Mitonuclear protein imbalance as a conserved longevity mechanism (original) (raw)

• Fontana, L., Partridge, L. & Longo, V. D. Extending healthy life span–from yeast to humans. Science 328, 321–326 (2010)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Houtkooper, R. H., Williams, R. W. & Auwerx, J. Metabolic networks of longevity. Cell 142, 9–14 (2010)
  Article CAS PubMed Google Scholar
• Kenyon, C. J. The genetics of ageing. Nature 464, 504–512 (2010)
  Article ADS CAS PubMed Google Scholar
• Mair, W. & Dillin, A. Aging and survival: the genetics of life span extension by dietary restriction. Annu. Rev. Biochem. 77, 727–754 (2008)
  Article CAS PubMed Google Scholar
• Pagliarini, D. J. et al. A mitochondrial protein compendium elucidates complex I disease biology. Cell 134, 112–123 (2008)
  Article CAS PubMed PubMed Central Google Scholar
• Sharma, M. R. et al. Structure of the mammalian mitochondrial ribosome reveals an expanded functional role for its component proteins. Cell 115, 97–108 (2003)
  Article CAS PubMed Google Scholar
• Anderson, S. et al. Sequence and organization of the human mitochondrial genome. Nature 290, 457–465 (1981)
  Article ADS CAS PubMed Google Scholar
• Liao, C. Y., Rikke, B. A., Johnson, T. E., Diaz, V. & Nelson, J. F. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell 9, 92–95 (2010)
  Article CAS PubMed Google Scholar
• Argmann, C. A., Chambon, P. & Auwerx, J. Mouse phenogenomics: the fast track to “systems metabolism”. Cell Metab. 2, 349–360 (2005)
  Article CAS PubMed Google Scholar
• Andreux, P. A. et al. Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits. Cell 150, 1287–1299 (2012)
  Article CAS PubMed PubMed Central Google Scholar
• Peirce, J. L., Lu, L., Gu, J., Silver, L. M. & Williams, R. W. A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genet. 5, 7 (2004)
  Article PubMed PubMed Central Google Scholar
• Keane, T. M. et al. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477, 289–294 (2011)
  Article ADS CAS PubMed PubMed Central Google Scholar
• De Haan, G. & Van Zant, G. Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span. FASEB J. 13, 707–713 (1999)
  Article CAS PubMed Google Scholar
• Shifman, S. et al. A high-resolution single nucleotide polymorphism genetic map of the mouse genome. PLoS Biol. 4, e395 (2006)
  Article PubMed PubMed Central CAS Google Scholar
• Edwards, M. G. et al. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. BMC Genomics 8, 80 (2007)
  Article PubMed PubMed Central CAS Google Scholar
• Geisert, E. E. et al. Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. Mol. Vis. 15, 1730–1763 (2009)
  CAS PubMed PubMed Central Google Scholar
• Chen, Y. et al. Variations in DNA elucidate molecular networks that cause disease. Nature 452, 429–435 (2008)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Lee, S. S. et al. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nature Genet. 33, 40–48 (2003)
  Article CAS PubMed Google Scholar
• Hamilton, B. et al. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 19, 1544–1555 (2005)
  Article CAS PubMed PubMed Central Google Scholar
• Hansen, M., Hsu, A. L., Dillin, A. & Kenyon, C. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1, e17 (2005)
  Article PubMed Central CAS Google Scholar
• Wong, A., Boutis, P. & Hekimi, S. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics 139, 1247–1259 (1995)
  Article CAS PubMed PubMed Central Google Scholar
• Dillin, A. et al. Rates of behavior and aging specified by mitochondrial function during development. Science 298, 2398–2401 (2002)
  Article ADS CAS PubMed Google Scholar
• Kenyon, C., Chang, J., Gensch, E., Rudner, A. & Tabtiang, R. A. C. elegans mutant that lives twice as long as wild type. Nature 366, 461–464 (1993)
  Article ADS CAS PubMed Google Scholar
• Lakowski, B. & Hekimi, S. The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 95, 13091–13096 (1998)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Durieux, J., Wolff, S. & Dillin, A. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144, 79–91 (2011)
  Article CAS PubMed PubMed Central Google Scholar
