Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia (original) (raw)
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Acknowledgements
This study was supported by a gift from Ted and Vada Stanley to the Cold Spring Harbor Laboratory, a gift to J.S. from the Beyster family foundation, NIH grants to J.S. (MH076431, HG04222), D.L.L. (MH071523), M.-C.K. (MH083989), P.A.I. (GM66232), F.M. (HL091061), D.K.W. (MH082945), M.K. (MH061399), L.E.D. (MH044245), grants to J.S., D.K.W., D.L.L. and M.-C.K from NARSAD, grants to A.C., M.G., D.M. from the Wellcome Trust (072894/Z/03/Z) and Science Foundation Ireland (08INIB1916), a career development award to D.K.W. by the Veterans Administration, and grants to D.L.L. from the Sidney R. Baer, Jr Foundation and Essel Foundation . We wish to thank the Genetic Association Information Network (GAIN), Molecular Genetics of Schizophrenia (MGS) and the Bipolar Genome Study (BiGS) for providing data for this study (investigators listed in the Supplementary Note). We wish to thank B. Trask, R. Malinow and J. Gleeson for discussions.
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Authors and Affiliations
- Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, 12824, New York, USA
Vladimir Vacic, Shane McCarthy, Dheeraj Malhotra, Abhishek Bhandari & Jonathan Sebat - Department of Computer Science, Columbia University, New York, 10027, New York, USA
Vladimir Vacic - Beyster Center for Genomics of Psychiatric Diseases, University of California, San Diego, La Jolla, 1020103, California, USA
Dheeraj Malhotra, Hsun-Hua Chou, Abhishek Bhandari & Jonathan Sebat - Department of Psychiatry, University of California, San Diego, La Jolla, 1020103, California, USA
Dheeraj Malhotra, Hsun-Hua Chou, Abhishek Bhandari, Roser Corominas, Lilia M. Iakoucheva, David K. Welsh, John R. Kelsoe & Jonathan Sebat - Department of Medicine, University of California, San Diego, La Jolla, 1020103, California, USA
Fiona Murray, Marie Dell Aquila & Paul A. Insel - Department of Pharmacology, University of California, San Diego, La Jolla, 1020103, California, USA
Fiona Murray & Paul A. Insel - Institute of Molecular Medicine and Department of Psychiatry, Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin 2, Ireland
Aine Peoples, Derek W. Morris, Michael Gill & Aiden Corvin - Seaver Autism Center, Mount Sinai School of Medicine, New York, 10029, New York, USA
Vladimir Makarov & Seungtai Yoon - Department of Psychiatry, Mount Sinai School of Medicine, New York, 10029, New York, USA
Vladimir Makarov & Seungtai Yoon - McLean Hospital, Belmont, 02478, Massachusetts, USA
Olga Krastoshevsky, Verena Krause & Deborah L. Levy - Faculty of Medicine, Universidad Andrés Bello, Santiago, Chile
Verónica Larach-Walters - Veterans Affairs San Diego Healthcare System, San Diego, 92161, California, USA
David K. Welsh & John R. Kelsoe - Center for Chronobiology, University of California, San Diego, La Jolla, 1020103, California, USA
David K. Welsh - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, 85004, Arizona, USA
David Craig - Institute for Genomic Medicine, University of California, San Diego, La Jolla, 1020103, California, USA
John R. Kelsoe & Jonathan Sebat - Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, 60637, Illinois, USA
Elliot S. Gershon - Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, 77025, Texas, USA
Suzanne M. Leal - Division of Medical Genetics, University of California, San Diego, La Jolla, 1020103, California, USA
Marie Dell Aquila - Department of Psychiatry, University of Washington, Seattle, 98195, Washington, USA
Jon McClellan - Department of Genome Sciences, University of Washington, Seattle, 98195, Washington, USA
Mary-Claire King - Department of Medicine, University of Washington, Seattle, 98195, Washington, USA
Mary-Claire King - Department of Psychiatry, Columbia University, New York, 10027, New York, USA
Maria Karayiorgou - Department of Psychiatry, Boston VA Healthcare System and Harvard Medical School, Brockton, 02301, Massachusetts, USA
Lynn E. DeLisi - Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, 1020103, California, USA
Jonathan Sebat
Authors
- Vladimir Vacic
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Contributions
V.V. and J.S. wrote the manuscript. V.V., S.M., D.M., H.-H.C., F.M., V.M., S.Y., S.M.L., P.A.I. and J.S. designed the analytical strategy and analysed the data. M.G., A.C., J.M., M.K., D.L.L., V.L-W. and L.E.D. oversaw the recruitment and clinical assessment of study participants. M.D.A. performed cytogenetic analysis. A.B., A.P. and D.M. designed genotype assays and performed genotyping. H.-H.C. and R.C. performed mRNA studies, F.M. performed biochemical studies. O.K., V.K., D.W.M., V.L.-W., L.E.D. and M.K. contributed to the interpretation of clinical patient data. J.M., M.-C.K., M.K., D.L.L., L.E.D., D.C., J.R.K. and E.S.G. contributed to the interpretation of data from genetic studies. P.A.I., L.M.I. and D.K.W. contributed to the interpretation of data from functional studies. J.S. coordinated the study.
Corresponding author
Correspondence toJonathan Sebat.
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Supplementary information
Supplementary Information
The file contains Supplementary Methods, Supplementary Tables 1 and 3-7, Supplementary Figures 1-6 with legends and additional references. (PDF 1044 kb)
Supplementary Table
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Vacic, V., McCarthy, S., Malhotra, D. et al. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.Nature 471, 499–503 (2011). https://doi.org/10.1038/nature09884
- Received: 22 October 2010
- Accepted: 28 January 2011
- Published: 23 February 2011
- Issue Date: 24 March 2011
- DOI: https://doi.org/10.1038/nature09884