Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia (original) (raw)

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Acknowledgements

This study was supported by a gift from Ted and Vada Stanley to the Cold Spring Harbor Laboratory, a gift to J.S. from the Beyster family foundation, NIH grants to J.S. (MH076431, HG04222), D.L.L. (MH071523), M.-C.K. (MH083989), P.A.I. (GM66232), F.M. (HL091061), D.K.W. (MH082945), M.K. (MH061399), L.E.D. (MH044245), grants to J.S., D.K.W., D.L.L. and M.-C.K from NARSAD, grants to A.C., M.G., D.M. from the Wellcome Trust (072894/Z/03/Z) and Science Foundation Ireland (08INIB1916), a career development award to D.K.W. by the Veterans Administration, and grants to D.L.L. from the Sidney R. Baer, Jr Foundation and Essel Foundation . We wish to thank the Genetic Association Information Network (GAIN), Molecular Genetics of Schizophrenia (MGS) and the Bipolar Genome Study (BiGS) for providing data for this study (investigators listed in the Supplementary Note). We wish to thank B. Trask, R. Malinow and J. Gleeson for discussions.

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Authors and Affiliations

  1. Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, 12824, New York, USA
    Vladimir Vacic, Shane McCarthy, Dheeraj Malhotra, Abhishek Bhandari & Jonathan Sebat
  2. Department of Computer Science, Columbia University, New York, 10027, New York, USA
    Vladimir Vacic
  3. Beyster Center for Genomics of Psychiatric Diseases, University of California, San Diego, La Jolla, 1020103, California, USA
    Dheeraj Malhotra, Hsun-Hua Chou, Abhishek Bhandari & Jonathan Sebat
  4. Department of Psychiatry, University of California, San Diego, La Jolla, 1020103, California, USA
    Dheeraj Malhotra, Hsun-Hua Chou, Abhishek Bhandari, Roser Corominas, Lilia M. Iakoucheva, David K. Welsh, John R. Kelsoe & Jonathan Sebat
  5. Department of Medicine, University of California, San Diego, La Jolla, 1020103, California, USA
    Fiona Murray, Marie Dell Aquila & Paul A. Insel
  6. Department of Pharmacology, University of California, San Diego, La Jolla, 1020103, California, USA
    Fiona Murray & Paul A. Insel
  7. Institute of Molecular Medicine and Department of Psychiatry, Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin 2, Ireland
    Aine Peoples, Derek W. Morris, Michael Gill & Aiden Corvin
  8. Seaver Autism Center, Mount Sinai School of Medicine, New York, 10029, New York, USA
    Vladimir Makarov & Seungtai Yoon
  9. Department of Psychiatry, Mount Sinai School of Medicine, New York, 10029, New York, USA
    Vladimir Makarov & Seungtai Yoon
  10. McLean Hospital, Belmont, 02478, Massachusetts, USA
    Olga Krastoshevsky, Verena Krause & Deborah L. Levy
  11. Faculty of Medicine, Universidad Andrés Bello, Santiago, Chile
    Verónica Larach-Walters
  12. Veterans Affairs San Diego Healthcare System, San Diego, 92161, California, USA
    David K. Welsh & John R. Kelsoe
  13. Center for Chronobiology, University of California, San Diego, La Jolla, 1020103, California, USA
    David K. Welsh
  14. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, 85004, Arizona, USA
    David Craig
  15. Institute for Genomic Medicine, University of California, San Diego, La Jolla, 1020103, California, USA
    John R. Kelsoe & Jonathan Sebat
  16. Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, 60637, Illinois, USA
    Elliot S. Gershon
  17. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, 77025, Texas, USA
    Suzanne M. Leal
  18. Division of Medical Genetics, University of California, San Diego, La Jolla, 1020103, California, USA
    Marie Dell Aquila
  19. Department of Psychiatry, University of Washington, Seattle, 98195, Washington, USA
    Jon McClellan
  20. Department of Genome Sciences, University of Washington, Seattle, 98195, Washington, USA
    Mary-Claire King
  21. Department of Medicine, University of Washington, Seattle, 98195, Washington, USA
    Mary-Claire King
  22. Department of Psychiatry, Columbia University, New York, 10027, New York, USA
    Maria Karayiorgou
  23. Department of Psychiatry, Boston VA Healthcare System and Harvard Medical School, Brockton, 02301, Massachusetts, USA
    Lynn E. DeLisi
  24. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, 1020103, California, USA
    Jonathan Sebat

Authors

  1. Vladimir Vacic
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  2. Shane McCarthy
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  3. Dheeraj Malhotra
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  4. Fiona Murray
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  5. Hsun-Hua Chou
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  6. Aine Peoples
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  7. Vladimir Makarov
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  8. Seungtai Yoon
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  9. Abhishek Bhandari
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  10. Roser Corominas
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  11. Lilia M. Iakoucheva
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  12. Olga Krastoshevsky
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  13. Verena Krause
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  14. Verónica Larach-Walters
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  15. David K. Welsh
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  16. David Craig
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  17. John R. Kelsoe
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  18. Elliot S. Gershon
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  19. Suzanne M. Leal
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  20. Marie Dell Aquila
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  21. Derek W. Morris
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  22. Michael Gill
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  23. Aiden Corvin
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  24. Paul A. Insel
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  25. Jon McClellan
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  26. Mary-Claire King
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  27. Maria Karayiorgou
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  28. Deborah L. Levy
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  29. Lynn E. DeLisi
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  30. Jonathan Sebat
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Contributions

V.V. and J.S. wrote the manuscript. V.V., S.M., D.M., H.-H.C., F.M., V.M., S.Y., S.M.L., P.A.I. and J.S. designed the analytical strategy and analysed the data. M.G., A.C., J.M., M.K., D.L.L., V.L-W. and L.E.D. oversaw the recruitment and clinical assessment of study participants. M.D.A. performed cytogenetic analysis. A.B., A.P. and D.M. designed genotype assays and performed genotyping. H.-H.C. and R.C. performed mRNA studies, F.M. performed biochemical studies. O.K., V.K., D.W.M., V.L.-W., L.E.D. and M.K. contributed to the interpretation of clinical patient data. J.M., M.-C.K., M.K., D.L.L., L.E.D., D.C., J.R.K. and E.S.G. contributed to the interpretation of data from genetic studies. P.A.I., L.M.I. and D.K.W. contributed to the interpretation of data from functional studies. J.S. coordinated the study.

Corresponding author

Correspondence toJonathan Sebat.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Information

The file contains Supplementary Methods, Supplementary Tables 1 and 3-7, Supplementary Figures 1-6 with legends and additional references. (PDF 1044 kb)

Supplementary Table

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Vacic, V., McCarthy, S., Malhotra, D. et al. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.Nature 471, 499–503 (2011). https://doi.org/10.1038/nature09884

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