Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity (original) (raw)

• Steinman, R.M., Hawiger, D. & Nussenzweig, M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21, 685–711 (2003).
  Article CAS Google Scholar
• Pardoll, D. Does the immune system see tumors as foreign or self? Annu. Rev. Immunol. 21, 807–839 (2003).
  Article CAS Google Scholar
• Alegre, M.L., Frauwirth, K.A. & Thompson, C.B. T-cell regulation by CD28 and CTLA-4. Nat. Rev. Immunol. 1, 220–228 (2001).
  Article CAS Google Scholar
• Timmerman, J.M. & Levy, R. Dendritic cell vaccines for cancer immunotherapy. Annu. Rev. Med. 50, 507–529 (1999).
  Article CAS Google Scholar
• Chen, L. Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity. Nat. Rev. Immunol. 4, 336–347 (2004).
  Article CAS Google Scholar
• Leach, D.R., Krummel, M.F. & Allison, J.P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271, 1734–1736 (1996).
  Article CAS Google Scholar
• Hodi, F.S. et al. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc. Natl. Acad. Sci. USA 100, 4712–4717 (2003).
  Article CAS Google Scholar
• Phan, G.Q. et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc. Natl. Acad. Sci. USA 100, 8372–8377 (2003).
  Article CAS Google Scholar
• Kubo, M., Hanada, T. & Yoshimura, A. Suppressors of cytokine signaling and immunity. Nat. Immunol. 4, 1169–1176 (2003).
  Article CAS Google Scholar
• Alexander, W.S. & Hilton, D.J. The Role of Suppressors of Cytokine Signaling (SOCS) Proteins in Regulation of the Immune Response. Annu. Rev. Immunol. 22, 503–529 (2004).
  Article CAS Google Scholar
• Marine, J.C. et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98, 609–616 (1999).
  Article CAS Google Scholar
• Alexander, W.S. et al. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98, 597–608 (1999).
  Article CAS Google Scholar
• Naka, T. et al. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity 14, 535–545 (2001).
  Article CAS Google Scholar
• Metcalf, D., Mifsud, S., Di Rago, L. & Alexander, W.S. The lethal effects of transplantation of Socs1−/− bone marrow cells into irradiated adult syngeneic recipients. Proc. Natl. Acad. Sci. USA 100, 8436–8441 (2003).
  Article CAS Google Scholar
• Hanada, T. et al. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19, 437–450 (2003).
  Article CAS Google Scholar
• Kinjyo, I. et al. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17, 583–591 (2002).
  Article CAS Google Scholar
• Hill, J.A. et al. Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA. J. Immunol. 171, 691–696 (2003).
  Article CAS Google Scholar
• Livak, K.J. & Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402–408 (2001).
  Article CAS Google Scholar
• Chong, M.M. et al. Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity 18, 475–487 (2003).
  Article CAS Google Scholar
• Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H. & Williams, B.R. Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol. 5, 834–839 (2003).
  Article CAS Google Scholar
• Rubinson, D.A. et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat. Genet. 33, 401–406 (2003).
  Article CAS Google Scholar
• Schroers, R. & Chen, S.Y. Lentiviral transduction of human dendritic cells. Methods Mol. Biol. 246, 451–459 (2004).
  CAS PubMed Google Scholar
• Srivastava, P. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu. Rev. Immunol. 20, 395–425 (2002).
  Article CAS Google Scholar
• van Elsas, A. et al. Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J. Exp. Med. 194, 481–489 (2001).
  Article CAS Google Scholar
• Porgador, A. et al. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J. Exp. Med. 188, 1075–1082 (1998).
  Article CAS Google Scholar
• Garg, S. et al. Genetic tagging shows increased frequency and longevity of antigen-presenting, skin-derived dendritic cells in vivo. Nat. Immunol. 4, 907–912 (2003).
  Article CAS Google Scholar
• Menges, M. et al. Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity. J. Exp. Med. 195, 15–21 (2002).
  Article CAS Google Scholar
• Pasare, C. & Medzhitov, R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299, 1033–1036 (2003).
  Article CAS Google Scholar
• Yang, Y., Huang, C.T., Huang, X. & Pardoll, D.M. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat. Immunol. 5, 508–515 (2004).
  Article CAS Google Scholar
• You, Z. et al. Induction of vigorous helper and cytotoxic T cell as well as B cell responses by DCs expressing a modified antigen targeting receptor-mediated internalization pathway. J. Immunol. 165, 4581–4592 (2000).
  Article CAS Google Scholar
• Huang, X.F. et al. A broadly applicable, personalized heat shock protein-mediated oncolytic tumor vaccine. Cancer Res. 63, 7321–7329 (2003).
  CAS PubMed Google Scholar
• Chen, J., Yang, A., Bai, X., Cong, Y. & Chen, S-Y. Inactivation of HIV-1 chemokine co-receptor CXCR4 by a novel intraline approach. Nat. Med. 3, 1110–1116 (1997).
  Article CAS Google Scholar
• Brummelkamp, T.R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550–553 (2002).
  Article CAS Google Scholar