• Haynes, C. M. & Ron, D. The mitochondrial UPR - protecting organelle protein homeostasis. J. Cell Sci. 123, 3849–3855 (2010)
  Article CAS PubMed Google Scholar
• Zhao, Q. et al. A mitochondrial specific stress response in mammalian cells. EMBO J. 21, 4411–4419 (2002)
  Article CAS PubMed PubMed Central Google Scholar
• Yoneda, T. et al. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J. Cell Sci. 117, 4055–4066 (2004)
  Article CAS PubMed Google Scholar
• Haynes, C. M., Yang, Y., Blais, S. P., Neubert, T. A. & Ron, D. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans.. Mol. Cell 37, 529–540 (2010)
  Article CAS PubMed PubMed Central Google Scholar
• Benedetti, C., Haynes, C. M., Yang, Y., Harding, H. P. & Ron, D. Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics 174, 229–239 (2006)
  Article CAS PubMed PubMed Central Google Scholar
• Overall, R. W. et al. Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front. Neurosci. 3, 55 (2009)
  PubMed PubMed Central Google Scholar
• Zylbee, E., Vesco, C. & Penman, S. Selective inhibition of the synthesis of mitochondria-associated RNA by ethidium bromide. J. Mol. Biol. 44, 195–204 (1969)
  Article Google Scholar
• Harrison, D. E. et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392–395 (2009)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Robida-Stubbs, S. et al. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15, 713–724 (2012)
  Article CAS PubMed PubMed Central Google Scholar
• Zid, B. M. et al. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 139, 149–160 (2009)
  Article CAS PubMed PubMed Central Google Scholar
• Schulz, T. J. et al. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 6, 280–293 (2007)
  Article CAS PubMed Google Scholar
• Zarse, K. et al. Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab. 15, 451–465 (2012)
  Article CAS PubMed PubMed Central Google Scholar
• Schägger, H. & Pfeiffer, K. Supercomplexes in the respiratory chains of yeast and mammalian mitochondria. EMBO J. 19, 1777–1783 (2000)
  Article PubMed PubMed Central Google Scholar
• De Haan, G. & Van Zant, G. Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span. FASEB J. 13, 707–713 (1999)
  Article CAS PubMed Google Scholar
• Geisert, E. E. et al. Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. Mol. Vis. 15, 1730–1763 (2009)
  CAS PubMed PubMed Central Google Scholar
• Chen, Y. et al. Variations in DNA elucidate molecular networks that cause disease. Nature 452, 429–435 (2008)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Reich, M. et al. GenePattern 2.0. Nature Genet. 38, 500–501 (2006)
  Article CAS PubMed Google Scholar
• de Hoon, M. J., Imoto, S., Nolan, J. & Miyano, S. Open source clustering software. Bioinformatics 20, 1453–1454 (2004)
  Article CAS PubMed Google Scholar
• Kamath, R. S., Martinez-Campos, M., Zipperlen, P., Fraser, A. G. & Ahringer, J. Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol. 2, research0002––research0002.10 (2000)
  Article PubMed PubMed Central Google Scholar
• Mouchiroud, L. et al. Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. Aging Cell 10, 39–54 (2011)
  Article CAS PubMed Google Scholar
• Wood, J. G. et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686–689 (2004)
  Article ADS CAS PubMed Google Scholar
• Durieux, J., Wolff, S. & Dillin, A. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144, 79–91 (2011)
  Article CAS PubMed PubMed Central Google Scholar
• Yang, W. & Hekimi, S. A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol. 8, e1000556 (2010)
  Article PubMed PubMed Central CAS Google Scholar
• Watanabe, M. et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439, 484–489 (2006)
  Article ADS CAS PubMed Google Scholar
• Lagouge, M. et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 127, 1109–1122 (2006)
  Article CAS PubMed Google Scholar
• Ryu, D. et al. Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistance. Diabetes 60, 1072–1081 (2011)
  Article CAS PubMed PubMed Central Google Scholar
• Noriega, L. G. et al. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. EMBO Rep. 12, 1069–1076 (2011)
  Article CAS PubMed PubMed Central Google Scholar