TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation (original) (raw)

References

1. Anthony, R. M., Rutitzky, L. I., Urban, J. F., Jr, Stadecker, M. J. & Gause, W. C. Protective immune mechanisms in helminth infection. Nature Rev. Immunol. 7, 975–987 (2007)
   Article CAS Google Scholar
2. Umetsu, D. T., McIntire, J. J., Akbari, O., Macaubas, C. & DeKruyff, R. H. Asthma: an epidemic of dysregulated immunity. Nature Immunol. 3, 715–720 (2002)
   Article CAS Google Scholar
3. Harada, M. et al. TSLP promoter polymorphisms are associated with susceptibility to bronchial asthma. Am. J. Respir. Cell Mol. Biol. 44, 787–793 (2011)
   Article CAS Google Scholar
4. Sherrill, J. D. et al. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J. Allergy Clin. Immunol. 126, 160–5e3 (2010)
   Article CAS Google Scholar
5. Rothenberg, M. E. et al. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nature Genet. 42, 289–291 (2010)
   Article CAS Google Scholar
6. Hunninghake, G. M. et al. TSLP polymorphisms are associated with asthma in a sex-specific fashion. Allergy 65, 1566–1575 (2010)
   Article Google Scholar
7. Ying, S. et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J. Immunol. 174, 8183–8190 (2005)
   Article CAS Google Scholar
8. Al-Shami, A. et al. A role for thymic stromal lymphopoietin in CD4+ T cell development. J. Exp. Med. 200, 159–168 (2004)
   Article CAS Google Scholar
9. Ito, T. et al. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J. Exp. Med. 202, 1213–1223 (2005)
   Article CAS Google Scholar
10. Taylor, B. C. et al. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J. Exp. Med. 206, 655–667 (2009)
    Article CAS Google Scholar
11. Mou, Z. et al. Overexpression of thymic stromal lymphopoietin in allergic rhinitis. Acta Otolaryngol. (Stockh.) 129, 297–301 (2009)
    Article CAS Google Scholar
12. Soumelis, V. et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nature Immunol. 3, 673–680 (2002)
    Article CAS Google Scholar
13. Ziegler, S. F. & Artis, D. Sensing the outside world: TSLP regulates barrier immunity. Nature Immunol. 11, 289–293 (2010)
    Article CAS Google Scholar
14. Sebestyén, M. G. et al. Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules. J. Gene Med. 8, 852–873 (2006)
    Article Google Scholar
15. Perrigoue, J. G. et al. MHC class II-dependent basophil-CD4+ T cell interactions promote TH2 cytokine-dependent immunity. Nature Immunol. 10, 697–705 (2009)
    Article CAS Google Scholar
16. Sokol, C. L. et al. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nature Immunol. 10, 713–720 (2009)
    Article CAS Google Scholar
17. Yoshimoto, T. et al. Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nature Immunol. 10, 706–712 (2009)
    Article CAS Google Scholar
18. Hammad, H. et al. Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J. Exp. Med. 207, 2097–2111 (2010)
    Article CAS Google Scholar
19. Ohnmacht, C. et al. Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 33, 364–374 (2010)
    Article CAS Google Scholar
20. Tang, H. et al. The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nature Immunol. 11, 608–617 (2010)
    Article CAS Google Scholar
21. Zhou, B. et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nature Immunol. 6, 1047–1053 (2005)
    Article CAS Google Scholar
22. Gessner, A., Mohrs, K. & Mohrs, M. Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J. Immunol. 174, 1063–1072 (2005)
    Article CAS Google Scholar
23. Iwasaki, H. & Akashi, K. Myeloid lineage commitment from the hematopoietic stem cell. Immunity 26, 726–740 (2007)
    Article CAS Google Scholar
24. Lantz, C. S. et al. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature 392, 90–93 (1998)
    Article ADS CAS Google Scholar
25. Scott, C. L. et al. Reassessment of interactions between hematopoietic receptors using common β-chain and interleukin-3-specific receptor β-chain-null cells: no evidence of functional interactions with receptors for erythropoietin, granulocyte colony-stimulating factor, or stem cell factor. Blood 96, 1588–1590 (2000)
    CAS PubMed Google Scholar
26. Haining, W. N. & Wherry, E. J. Integrating genomic signatures for immunologic discovery. Immunity 32, 152–161 (2010)
    Article CAS Google Scholar
27. Lenox, L. E. et al. Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis. J. Allergy Clin. Immunol. 124, 1088–1098 (2009)
    Article CAS Google Scholar
28. Siracusa, M. C., Perrigoue, J. G., Comeau, M. R. & Artis, D. New paradigms in basophil development, regulation and function. Immunol. Cell Biol. 88, 275–284 (2010)
    Article Google Scholar
29. Li, M. et al. Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin. J. Invest. Dermatol. 129, 498–502 (2009)
    Article CAS Google Scholar
30. Sawaguchi, M. et al. Basophils and mast cells differently regulate allergic response; in vivo demonstration by diphtheria toxin based deletion system. Int. Congress Immunol. WS/PP-043–04. (2011)
31. Zaph, C. et al. Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis. Nature 446, 552–556 (2007)
    Article ADS CAS Google Scholar
32. Nair, M. G. et al. Goblet cell-derived resistin-like molecule β augments CD4+ T cell production of IFN-γ and infection-induced intestinal inflammation. J. Immunol. 181, 4709–4715 (2008)
    Article CAS Google Scholar

