- Orr, A. W., Helmke, B. P., Blackman, B. R. & Schwartz, M. A. Mechanisms of mechanotransduction. Dev. Cell 10, 11–20 (2006).
Article CAS PubMed Google Scholar
- Chen, C. S. Mechanotransduction — a field pulling together? J. Cell Sci. 121, 3285–3292 (2008).
Article CAS PubMed Google Scholar
- Geiger, B., Spatz, J. P. & Bershadsky, A. D. Environmental sensing through focal adhesions. Nature Rev. Mol. Cell Biol. 10, 21–33 (2009).
Article CAS Google Scholar
- Hahn, C. & Schwartz, M. A. Mechanotransduction in vascular physiology and atherogenesis. Nature Rev. Mol. Cell Biol. 10, 53–62 (2009).
Article CAS Google Scholar
- Lucitti, J. L. et al. Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development 134, 3317–3326 (2007).
Article CAS PubMed Google Scholar
- Yashiro, K., Shiratori, H. & Hamada, H. Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch. Nature 450, 285–288 (2007).
Article ADS CAS PubMed Google Scholar
- Discher, D. E., Janmey, P. & Wang, Y. L. Tissue cells feel and respond to the stiffness of their substrate. Science 310, 1139–1143 (2005).
Article ADS CAS PubMed Google Scholar
- Levental, K. R. et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139, 891–906 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Liu, F. et al. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J. Cell Biol. 190, 693–706 (2010).
Article CAS PubMed PubMed Central Google Scholar
- Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. Matrix elasticity directs stem cell lineage specification. Cell 126, 677–689 (2006).
Article CAS PubMed Google Scholar
- Gilbert, P. M. et al. Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture. Science 329, 1078–1081 (2010).
Article ADS CAS PubMed PubMed Central Google Scholar
- Dado, D. & Levenberg, S. Cell–scaffold mechanical interplay within engineered tissue. Semin. Cell Dev. Biol. 20, 656–664 (2009).
Article CAS PubMed Google Scholar
- Zemel, A. & Safran, S. A. Theoretical concepts and models of cellular mechanosensing. Methods Cell Biol. 98, 143–175 (2010).
Article PubMed Google Scholar
- Saratzis, A. et al. Abdominal aortic aneurysm: a review of the genetic basis. Angiology 62, 18–32 (2011).
Article CAS PubMed Google Scholar
- Hershberger, R. E., Morales, A. & Siegfried, J. D. Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals. Genet. Med. 12, 655–667 (2010).
Article CAS PubMed PubMed Central Google Scholar
- Chandrasekharan, K. & Martin, P. T. Genetic defects in muscular dystrophy. Methods Enzymol. 479, 291–322 (2010).
Article CAS PubMed Google Scholar
- Laurent, S., Boutouyrie, P. & Lacolley, P. Structural and genetic bases of arterial stiffness. Hypertension 45, 1050–1055 (2005).
Article CAS PubMed Google Scholar
- Yu, H., Mouw, J. K. & Weaver, V. M. Forcing form and function: biomechanical regulation of tumor evolution. Trends Cell Biol. 21, 47–56 (2011).
Article PubMed Google Scholar
- Schwartz, M. A. & DeSimone, D. W. Cell adhesion receptors in mechanotransduction. Curr. Opin. Cell Biol. 20, 551–556 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Gardel, M. L., Kasza, K. E., Brangwynne, C. P., Liu, J. & Weitz, D. A. Chapter 19 Mechanical response of cytoskeletal networks. Methods Cell Biol. 89, 487–519 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Helmke, B. P., Rosen, A. B. & Davies, P. F. Mapping mechanical strain of an endogenous cytoskeletal network in living endothelial cells. Biophys. J. 84, 2691–2699 (2003).
Article CAS PubMed PubMed Central Google Scholar
- Tzima, E. et al. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 437, 426–431 (2005). This paper identifies a crucial complex, consisting of PECAM1, VE-cadherin and VEGFR-2, in the pathway leading to integrin activation by shear flow.
Article ADS CAS PubMed Google Scholar
- Matthews, B. D., Overby, D. R., Mannix, R. & Ingber, D. E. Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J. Cell Sci. 119, 508–518 (2006).
