Ebola virus entry requires the cholesterol transporter Niemann–Pick C1 (original) (raw)

• Feldmann, H. & Geisbert, T. W. Ebola haemorrhagic fever. Lancet 377, 849–862 (2010)
  Article Google Scholar
• Lee, J. E. & Saphire, E. O. Ebolavirus glycoprotein structure and mechanism of entry. Future Virol. 4, 621–635 (2009)
  Article CAS PubMed PubMed Central Google Scholar
• Schornberg, K. et al. Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein. J. Virol. 80, 4174–4178 (2006)
  Article CAS PubMed PubMed Central Google Scholar
• Kuhn, J. H. et al. Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor. J. Biol. Chem. 281, 15951–15958 (2006)
  Article CAS PubMed Google Scholar
• Chandran, K., Sullivan, N. J., Felbor, U., Whelan, S. P. & Cunningham, J. M. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 308, 1643–1645 (2005)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Nickerson, D. P., Brett, C. L. & Merz, A. J. Vps-C complexes: gatekeepers of endolysosomal traffic. Curr. Opin. Cell Biol. 21, 543–551 (2009)
  Article CAS PubMed PubMed Central Google Scholar
• Carstea, E. D. et al. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science 277, 228–231 (1997)
  Article CAS PubMed Google Scholar
• Carette, J. E. et al. Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nature Biotechnol. 29, 542–546 (2011)
  Article CAS Google Scholar
• Carette, J. E. et al. Haploid genetic screens in human cells identify host factors used by pathogens. Science 326, 1231–1235 (2009)
  Article ADS CAS PubMed Google Scholar
• Wong, A. C., Sandesara, R. G., Mulherkar, N., Whelan, S. P. & Chandran, K. A forward genetic strategy reveals destabilizing mutations in the Ebolavirus glycoprotein that alter its protease dependence during cell entry. J. Virol. 84, 163–175 (2010)
  Article CAS PubMed Google Scholar
• Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861–872 (2007)
  Article CAS PubMed Google Scholar
• Poteryaev, D., Datta, S., Ackema, K., Zerial, M. & Spang, A. Identification of the switch in early-to-late endosome transition. Cell 141, 497–508 (2010)
  Article CAS PubMed Google Scholar
• Rink, J., Ghigo, E., Kalaidzidis, Y. & Zerial, M. Rab conversion as a mechanism of progression from early to late endosomes. Cell 122, 735–749 (2005)
  Article CAS PubMed Google Scholar
• Sbrissa, D. et al. Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. J. Biol. Chem. 282, 23878–23891 (2007)
  Article CAS PubMed Google Scholar
• Dell’Angelica, E. C. The building BLOC(k)s of lysosomes and related organelles. Curr. Opin. Cell Biol. 16, 458–464 (2004)
  Article PubMed Google Scholar
• Tiede, S. et al. Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase. Nature Med. 11, 1109–1112 (2005)
  Article CAS PubMed Google Scholar
• Goldman, S. D. & Krise, J. P. Niemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo. J. Biol. Chem. 285, 4983–4994 (2010)
  Article CAS PubMed Google Scholar
• Lloyd-Evans, E. et al. Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nature Med. 14, 1247–1255 (2008)
  Article CAS PubMed Google Scholar
• Tang, Y. Y., Leao, I. C., Coleman, E. M., Broughton, R. S. & Hildreth, J. E. K. Deficiency of Niemann-Pick type C-1 protein impairs release of human immunodeficiency virus type 1 and results in Gag accumulation in late endosomal/lysosomal compartments. J. Virol. 83, 7982–7995 (2009)
  Article CAS PubMed PubMed Central Google Scholar
• Naureckiene, S. et al. Identification of HE1 as the second gene of Niemann-Pick C disease. Science 290, 2298–2301 (2000)
  Article ADS CAS PubMed Google Scholar
• Takada, A. et al. A system for functional analysis of Ebola virus glycoprotein. Proc. Natl Acad. Sci. USA 94, 14764–14769 (1997)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Wool-Lewis, R. J. & Bates, P. Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines. J. Virol. 72, 3155–3160 (1998)
  CAS PubMed PubMed Central Google Scholar
• Cenedella, R. J. Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids 44, 477–487 (2009)
  Article CAS PubMed Google Scholar
• Rodriguez-Lafrasse, C. et al. Abnormal cholesterol metabolism in imipramine-treated fibroblast cultures. Similarities with Niemann-Pick type C disease. Biochim Biophys Acta 1043, 123–128 (1990)
  Article CAS PubMed Google Scholar
• Sobo, K. et al. Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking. Plos One 2, e851 (2007)
  Article ADS PubMed PubMed Central Google Scholar
