Frank, D. A. & Greenberg, M. E. CREB: a mediator of long-term memory from mollusks to mammals. Cell 79, 5–8 (1994)
    Article CAS Google Scholar
  13. Flavell, S. W. & Greenberg, M. E. Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. Annu. Rev. Neurosci. 31, 563–590 (2008)
    Article CAS Google Scholar
  14. Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J. & Greenberg, M. E. Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20, 709–726 (1998)
    Article CAS Google Scholar
  15. Hong, E. J., McCord, A. E. & Greenberg, M. E. A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron 60, 610–624 (2008)
    Article CAS Google Scholar
  16. Timmusk, T. et al. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10, 475–489 (1993)
    Article CAS Google Scholar
  17. Chiaruttini, C., Sonego, M., Baj, G., Simonato, M. & Tongiorgi, E. BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae. Mol. Cell. Neurosci. 37, 11–19 (2008)
    Article CAS Google Scholar
  18. Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215–233 (2009)
    Article CAS Google Scholar
  19. Fiore, R., Siegel, G. & Schratt, G. MicroRNA function in neuronal development, plasticity and disease. Biochim. Biophys. Acta 1779, 471–478 (2008)
    Article CAS Google Scholar
  20. Bushati, N. & Cohen, S. M. MicroRNAs in neurodegeneration. Curr. Opin. Neurobiol. 18, 292–296 (2008)
    Article CAS Google Scholar
  21. Schratt, G. M. et al. A brain-specific microRNA regulates dendritic spine development. Nature 439, 283–289 (2006)
    Article ADS CAS Google Scholar
  22. van der Veer, E. et al. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J. Biol. Chem. 282, 10841–10845 (2007)
    Article CAS Google Scholar
  23. Shi, Y., Lee, J. S. & Galvin, K. M. Everything you have ever wanted to know about Yin Yang 1. Biochim. Biophys. Acta 1332, F49–F66 (1997)
    CAS PubMed Google Scholar
  24. Fanselow, M. S. & Gale, G. D. The amygdala, fear, and memory. Ann. NY Acad. Sci. 985, 125–134 (2003)
    Article ADS Google Scholar
  25. Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M. & Tsai, L. H. Recovery of learning and memory is associated with chromatin remodelling. Nature 447, 178–182 (2007)
    Article ADS CAS Google Scholar
  26. Cohen, D. E., Supinski, A. M., Bonkowski, M. S., Donmez, G. & Guarente, L. P. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev. 23, 2812–2817 (2009)
    Article CAS Google Scholar
  27. Guan, J. S. et al. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459, 55–60 (2009)
    Article ADS CAS Google Scholar
  28. Fischer, A., Sananbenesi, F., Pang, P. T., Lu, B. & Tsai, L. H. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron 48, 825–838 (2005)
    Article CAS Google Scholar
  29. Doench, J. G. & Sharp, P. A. Specificity of microRNA target selection in translational repression. Genes Dev. 18, 504–511 (2004)
    Article CAS Google Scholar
  30. Morris, R. G., Garrud, P., Rawlins, J. N. & O'Keefe, J. Place navigation impaired in rats with hippocampal lesions. Nature 297, 681–683 (1982)
    Article ADS CAS Google Scholar
  31. Stefanko, D. P., Barrett, R. M., Ly, A. R., Reolon, G. K. & Wood, M. A. Modulation of long-term memory for object recognition via HDAC inhibition. Proc. Natl Acad. Sci. USA 106, 9447–9452 (2009)
    Article ADS CAS Google Scholar

Download references