Article CAS PubMed Google Scholar
- Na, S. et al. Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proc. Natl Acad. Sci. USA 105, 6626–6631 (2008).
Article ADS CAS PubMed PubMed Central Google Scholar
- Wang, N. & Stamenovic, D. Contribution of intermediate filaments to cell stiffness, stiffening, and growth. Am. J. Physiol. Cell Physiol. 279, C188–C194 (2000).
Article CAS PubMed Google Scholar
- Hayakawa, K., Tatsumi, H. & Sokabe, M. Actin stress fibers transmit and focus force to activate mechanosensitive channels. J. Cell Sci. 121, 496–503 (2008).
Article CAS PubMed Google Scholar
- Poh, Y. C. et al. Rapid activation of Rac GTPase in living cells by force is independent of Src. PLoS ONE 4, e7886 (2009).
Article ADS PubMed PubMed Central CAS Google Scholar
- Sukharev, S., Betanzos, M., Chiang, C. S. & Guy, H. R. The gating mechanism of the large mechanosensitive channel MscL. Nature 409, 720–724 (2001).
Article ADS CAS PubMed Google Scholar
- Árnadóttir, J. & Chalfie, M. Eukaryotic mechanosensitive channels. Annu. Rev. Biophys. 39, 111–137 (2010).
Article PubMed CAS Google Scholar
- Zhong, C. et al. Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly. J. Cell Biol. 141, 539–551 (1998).
Article CAS PubMed PubMed Central Google Scholar
- Oberhauser, A. F., Badilla-Fernandez, C., Carrion-Vazquez, M. & Fernandez, J. M. The mechanical hierarchies of fibronectin observed with single-molecule AFM. J. Mol. Biol. 319, 433–447 (2002).
Article CAS PubMed Google Scholar
- Smith, M. L. et al. Force-induced unfolding of fibronectin in the extracellular matrix of living cells. PLoS Biol. 5, e268 (2007).
Article PubMed PubMed Central CAS Google Scholar
- Ziegler, W. H., Gingras, A. R., Critchley, D. R. & Emsley, J. Integrin connections to the cytoskeleton through talin and vinculin. Biochem. Soc. Trans. 36, 235–239 (2008).
Article CAS PubMed Google Scholar
- del Rio, A. et al. Stretching single talin rod molecules activates vinculin binding. Science 323, 638–641 (2009). This study demonstrates force-induced binding of vinculin to cryptic sites in talin at the single molecule level.
Article ADS CAS PubMed Google Scholar
- Zhang, X. et al. Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nature Cell Biol. 10, 1062–1068 (2008).
Article CAS PubMed Google Scholar
- Defilippi, P., Di Stefano, P. & Cabodi, S. p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol. 16, 257–263 (2006).
Article CAS PubMed Google Scholar
- Tamada, M., Sheetz, M. P. & Sawada, Y. Activation of a signaling cascade by cytoskeleton stretch. Dev. Cell 7, 709–718 (2004).
Article CAS PubMed Google Scholar
- Sawada, Y. et al. Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase. J. Cell Sci. 114, 1221–1227 (2001).
Article CAS PubMed Google Scholar
- Sawada, Y. & Sheetz, M. P. Force transduction by Triton cytoskeletons. J. Cell Biol. 156, 609–615 (2002).
Article CAS PubMed PubMed Central Google Scholar
- Sawada, Y. et al. Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell 127, 1015–1026 (2006). This study shows that stretching of p130 Cas leads to the exposure of tyrosine residues, which can be phosphorylated to affect signalling pathways.
Article CAS PubMed PubMed Central Google Scholar
- Parsons, J. T., Horwitz, A. R. & Schwartz, M. A. Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nature Rev. Mol. Cell Biol. 11, 633–643 (2010).
Article CAS Google Scholar
- Asparuhova, M. B., Gelman, L. & Chiquet, M. Role of the actin cytoskeleton in tuning cellular responses to external mechanical stress. Scand. J. Med. Sci. Sports 19, 490–499 (2009).
