FOXO3A directs a protective autophagy program in haematopoietic stem cells (original) (raw)

• Rando, T. A. Stem cells, ageing and the quest for immortality. Nature 441, 1080–1086 (2006)
  Article ADS CAS Google Scholar
• Orkin, S. H. & Zon, L. I. Hematopoiesis: an evolving paradigm for stem cell biology. Cell 132, 631–644 (2008)
  Article CAS Google Scholar
• Rossi, D. J., Jamieson, C. H. M. & Weissman, I. L. Stems cells and the pathways to aging and cancer. Cell 132, 681–696 (2008)
  Article CAS Google Scholar
• Warr, M. R., Pietras, E. M. & Passegué, E. Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies. Wiley Interdiscip. Rev. Syst. Biol. Med. 3, 681–701 (2011)
  Article CAS Google Scholar
• Ferraro, E. & Cecconi, F. Autophagic and apoptotic response to stress signals in mammalian cells. Arch. Biochem. Biophys. 462, 210–219 (2007)
  Article CAS Google Scholar
• He, C. & Klionsky, D. J. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 43, 67–93 (2009)
  Article CAS Google Scholar
• Danial, N. N. & Korsmeyer, S. J. Cell death: critical control points. Cell 116, 205–219 (2004)
  Article CAS Google Scholar
• Maiuri, M. C., Zalckvar, E., Kimchi, A. & Kroemer, G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nature Rev. Mol. Cell Biol. 8, 741–752 (2007)
  Article CAS Google Scholar
• Debnath, J., Baehrecke, E. H. & Kroemer, G. Does autophagy contribute to cell death? Autophagy 1, 66–74 (2005)
  Article CAS Google Scholar
• Oguro, H. & Iwana, A. Life and death in hematopoietic stem cells. Curr. Opin. Immunol. 19, 503–509 (2007)
  Article CAS Google Scholar
• Levine, B., Mizushima, N. & Virgin, H. W. Autophagy in immunity and inflammation. Nature 469, 323–335 (2011)
  Article ADS CAS Google Scholar
• Pua, H. H., Dzhagalov, I., Chuck, M., Mizushima, N. & He, Y. W. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J. Exp. Med. 204, 25–31 (2007)
  Article CAS Google Scholar
• Miller, B. C. et al. The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy 4, 309–314 (2008)
  Article CAS Google Scholar
• Kundu, M. et al. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 112, 1493–1502 (2008)
  Article CAS Google Scholar
• Mortensen, M. et al. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo . Proc. Natl Acad. Sci. USA 107, 832–837 (2010)
  Article ADS CAS Google Scholar
• Liu, F. et al. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood 116, 4806–4814 (2010)
  Article CAS Google Scholar
• Mortensen, M. et al. The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J. Exp. Med. 208, 455–467 (2011)
  Article CAS Google Scholar
• Pietras, E. M., Warr, M. R. & Passegué, E. Cell cycle regulation in hematopoietic stem cells. J. Cell Biol. 195, 709–720 (2011)
  Article CAS Google Scholar
• Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T. & Ohsumi, Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15, 1101–1111 (2004)
  Article CAS Google Scholar
• Mizushima, N., Yoshimori, T. & Levine, B. Methods in mammalian autophagy research. Cell 140, 313–326 (2010)
  Article CAS Google Scholar
• Shvets, E., Fass, E. & Elazar, Z. Utilizing flow cytometry to monitor autophagy in living mammalian cells. Autophagy 4, 621–628 (2008)
  Article CAS Google Scholar
• Radoshevich, L. et al. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell 142, 590–600 (2010)
  Article CAS Google Scholar
• Mohrin, M. et al. Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis. Cell Stem Cell 7, 174–185 (2010)
  Article CAS Google Scholar
• Lindsten, T. et al. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6, 1389–1399 (2000)
  Article CAS Google Scholar
• Mammucari, C. et al. FoxO3 controls autophagy in skeletal muscle in vivo . Cell Metab. 6, 458–471 (2007)
  Article CAS Google Scholar
• Maiuri, M. C. et al. Autophagy regulation by p53. Curr. Opin. Cell Biol. 22, 181–185 (2010)
  Article CAS Google Scholar
• Tothova, Z. et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128, 325–339 (2007)
  Article CAS Google Scholar
• Rubinsztein, D. C., Marino, G. & Kroemer, G. Autophagy and aging. Cell 146, 682–695 (2011)
  Article CAS Google Scholar
• Chen, C., Liu, Y. & Zheng, P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal. 2, ra75 (2009)
  PubMed PubMed Central Google Scholar
• Ergen, A. V., Boles, N. C. & Goodell, M. A. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood 119, 2500–2509 (2012)
  Article CAS Google Scholar
• Lum, J. J. et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237–248 (2005)
  Article CAS Google Scholar
• Wilson, A., Laurenti, E. & Trumpp, A. Balancing dormant and self-renewing hematopoietic stem cells. Curr. Opin. Genet. Dev. 19, 461–468 (2009)
  Article CAS Google Scholar
• Miyamoto, K. et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 1, 101–112 (2007)
  Article CAS Google Scholar
• Castrillon, D. H., Miao, L., Kollipara, R., Horner, J. W. & DePinho, R. A. Suppression of ovarian follicle activation in mice by the transcription factor FoxO3a. Science 301, 215–218 (2003)
  Article ADS CAS Google Scholar
• Donehower, L. A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215–221 (1992)
  Article ADS CAS Google Scholar
• Takeuchi, O. et al. Essential role of BAX, BAK in B cell homeostasis and prevention of autoimmune disease. Proc. Natl Acad. Sci. USA 102, 11272–11277 (2005)
  Article ADS CAS Google Scholar
• Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427–1429 (1995)
  Article ADS CAS Google Scholar
• Santaguida, M. et al. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell 15, 341–352 (2009)
  Article CAS Google Scholar
• Lock, R. et al. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol. Biol. Cell 22, 165–178 (2011)
  Article CAS Google Scholar