- Kim, M.Y. et al. Tumor self-seeding by circulating cancer cells. Cell 139, 1315–1326 (2009).
Article Google Scholar
- Nguyen, D.X., Bos, P.D. & Massague, J. Metastasis: from dissemination to organ-specific colonization. Nat. Rev. Cancer 9, 274–284 (2009).
Article CAS Google Scholar
- Pantel, K., Alix-Panabieres, C. & Riethdorf, S. Cancer micrometastases. Nat. Rev. Clin. Oncol. 6, 339–351 (2009).
Article CAS Google Scholar
- Jemal, A. et al. Global cancer statistics. CA Cancer J. Clin. 61, 69–90 (2011).
Article Google Scholar
- Yu, M., Stott, S., Toner, M., Maheswaran, S. & Haber, D.A. Circulating tumor cells: approaches to isolation and characterization. J. Cell Biol. 192, 373–382 (2011).
Article CAS Google Scholar
- Krebs, M.G. et al. Evaluation and prognostic significance of circulating tumor cells in patients with non-small-cell lung cancer. J. Clin. Oncol. 29, 1556–1563 (2011).
Article Google Scholar
- Cohen, S.J. et al. Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer. Ann. Oncol. 20, 1223–1229 (2009).
Article CAS Google Scholar
- de Bono, J.S. et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin. Cancer Res. 14, 6302–6309 (2008).
Article CAS Google Scholar
- Cristofanilli, M. et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N. Engl. J. Med. 351, 781–791 (2004).
Article CAS Google Scholar
- Budd, G.T. et al. Circulating tumor cells versus imaging–predicting overall survival in metastatic breast cancer. Clin. Cancer Res. 12, 6403–6409 (2006).
Article CAS Google Scholar
- Kling, J. Beyond counting tumor cells. Nat. Biotechnol. 30, 578–580 (2012).
Article CAS Google Scholar
- Kalluri, R. & Weinberg, R.A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 119, 1420–1428 (2009).
Article CAS Google Scholar
- Rhim, A.D. et al. EMT and dissemination precede pancreatic tumor formation. Cell 148, 349–361 (2012).
Article CAS Google Scholar
- Yu, M. et al. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science 339, 580–584 (2013).
Article CAS Google Scholar
- Braun, S. et al. A pooled analysis of bone marrow micrometastasis in breast cancer. N. Engl. J. Med. 353, 793–802 (2005).
Article CAS Google Scholar
- Shiozawa, Y. et al. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J. Clin. Invest. 121, 1298–1312 (2011).
Article CAS Google Scholar
- Riethdorf, S. et al. Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system. Clin. Cancer Res. 13, 920–928 (2007).
Article CAS Google Scholar
- Ito, M. et al. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100, 3175–3182 (2002).
Article CAS Google Scholar
- Mazurier, F., Doedens, M., Gan, O.I. & Dick, J.E. Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nat. Med. 9, 959–963 (2003).
Article CAS Google Scholar
- Lapidot T., Dar A. & Kollet, O. How do stem cells find their way home? Blood 106, 1901–1910 (2005).
- Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J. & Clarke, M.F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA 100, 3983–3988 (2003).
Article CAS Google Scholar
- Liu, H. et al. Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc. Natl. Acad. Sci. USA 107, 18115–18120 (2010).
Article CAS Google Scholar
- Willingham, S.B. et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc. Natl. Acad. Sci. USA 109, 6662–6667 (2012).
Article CAS Google Scholar
- Majeti, R. et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 138, 286–299 (2009).
Article CAS Google Scholar
- Chao, M.P. et al. Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. Cancer Res. 71, 1374–1384 (2011).
Article CAS Google Scholar
- Chan, K.S. et al. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc. Natl. Acad. Sci. USA 106, 14016–14021 (2009).
Article CAS Google Scholar
- Chao, M.P. et al. Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell 142, 699–713 (2010).
Article CAS Google Scholar
- Edris, B. et al. Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Proc. Natl. Acad. Sci. USA 109, 6656–6661 (2012).
Article CAS Google Scholar
- Nagahara, M. et al. Correlated expression of CD47 and SIRPA in bone marrow and in peripheral blood predicts recurrence in breast cancer patients. Clin. Cancer Res. 16, 4625–4635 (2010).
Article CAS Google Scholar
- Trusolino, L., Bertotti, A. & Comoglio, P.M. MET signalling: principles and functions in development, organ regeneration and cancer. Nat. Rev. Mol. Cell Biol. 11, 834–848 (2010).
Article CAS Google Scholar
- Orian-Rousseau, V. CD44, a therapeutic target for metastasising tumours. Eur. J. Cancer 46, 1271–1277 (2010).
Article CAS Google Scholar
- Shibue, T. & Weinberg, R.A. Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Semin. Cancer Biol. 21, 99–106 (2011).
Article CAS Google Scholar
- Kasimir-Bauer, S., Hoffmann, O., Wallwiener, D., Kimmig, R. & Fehm, T. Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells. Breast Cancer Res. 14, R15 (2012).
Article CAS Google Scholar
- Powell, A.A. et al. Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines. PLoS ONE 7, e33788 (2012).
Article CAS Google Scholar
- Nagrath, S. et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450, 1235–1239 (2007).
Article CAS Google Scholar
- Stott, S.L. et al. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc. Natl. Acad. Sci. USA 107, 18392–18397 (2010).
Article CAS Google Scholar
- Chao, M.P., Majeti, R. & Weissman, I.L. Programmed cell removal: a new obstacle in the road to developing cancer. Nat. Rev. Cancer 12, 58–67 (2012).
Article CAS Google Scholar
- Orian-Rousseau, V., Chen, L., Sleeman, J.P., Herrlich, P. & Ponta, H. CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev. 16, 3074–3086 (2002).
Article CAS Google Scholar
- Baccelli, I. & Trumpp, A. The evolving concept of cancer and metastasis stem cells. J. Cell Biol. 198, 281–293 (2012).
Article CAS Google Scholar
- Bao, S. et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756–760 (2006).
Article CAS Google Scholar
- Chao, M.P., Weissman, I.L. & Majeti, R. The CD47-SIRPalpha pathway in cancer immune evasion and potential therapeutic implications. Curr. Opin. Immunol. 24, 225–232 (2012).
Article CAS Google Scholar
- Gherardi, E., Birchmeier, W., Birchmeier, C. & Woude, G.V. Targeting MET in cancer: rationale and progress. Nat. Rev. Cancer 12, 89–103 (2012).
Article CAS Google Scholar
- Riethdorf, S. et al. Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial. Clin. Cancer Res. 16, 2634–2645 (2010).
Article CAS Google Scholar