Article CAS PubMed Google Scholar
- Olson, E. N. & Nordheim, A. Linking actin dynamics and gene transcription to drive cellular motile functions. Nature Rev. Mol. Cell Biol. 11, 353–365 (2010).
Article CAS Google Scholar
- Mallion, J. M., Baguet, J. P., Siche, J. P., Tremel, F. & De Gaudemaris, R. Left ventricular hypertrophy and arterial hypertrophy. Adv. Exp. Med. Biol. 432, 123–133 (1997).
Article CAS PubMed Google Scholar
- Vogel, V. Mechanotransduction involving multimodular proteins: converting force into biochemical signals. Annu. Rev. Biophys. Biomol. Struct. 35, 459–488 (2006).
Article CAS PubMed Google Scholar
- Zheng, W., Christensen, L. P. & Tomanek, R. J. Differential effects of cyclic and static stretch on coronary microvascular endothelial cell receptors and vasculogenic/angiogenic responses. Am. J. Physiol. Heart Circ. Physiol. 295, H794–H800 (2008). This study provides evidence that statically and dynamically applied stretches lead to the activation of distinct pathways in stretched endothelial cells.
Article CAS PubMed PubMed Central Google Scholar
- Lehoux, S., Esposito, B., Merval, R. & Tedgui, A. Differential regulation of vascular focal adhesion kinase by steady stretch and pulsatility. Circulation 111, 643–649 (2005).
Article CAS PubMed Google Scholar
- Hsu, H. J., Lee, C. F. & Kaunas, R. A dynamic stochastic model of frequency-dependent stress fiber alignment induced by cyclic stretch. PLoS ONE 4, e4853 (2009).
Article ADS PubMed PubMed Central CAS Google Scholar
- Liu, B. et al. Role of cyclic strain frequency in regulating the alignment of vascular smooth muscle cells in vitro . Biophys J. 94, 1497–1507 (2008).
Article ADS CAS PubMed Google Scholar
- Gelfand, B. D., Epstein, F. H. & Blackman, B. R. Spatial and spectral heterogeneity of time-varying shear stress profiles in the carotid bifurcation by phase-contrast MRI. J. Magn. Reson. Imaging 24, 1386–1392 (2006).
Article PubMed Google Scholar
- Dancu, M. B. & Tarbell, J. M. Large negative stress phase angle (SPA) attenuates nitric oxide production in bovine aortic endothelial cells. J. Biomech. Eng. 128, 329–334 (2006).
Article PubMed Google Scholar
- Wehrle-Haller, B. Analysis of integrin dynamics by fluorescence recovery after photobleaching. Methods Mol. Biol. 370, 173–201 (2007).
Article CAS PubMed Google Scholar
- Hu, K., Ji, L., Applegate, K. T., Danuser, G. & Waterman-Storer, C. M. Differential transmission of actin motion within focal adhesions. Science 315, 111–115 (2007).
Article ADS CAS PubMed Google Scholar
- Brown, C. M. et al. Probing the integrin–actin linkage using high-resolution protein velocity mapping. J. Cell Sci. 119, 5204–5214 (2006).
Article CAS PubMed Google Scholar
- Maruthamuthu, V., Aratyn-Schaus, Y. & Gardel, M. L. Conserved F-actin dynamics and force transmission at cell adhesions. Curr. Opin. Cell Biol. 22, 583–588 (2010).
Article CAS PubMed PubMed Central Google Scholar
- Liu, Z. et al. Mechanical tugging force regulates the size of cell–cell junctions. Proc. Natl Acad. Sci. USA 107, 9944–9949 (2010).
Article ADS CAS PubMed PubMed Central Google Scholar
- Maruthamuthu, V., Sabass, B., Schwarz, U. S. & Gardel, M. L. Cell–ECM traction force modulates endogenous tension at cell–cell contacts. Proc. Natl Acad. Sci. USA 108, 4708–4713 (2011).
Article ADS CAS PubMed PubMed Central Google Scholar
- Mège, R. M., Gavard, J. & Lambert, M. Regulation of cell–cell junctions by the cytoskeleton. Curr. Opin. Cell Biol. 18, 541–548 (2006).