Download references

Acknowledgements

We thank members of the Artis laboratory for critical reading of the manuscript, A. Budelsky, T. Martin, B.-R. Park Yoon, J. Bigler and M. Timour (Amgen) for assistance with experiments and microarrays and the University of Pennsylvania flow cytometry core for assistance with sorting. Work in the Artis laboratory is supported by the National Institutes of Health (AI61570, AI74878, AI87990 and AI083480 (to D.A.), F32 fellowship AI085828 (to M.C.S.), F31 training grant GM082187 (to S.A.S), T32 training grant AI060516 (to D.A.H.)) and the Burroughs Wellcome Fund (to D.A.).

Author information

Authors and Affiliations

1. Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA
   Mark C. Siracusa, Steven A. Saenz, David A. Hill, Brian S. Kim, Travis A. Doering, E. John Wherry & David Artis
2. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA
   Mark C. Siracusa, Steven A. Saenz, David A. Hill, Brian S. Kim, Travis A. Doering, E. John Wherry & David Artis
3. and Immunology Department, Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, University of Washington School of Medicine, Seattle, 98195, Washington, USA
   Mark B. Headley & Steven F. Ziegler
4. Inflammation Research, Amgen Inc., Seattle, 98119, Washington, USA
   Heidi K. Jessup, Lori A. Siegel & Michael R. Comeau
5. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA
   Taku Kambayashi
6. Division of Allergy and Immunology, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA
   Emily C. Dudek, Antonella Cianferoni & Jonathan M. Spergel
7. Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama 230-0045, Japan
   Masato Kubo
8. Division of Molecular Pathology, Research Institute for Biological Science, Tokyo University of Science, Chiba 278-0022, Japan
   Masato Kubo
9. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA
   David Artis

Authors

1. Mark C. Siracusa
   You can also search for this author inPubMed Google Scholar
2. Steven A. Saenz
   You can also search for this author inPubMed Google Scholar
3. David A. Hill
   You can also search for this author inPubMed Google Scholar
4. Brian S. Kim
   You can also search for this author inPubMed Google Scholar
5. Mark B. Headley
   You can also search for this author inPubMed Google Scholar
6. Travis A. Doering
   You can also search for this author inPubMed Google Scholar
7. E. John Wherry
   You can also search for this author inPubMed Google Scholar
8. Heidi K. Jessup
   You can also search for this author inPubMed Google Scholar
9. Lori A. Siegel
   You can also search for this author inPubMed Google Scholar
10. Taku Kambayashi
    You can also search for this author inPubMed Google Scholar
11. Emily C. Dudek
    You can also search for this author inPubMed Google Scholar
12. Masato Kubo
    You can also search for this author inPubMed Google Scholar
13. Antonella Cianferoni
    You can also search for this author inPubMed Google Scholar
14. Jonathan M. Spergel
    You can also search for this author inPubMed Google Scholar
15. Steven F. Ziegler
    You can also search for this author inPubMed Google Scholar
16. Michael R. Comeau
    You can also search for this author inPubMed Google Scholar
17. David Artis
    You can also search for this author inPubMed Google Scholar

Contributions

M.C.S., S.A.S., D.A.H., B.S.K., M.B.H., H.K.J., L.A.S., M.R.C. and D.A. designed and performed the research. S.F.Z., T.K. and M.K. provided reagents. E.C.D., A.C. and J.M.S. collected and provided human samples. M.C.S., S.A.S., D.A.H., B.S.K., T.A.D., E.J.W and D.A. analysed the data. M.C.S. and D.A. wrote the paper.

Corresponding author

Correspondence toDavid Artis.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

PowerPoint slides

Rights and permissions

About this article

Cite this article

Siracusa, M., Saenz, S., Hill, D. et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.Nature 477, 229–233 (2011). https://doi.org/10.1038/nature10329

Download citation

• Received: 24 May 2011
• Accepted: 27 June 2011
• Published: 14 August 2011
• Issue Date: 08 September 2011
• DOI: https://doi.org/10.1038/nature10329