TALEN-mediated editing of the mouse Y chromosome (original) (raw)

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Acknowledgements

We thank K. Ganz and R. Flannery for support with animal care and experiments. We thank Jaenisch and Page laboratory members for helpful discussions on the manuscript. A.W.C. is supported by a Croucher scholarship. D.C.P. and Y.-C.H. were supported by Howard Hughes Medical Institute. R.J., H.W., S.M., G.G.W., C.S.S. and A.W.C. were supported by US National Institutes of Health grants R37-HD045022 and R01-CA084198. T.P. was supported by US National Institutes of Health grant R01-HG000257.

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Author notes

  1. Haoyi Wang and Yueh-Chiang Hu: These authors contributed equally to this work.

Authors and Affiliations

  1. Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Haoyi Wang, Yueh-Chiang Hu, Styliani Markoulaki, G Grant Welstead, Albert W Cheng, Chikdu S Shivalila, Tatyana Pyntikova, Daniel B Dadon, David C Page & Rudolf Jaenisch
  2. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Yueh-Chiang Hu & David C Page
  3. Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Albert W Cheng
  4. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Chikdu S Shivalila, Daniel B Dadon, David C Page & Rudolf Jaenisch
  5. Department of Genetics, Cell Biology and Development, University of Minnesota, St. Paul, Minnesota, USA
    Daniel F Voytas
  6. Department of Plant Pathology and Plant-Microbe Biology, Cornell University, Ithaca, New York, USA
    Adam J Bogdanove

Authors

  1. Haoyi Wang
  2. Yueh-Chiang Hu
  3. Styliani Markoulaki
  4. G Grant Welstead
  5. Albert W Cheng
  6. Chikdu S Shivalila
  7. Tatyana Pyntikova
  8. Daniel B Dadon
  9. Daniel F Voytas
  10. Adam J Bogdanove
  11. David C Page
  12. Rudolf Jaenisch

Contributions

H.W., Y.-C.H., D.C.P. and R.J. designed the experiments and wrote the manuscript. H.W., D.F.V. and A.J.B. designed TALENs. H.W. generated and tested TALENs. H.W. performed targeting experiments. C.S.S. and D.B.D. assisted with Southern blot analysis. S.M. performed tetraploid complementation experiments. Y.-C.H. and G.G.W. maintained mutant mouse colonies and performed animal-related experiments. T.P. performed FISH analysis. A.W.C. performed the off-target analysis. H.W., Y.-C.H. and G.G.W. analyzed the data.

Corresponding authors

Correspondence toDavid C Page or Rudolf Jaenisch.

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Competing interests

The authors declare no competing financial interests.

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Wang, H., Hu, YC., Markoulaki, S. et al. TALEN-mediated editing of the mouse Y chromosome.Nat Biotechnol 31, 530–532 (2013). https://doi.org/10.1038/nbt.2595

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