Article PubMed CAS Google Scholar
- Ladoux, B. et al. Strength dependence of cadherin-mediated adhesions. Biophys. J. 98, 534–542 (2010).
Article CAS PubMed PubMed Central Google Scholar
- Kametani, Y. & Takeichi, M. Basal-to-apical cadherin flow at cell junctions. Nature Cell Biol. 9, 92–98 (2007).
Article CAS PubMed Google Scholar
- Riveline, D. et al. Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J. Cell Biol. 153, 1175–1186 (2001).
Article CAS PubMed PubMed Central Google Scholar
- le Duc, Q. et al. Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J. Cell Biol. 189, 1107–1115 (2010).
Article CAS PubMed PubMed Central Google Scholar
- Evans, E. A. & Calderwood, D. A. Forces and bond dynamics in cell adhesion. Science 316, 1148–1153 (2007).
Article ADS CAS PubMed Google Scholar
- Thomas, W. E., Vogel, V. & Sokurenko, E. Biophysics of catch bonds. Annu. Rev. Biophys. 37, 399–416 (2008).
Article CAS PubMed Google Scholar
- Bustamante, C., Chemla, Y. R., Forde, N. R. & Izhaky, D. Mechanical processes in biochemistry. Annu. Rev. Biochem. 73, 705–748 (2004).
Article CAS PubMed Google Scholar
- Ferrer, J. M. et al. Measuring molecular rupture forces between single actin filaments and actin-binding proteins. Proc. Natl Acad. Sci. USA 105, 9221–9226 (2008).
Article ADS CAS PubMed PubMed Central Google Scholar
- Bruinsma, R. Theory of force regulation by nascent adhesion sites. Biophys. J. 89, 87–94 (2005).
Article ADS CAS PubMed PubMed Central Google Scholar
- Chan, C. E. & Odde, D. J. Traction dynamics of filopodia on compliant substrates. Science 322, 1687–1691 (2008). This study proposes and validates a model describing rigidity sensitive FA dynamics in terms of force-activated protein dissociation.
Article ADS CAS PubMed Google Scholar
- Li, Y., Bhimalapuram, P. & Dinner, A. R. Model for how retrograde actin flow regulates adhesion traction stresses. J. Phys. Condens. Matter 22, 194113 (2010).
Article ADS PubMed CAS Google Scholar
- Gardel, M. L. et al. Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. J. Cell Biol. 183, 999–1005 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Schmidt, C. E., Horwitz, A. F., Lauffenburger, D. A. & Sheetz, M. P. Integrin–cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated. J. Cell Biol. 123, 977–991 (1993).
Article CAS PubMed Google Scholar
- Grashoff, C. et al. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature 466, 263–266 (2010). This paper reports a biosensor that measures forces across specific proteins in dynamic FAs and shows that molecular tension across vinculin correlates with FA strengthening.
Article ADS CAS PubMed PubMed Central Google Scholar
- Miyata, H., Yasuda, R. & Kinosita, K. Jr. Strength and lifetime of the bond between actin and skeletal muscle α-actinin studied with an optical trapping technique. Biochim. Biophys. Acta 1290, 83–88 (1996).
Article PubMed Google Scholar
- Kong, F., Garcia, A. J., Mould, A. P., Humphries, M. J. & Zhu, C. Demonstration of catch bonds between an integrin and its ligand. J. Cell Biol. 185, 1275–1284 (2009). This study shows that the linkage between α 5 β 1 integrin and fibronectin acts like a catch bond at the single molecule level.
Article CAS PubMed PubMed Central Google Scholar
- Friedland, J. C., Lee, M. H. & Boettiger, D. Mechanically activated integrin switch controls α5β1 function. Science 323, 642–644 (2009). This study shows that force and increased extracellular rigidity switch α 5 β 1 integrin between a relaxed and a tensioned state that is required for mechanically induced focal adhesion kinase signalling.
Article ADS CAS PubMed Google Scholar
- Guo, B. & Guilford, W. H. Mechanics of actomyosin bonds in different nucleotide states are tuned to muscle contraction. Proc. Natl Acad. Sci. USA 103, 9844–9849 (2006).