• Kondratowicz, A. S. et al. T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc. Natl Acad. Sci. USA. 108, 8426–8431 (2011)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Alvarez, C. P. et al. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans . J. Virol. 76, 6841–6844 (2002)
  Article CAS PubMed PubMed Central Google Scholar
• Saeed, M. F., Kolokoltsov, A. A., Albrecht, T. & Davey, R. A. Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes. PLoS Pathog . 6, http://dx.doi.org/10.1371/journal.ppat.1001110 (2010)
• Nanbo, A. et al. Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner. PLoS Pathog . 6, http://dx.doi.org/10.1371/journal.ppat.1001121 (2010)
• Cruz, J. C., Sugii, S., Yu, C. & Chang, T. Y. Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol. J. Biol. Chem. 275, 4013–4021 (2000)
  Article CAS PubMed Google Scholar
• Geisbert, T. W. et al. Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection. Am. J. Pathol. 163, 2347–2370 (2003)
  Article CAS PubMed PubMed Central Google Scholar
• Geisbert, T. W. et al. Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells. Am. J. Pathol. 163, 2371–2382 (2003)
  Article CAS PubMed PubMed Central Google Scholar
• Whelan, S. P., Barr, J. N. & Wertz, G. W. Identification of a minimal size requirement for termination of vesicular stomatitis virus mRNA: implications for the mechanism of transcription. J. Virol. 74, 8268–8276 (2000)
  Article CAS PubMed PubMed Central Google Scholar
• Whelan, S. P., Ball, L. A., Barr, J. N. & Wertz, G. T. Efficient recovery of infectious vesicular stomatitis virus entirely from cDNA clones. Proc. Natl Acad. Sci. USA 92, 8388–8392 (1995)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Takada, A., Watanabe, S., Okazaki, K., Kida, H. & Kawaoka, Y. Infectivity-enhancing antibodies to Ebola virus glycoprotein. J. Virol. 75, 2324–2330 (2001)
  Article CAS PubMed PubMed Central Google Scholar
• Carette, J. E. et al. Generation of iPSCs from cultured human malignant cells. Blood 115, 4039–4042 (2010)
  Article CAS PubMed PubMed Central Google Scholar
• Morgenstern, J. P. & Land, H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18, 3587–3596 (1990)
  Article CAS PubMed PubMed Central Google Scholar
• Pentchev, P. G. et al. The cholesterol storage disorder of the mutant BALB/c mouse. A primary genetic lesion closely linked to defective esterification of exogenously derived cholesterol and its relationship to human type C Niemann-Pick disease. J. Biol. Chem. 261, 2772–2777 (1986)
  CAS PubMed Google Scholar
• Ebert, D. H., Deussing, J., Peters, C. & Dermody, T. S. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J. Biol. Chem. 277, 24609–24617 (2002)
  Article CAS PubMed Google Scholar
• Blum, G. et al. Dynamic imaging of protease activity with fluorescently quenched activity-based probes. Nature Chem. Biol. 1, 203–209 (2005)
  Article CAS Google Scholar
• Cureton, D. K., Massol, R. H., Saffarian, S., Kirchhausen, T. L. & Whelan, S. P. Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. PLoS Pathog. 5, e1000394 (2009)
  Article PubMed PubMed Central Google Scholar
• Ehrlich, M. et al. Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell 118, 591–605 (2004)
  Article CAS PubMed Google Scholar
• Lefrancois, L. & Lyles, D. S. The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus. I. Analysis of neutralizing epitopes with monoclonal antibodies. Virology 121, 157–167 (1982)
  Article CAS PubMed Google Scholar
• Wilson, J. A. et al. Epitopes involved in antibody-mediated protection from Ebola virus. Science 287, 1664–1666 (2000)
  Article ADS CAS PubMed Google Scholar
• Maruyama, T. et al. Ebola virus can be effectively neutralized by antibody produced in natural human infection. J. Virol. 73, 6024–6030 (1999)
  CAS PubMed PubMed Central Google Scholar
• Bray, M., Davis, K., Geisbert, T., Schmaljohn, C. & Huggins, J. A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J. Infect. Dis. 178, 651–661 (1998)
  Article CAS PubMed Google Scholar
• Warfield, K. L. et al. Development of a model for marburgvirus based on severe-combined immunodeficiency mice. Virol. J. 4, 108 (2007)
  Article PubMed PubMed Central Google Scholar
• Muhlberger, E., Weik, M., Volchkov, V. E., Klenk, H. D. & Becker, S. Comparison of the transcription and replication strategies of Marburg virus and Ebola virus by using artificial replication systems. J. Virol. 73, 2333–2342 (1999)
  CAS PubMed PubMed Central Google Scholar
• Kranzusch, P. J. et al. Assembly of a functional Machupo virus polymerase complex. Proc. Natl Acad Sci USA 107, 20069–20074 (2010)
  Article ADS CAS PubMed PubMed Central Google Scholar