Article ADS CAS PubMed PubMed Central Google Scholar
- Hoffman, B. D. & Crocker, J. C. Cell mechanics: dissecting the physical responses of cells to force. Annu. Rev. Biomed. Eng. 11, 259–288 (2009).
Article CAS PubMed Google Scholar
- Trepat, X. et al. Universal physical responses to stretch in the living cell. Nature 447, 592–595 (2007).
Article ADS CAS PubMed PubMed Central Google Scholar
- Gardel, M. L. et al. Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Proc. Natl Acad. Sci. USA 103, 1762–1767 (2006).
Article ADS CAS PubMed PubMed Central Google Scholar
- Lee, H., Ferrer, J. M., Lang, M. J. & Kamm, R. D. Molecular origin of strain softening in cross-linked F-actin networks. Phys. Rev. E 82, 011919 (2010).
Article ADS CAS Google Scholar
- Chaudhuri, O., Parekh, S. H. & Fletcher, D. A. Reversible stress softening of actin networks. Nature 445, 295–298 (2007).
Article ADS CAS PubMed PubMed Central Google Scholar
- Chen, C. et al. Fluidization and resolidification of the human bladder smooth muscle cell in response to transient stretch. PLoS ONE 5, e12035 (2010).
Article ADS PubMed PubMed Central CAS Google Scholar
- Shafrir, Y. & Forgacs, G. Mechanotransduction through the cytoskeleton. Am. J. Physiol. Cell Physiol. 282, C479–C486 (2002).
Article CAS PubMed Google Scholar
- Mack, P. J., Kaazempur-Mofrad, M. R., Karcher, H., Lee, R. T. & Kamm, R. D. Force-induced focal adhesion translocation: effects of force amplitude and frequency. Am. J. Physiol. Cell Physiol. 287, C954–C962 (2004).
Article CAS PubMed Google Scholar
- Hu, S. & Wang, N. Control of stress propagation in the cytoplasm by prestress and loading frequency. Mol. Cell. Biomech. 3, 49–60 (2006).
PubMed Google Scholar
- Jiang, G., Huang, A. H., Cai, Y., Tanase, M. & Sheetz, M. P. Rigidity sensing at the leading edge through α v β 3 integrins and RPTPa. Biophys. J. 90, 1804–1809 (2006).
Article ADS CAS PubMed Google Scholar
- Smith, M. A. et al. A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Dev. Cell 19, 365–376 (2010).
Article CAS PubMed PubMed Central Google Scholar
- Wojtowicz, A. et al. Zyxin mediation of stretch-induced gene expression in human endothelial cells. Circ. Res. 107, 898–902 (2010).
Article CAS PubMed Google Scholar
- Chiquet, M., Gelman, L., Lutz, R. & Maier, S. From mechanotransduction to extracellular matrix gene expression in fibroblasts. Biochim. Biophys. Acta 1793, 911–920 (2009).
Article CAS PubMed Google Scholar
- Katsumi, A. et al. Effects of cell tension on the small GTPase Rac. J. Cell Biol. 158, 153–164 (2002).
Article CAS PubMed PubMed Central Google Scholar
- Kanda, K. & Matsuda, T. Behavior of arterial-wall cells cultured on periodically stretched substrates. Cell Transplant. 2, 475–484 (1993).
Article CAS PubMed Google Scholar
- De, R., Zemel, A. & Safran, S. A. Dynamics of cell orientation. Nature Phys. 3, 655–659 (2007). This theory-based study suggests how cytoskeletal dynamics affect the ability of cells to align to dynamically applied stretches.
Article ADS CAS Google Scholar
- Kaunas, R., Nguyen, P., Usami, S. & Chien, S. Cooperative effects of Rho and mechanical stretch on stress fiber organization. Proc. Natl Acad. Sci. USA 102, 15895–15900 (2005).
Article ADS CAS PubMed PubMed Central Google Scholar
- Prezhdo, O. V. & Pereverzev, Y. V. Theoretical aspects of the biological catch bond. Acc. Chem. Res. 42, 693–703 (2009).
Article CAS PubMed Google Scholar
- Haga, J. H., Li, Y. S. & Chien, S. Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells. J. Biomech. 40, 947–960 (2007).
Article PubMed Google Scholar